Metabolites News and Research

RSS

Whole wheat diets may reduce the risk of inflammatory bowel disease

Enriching the diet with wheat fiber protects mice against intestinal inflammation, according to a study published by researchers in the Institute for Biomedical Sciences (IBMS) at Georgia State University.

25 Mar 2026

New approach helps immune cells find and attack solid tumors

A technique that transforms immune cells into cancer-seeking bloodhounds may overcome a roadblock that has hampered immunotherapy for solid tumors, according to a new study by Stanford Medicine researchers.

24 Mar 2026

Wholegrain rye changes gut bacteria and lowers inflammation in obesity trial

In a 12-week randomized trial, replacing refined wheat with wholegrain rye in a calorie-restricted diet did not produce greater weight loss in adults with overweight or obesity. Wholegrain rye did, however, lower C-reactive protein and alter gut microbiota and short-chain fatty acids in ways that may have positive cardiometabolic implications.

24 Mar 2026

Python blood compound could lead to new weight loss therapies

University of Colorado Boulder researchers have discovered an appetite-suppressing compound in python blood that helps the snakes consume enormous meals and go months without eating yet remain metabolically healthy.

19 Mar 2026

Cancer cells rely on glutathione as fuel for growth

Researchers discovered an antioxidant, glutathione, that cancer cells appear to be "addicted to" as fuel, opening new pathways for investigation and a potential drug that can restrict the way tumors use this nutrient.

18 Mar 2026

Gut-derived blood markers may help predict who develops coronary heart disease

Researchers used five prospective cohorts from the US and China to identify circulating gut microbiota-related metabolites linked to future coronary heart disease, then tested the findings through discovery, in silico validation, and targeted quantitative validation. The study ultimately highlighted nine metabolites associated with incident CHD, supporting a potential role for microbial metabolism in heart disease risk while not proving causation

18 Mar 2026

Gut microbe molecules linked to coronary heart disease risk

In a study involving data from thousands of people, the risk of a new coronary heart disease diagnosis was statistically associated with bloodstream levels of nine specific molecules that are produced by gut microbes.

17 Mar 2026

Yogurt, cheese, and chocolate consumption is tied to reduced mortality risk, researchers report

A large meta-analysis of 50 cohort studies involving over three million adults found that higher consumption of certain fermented foods is associated with lower risks of all-cause and cardiovascular mortality. Fermented milk products also showed inverse associations with cancer mortality, while other foods like miso and bread showed no consistent effects.

17 Mar 2026

Boosting noradrenaline during learning makes the brain link memories more broadly, study finds

A randomized placebo controlled experiment shows that increasing noradrenaline during learning does not improve basic memory accuracy but increases the spread of associations across the hippocampal cognitive map. This broader neural linking leads to greater overgeneralization errors days later, suggesting that noradrenergic arousal can reshape how related memories become interconnected.

16 Mar 2026

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the 2026 release of Mass Spectra of Designer Drugs, the essential GC‑MS spectral database used by forensic laboratories worldwide for the rapid identification of illicit substances.

From John Wiley and Sons - Scientific Publishers 16 Mar 2026

Why do some people respond better to GLP-1 drugs? Gut microbiome may hold clues

A review in the Canadian Journal of Physiology and Pharmacology examines emerging evidence linking glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the gut microbiome, and obesity treatment outcomes. The authors conclude that microbiome changes seen during therapy are most likely driven by diet, behavior, and weight loss, although microbial profiling may eventually help predict patient responses.

15 Mar 2026

Scientists show gut bacteria can reach the brain in mice and reveal a potential vagus nerve pathway

Researchers found that very small numbers of gut bacteria can translocate to the brain in mice, particularly when gut barrier permeability increases due to a Paigen diet. Evidence suggests the vagus nerve may serve as a partial route for this gut-to-brain microbial movement.

15 Mar 2026

Gene mutation that aids high-altitude survival could repair myelin sheath damage

A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing nerve damage in conditions such as cerebral paralysis and multiple sclerosis (MS).

13 Mar 2026

Swapping red meat for plant-based meat rapidly lowers a key heart risk metabolite, trial finds

A randomized crossover trial found that replacing red meat patties with processed plant-based meat alternatives for six days significantly lowered circulating trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardiovascular risk. The plant-based phase also produced modest reductions in cholesterol markers but slightly increased weight and NT-proBNP, possibly due to higher sodium intake.

12 Mar 2026

Gut microbes may drive memory decline during aging by disrupting vagal brain signaling

Researchers identified in mice a microbiome–gut–brain pathway in which age-associated changes in gut microbes increase medium-chain fatty acids that impair vagal sensory signaling and hippocampal activity. These interoceptive disruptions weaken memory formation, revealing a microbial mechanism that contributes to cognitive decline during aging.

12 Mar 2026

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Researchers analyzed gut microbiome profiles from 4,792 adults in the HELIUS cohort and tracked cardiometabolic outcomes over time to determine whether specific microbes predict disease risk. Certain microbes were linked to higher or lower cardiovascular risk, while plant-derived microbial metabolites suggested potential diet–microbiome interactions influencing heart health.

9 Mar 2026

Microbial ecosystems influence success of cancer checkpoint immunotherapy

Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.

9 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026

Copper metabolism identified as a new therapeutic target for inflammatory osteolysis

Inflammatory osteolysis is a condition involving progressive bone tissue destruction and is observed in many well-known skeletal disorders, including rheumatoid arthritis, osteoporosis, and chronic apical periodontitis.

5 Mar 2026

No evidence probiotic skincare can improve mood

Current findings reveal no support for emotional benefits from probiotic cosmetics, highlighting the need for further investigation into neurocosmetics.

5 Mar 2026

Metabolites News and Research

Whole wheat diets may reduce the risk of inflammatory bowel disease

New approach helps immune cells find and attack solid tumors

Wholegrain rye changes gut bacteria and lowers inflammation in obesity trial

Python blood compound could lead to new weight loss therapies

Cancer cells rely on glutathione as fuel for growth

Gut-derived blood markers may help predict who develops coronary heart disease

Gut microbe molecules linked to coronary heart disease risk

Yogurt, cheese, and chocolate consumption is tied to reduced mortality risk, researchers report

Boosting noradrenaline during learning makes the brain link memories more broadly, study finds

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

Why do some people respond better to GLP-1 drugs? Gut microbiome may hold clues

Scientists show gut bacteria can reach the brain in mice and reveal a potential vagus nerve pathway

Gene mutation that aids high-altitude survival could repair myelin sheath damage

Swapping red meat for plant-based meat rapidly lowers a key heart risk metabolite, trial finds

Gut microbes may drive memory decline during aging by disrupting vagal brain signaling

Specific gut bacteria may signal long-term risk of heart and metabolic disease

Microbial ecosystems influence success of cancer checkpoint immunotherapy

Researchers propose that Parkinson’s disease may start in the gut, not the brain

Copper metabolism identified as a new therapeutic target for inflammatory osteolysis

No evidence probiotic skincare can improve mood

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News