Small Molecules News and Research

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Breakthrough discovery offers hope for treating neurodegenerative diseases

Researchers have discovered how to block cells dying, in a finding that could lead to new treatments for neurodegenerative conditions like Parkinson's and Alzheimer's.

12 May 2025

New AI approach speeds up antiviral discovery for human enterovirus 71

Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.

6 May 2025

Machine learning uncovers promising drug leads against human enterovirus 71

Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.

29 Apr 2025

AI helps uncover hidden role of gene in Alzheimer’s disease

A new study found that a gene recently recognized as a biomarker for Alzheimer's disease is actually a cause of it, due to its previously unknown secondary function.

25 Apr 2025

New era of medicine emerges through structural control of nanotherapeutics

Historically, the vast majority of pharmaceutical drugs have been meticulously designed down to the atomic level.

25 Apr 2025

New expansion technique brings mass spectrometry imaging to single cell level

For biologists, seeing is believing. But sometimes biologists have a hard time seeing.

22 Apr 2025

New approach to treating chronic pain without opioids

Chronic pain, a common and debilitating condition, often leads practitioners to prescribe opioids in escalating doses.

22 Apr 2025

Breakthrough molecule offers hope for treating rare mitochondrial diseases

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production.

9 Apr 2025

Scientists stop long-COVID symptoms in mice using a new antiviral compound

Australian scientists developed a novel antiviral that targets the SARS-CoV-2 PLpro enzyme, showing strong preclinical efficacy in reducing both acute and long COVID symptoms in mice.

9 Apr 2025

Dynamic BH3 profiling offers personalized lung cancer therapies

Eighty-five percent of diagnosed cases of lung cancer are non-small cell lung cancer (NSCLC). In this group, 5% of patients show molecular alterations in the ALK gene involved in cell multiplication.

9 Apr 2025

New structural and mechanistic understanding for cancer drug design

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and mechanistic understanding of the RAD52-DNA complex may help researchers develop new anti-cancer drugs.

3 Apr 2025

Gut microbiome interventions could stop type 1 diabetes in its tracks

Researchers at The University of Queensland have found improving the function of the gut microbiome may delay the onset of type 1 diabetes (T1D).

2 Apr 2025

New drug strategy targets Staphylococcus aureus toxin to treat pneumonia

Pneumonia caused by the bacterium Staphylococcus aureus is one of the most dangerous infections that can occur in hospital.

2 Apr 2025

Traditional Chinese medicine targets cholesterol metabolism for cancer treatment

Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat cancer.

31 Mar 2025

Harnessing intestinal microbes to combat inflammation and infections

Despite being an everyday necessity, nutrition is something of a black box. We know that many plant-based foods are good for us, but we don't always know why.

27 Mar 2025

Duke-NUS and NUS Medicine launch first-ever joint center to drive metabolomics research

In a strategic move for medical research and innovation, Duke-NUS Medical School and the National University of Singapore Yong Loo Lin School of Medicine (NUS Medicine) have launched the Systems Metabolomics Centre (SysMeC), their first-ever joint research center.

22 Mar 2025