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Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

Study reveals harmful effects of conversion therapy on LGBTQ+ people

People identifying as LGBTQ+ who have undergone conversion practice – commonly known as conversion therapy – are more likely to experience poor mental health, according to a study published in The Lancet Psychiatry journal.

1 Oct 2024

Advanced brain mapping reveals neuronal subtypes and their connections

Scientists at the Salk Institute are unveiling a new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START). The cutting-edge tool combines two advanced technologies - monosynaptic rabies virus tracing and single-cell transcriptomics - to map the brain's intricate neuronal connections with unparalleled precision.

30 Sep 2024

AI-powered blood test promises early detection of ovarian cancer

A blood test that uses artificial intelligence (AI) to detect cancer-related genetic changes and protein biomarkers could help screen women for early signs of ovarian cancer, according to a study by researchers at the Johns Hopkins Kimmel Cancer Center in collaboration with several other institutions in the United States and Europe.

30 Sep 2024

How viral persistence and immune dysfunction drive long COVID

Study explores the biological drivers and mechanisms of long COVID, shedding light on its epidemiology and potential therapeutic interventions. It emphasizes the role of viral persistence, immune dysfunction, and coagulation in the development of this condition.

29 Sep 2024

NIH awards grant to study how dilated cardiomyopathy progresses to heart failure

A University of Arizona College of Medicine – Phoenix researcher was recently awarded a $1.9 million National Institutes of Health grant to study the molecular mechanisms of how dilated cardiomyopathy progresses to heart failure, which could eventually lead to better preventive and treatment options for heart failure.

27 Sep 2024

Advances in mitochondria-targeted medicine for TBI in military settings

During the 15th Annual Meeting of the World Mitochondria Society (WMS), taking place in Berlin, Germany, groundbreaking research on mitochondria-targeted medicine in military settings will be highlighted.

27 Sep 2024

Scientists unravel the process of pore formation in cells

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers.

26 Sep 2024

Cleveland Clinic identifies bacterium that weakens gut immune defense

Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.

26 Sep 2024

Barcoding technology reveals secrets of cancer metastasis

Metastatic cancer can be a devastating diagnosis. The cancer is spreading. It may travel to multiple organs in the body. This could mean more pain and ultimately, death.

26 Sep 2024

Centenarians' stem cells unlock secrets to healthy aging

Individuals who display exceptional longevity provide evidence that humans can live longer, healthier lives.

25 Sep 2024

Researchers identify drug with anti-aging effects

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body.

25 Sep 2024

CRISPR-Cas13 emerges as a game changer in RNA-targeted therapies

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

25 Sep 2024

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal cord.

24 Sep 2024

Neurostimulation target identified for treating PTSD in veterans

A new study led by researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder (PTSD) in veterans.

24 Sep 2024

Space conditions disrupt rhythmic function of bioengineered heart tissues

Johns Hopkins Medicine scientists who arranged for 48 human bioengineered heart tissue samples to spend 30 days at the International Space Station report evidence that the low gravity conditions in space weakened the tissues and disrupted their normal rhythmic beats when compared to earth-bound samples from the same source.

23 Sep 2024

Breakthrough research reveals key role of melatonin receptor in REM sleep

A significant breakthrough in the understanding of sleep mechanism opens new promise for treating sleep disorders and associated neuropsychiatric conditions: Scientists have pinpointed the melatonin receptor MT1 as a crucial regulator of REM (Rapid Eye Movement) sleep.

23 Sep 2024

Urgent call for long-term investment in antibiotic research

Antibiotic resistance is a global public health threat. Modern health systems rely on antibiotics to prevent and treat infections, and the need for new drugs is urgent.

23 Sep 2024

Study uncovers novel genetic variant associated with intellectual disability

Researchers at the Icahn School of Medicine at Mount Sinai have published a pivotal study in Nature Genetics (DOI: 10.1038/s41588-024-01917-1) that sheds light on a novel genetic variant associated with intellectual capacities and educational outcomes.

23 Sep 2024

Broken String Biosciences appoints Laurence Reid and Brad Crutchfield to its Board of Directors

Broken String Biosciences enhances its leadership team with Laurence Reid and Brad Crutchfield, aiming to revolutionize cell and gene therapy development.

From Broken String Biosciences 23 Sep 2024