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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Scale Biosciences announces ScalePlex technology to simplify single cell genomics studies of any scale

Novel multiplexing technology enables seamless sample pooling facilitating cost-efficient single cell experiments for compound screening and translational research.

26 Jun 2024

Study reveals novel therapeutic approach for excessive alcohol use

In a significant finding, researchers from The Jackson Laboratory (JAX) and UConn Health have discovered that sodium valerate, a short-chain fatty acid produced by gut microbes, can dramatically reduce binge drinking behavior and blood ethanol concentration in mice.

25 Jun 2024

Breakthrough biomarker predicts recurrence risk in clear cell renal cancer

Researchers from the University of Michigan Health Rogel Cancer Center have discovered a biomarker that could help identify which renal cancer patients have a higher risk of recurrence.

25 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

Research shows gut bacteria's role in mental resilience and reduced anxiety

Researchers characterized brain-gut microbiome (BGM) patterns related to stress resilience.

25 Jun 2024

Open-source platform enables high-definition spatial transcriptomics

An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

25 Jun 2024

Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Study reveals early immune responses to SARS-CoV-2, offering insights for future COVID-19 treatments

Researchers analyzed early immune responses to SARS-CoV-2 using single-cell multi-omics, revealing key cellular states associated with different infection outcomes.

24 Jun 2024

Antisense RNA acts as a cellular 'booster' for gene expression, study finds

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

24 Jun 2024

Dietary sucrose modulates lithium's regulatory activity in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster."

24 Jun 2024

Low-cost CRISPR-based paper strip test offers rapid influenza diagnosis

Fewer than one percent of people who get the flu every year get tested, in part because most tests require trained personnel and expensive equipment.

21 Jun 2024

Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

Our bone marrow - the fatty, jelly-like substance inside our bones - is an unseen powerhouse quietly producing 500 billion new blood cells every day.

21 Jun 2024

Integrated cellular map of heart cells unlocks cardiac fibrosis process

Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure.

21 Jun 2024

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Liver transplants associated with alcohol-related disease are growing at a rapid pace, shifting research to address pathologies behind the ailments in light of a limited supply of organ donors.

21 Jun 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024