Glycated hemoglobin News and Research

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A three-drug diabetes pill outperformed dual therapy

Clinical trial results indicate that a fixed-dose combination of dapagliflozin, glimepiride, and metformin offers superior glycemic control in diabetes therapy.

4 Nov 2026

A low-calorie diet and exercise helped 54% of younger adults achieve diabetes remission

In a randomized clinical trial involving 96 adults with early-onset type 2 diabetes and obesity, a 24-week program combining a low-energy diet with supervised exercise achieved diabetes remission in 54% of participants, compared with 4% receiving usual care. The intervention also reduced body fat, largely preserved muscle mass, and improved strength and body-mass-adjusted fitness, although the additional benefits attributable specifically to exercise remain uncertain.

3 Nov 2026

Can broccoli sprouts help with insulin resistance? New review offers clues

A review published in the British Journal of Nutrition examines how carotenoids and bioactive compounds in Brassicaceae microgreens may influence obesity, insulin resistance, and type 2 diabetes through metabolic and inflammatory pathways. Small human trials involving broccoli sprouts have reported improvements in selected metabolic markers, but larger, longer-term studies are needed to establish their clinical benefits.

29 Oct 2026

Fish, shellfish or seaweed? A Korean study found striking differences in chemical exposure

A national study of 4,279 Korean adults found that higher finfish consumption was associated with increased blood concentrations of PFAS, PCBs, and mercury, while shellfish showed narrower associations with three PFAS. Persistent chemical mixtures were also associated with modest increases in liver health biomarkers, and mediation analysis identified a positive PFAS-related pathway, although finfish intake was not significantly associated with GGT overall.

29 Oct 2026

CT scans linked vitamin D levels to fat within muscles after bariatric surgery

Researchers followed 113 adults for one year after bariatric surgery and found that those with higher postoperative vitamin D concentrations had less fat infiltration within certain muscles and lower visceral adiposity. They found no significant association between increases in vitamin D and changes in body composition after correction for multiple comparisons, while preoperative vitamin D levels did not independently predict postoperative body composition.

27 Oct 2026

A study of 802 teens raises questions about school breakfast and blood sugar

A study of 802 U.S. adolescents found that school breakfast participation at least once weekly was associated with a 30% higher prevalence of prediabetes-range glucose markers, while school lunch participation showed no significant association. Higher intakes of vitamins E and B6 and fruit consumption among adolescents with obesity were associated with lower prediabetes prevalence, but none of the reported associations remained statistically significant after correction for multiple comparisons.

22 Oct 2026

Scientists studied one million immune cells and found clues to future disease risk

Researchers developed a single-cell atlas of one million human neutrophils, identifying distinct immune cell populations and gene-expression patterns across tissues, infections, cancer, and other health conditions. Certain neutrophil signatures were associated with metabolic dysfunction, cancer outcomes, and mortality, while higher routine neutrophil counts, even within the normal range, were linked to an increased risk of chronic disease.

22 Oct 2026

Could a hormone from our bones reveal early signs of insulin resistance?

Research reveals a link between osteocalcin and insulin resistance in obese children, suggesting early metabolic changes before glucose tolerance impairment.

21 Oct 2026

Could eating whey protein before meals help reduce blood sugar spikes?

A narrative review of 57 randomized trials found that milk and dairy products have inconsistent effects on long-term blood sugar control in adults with type 2 diabetes or prediabetes. Whey protein consumed before meals more consistently reduced short-term blood sugar spikes, but further research is needed to establish whether these benefits persist over time.

19 Oct 2026

AI study of 101,000 patients links brown fat to heart and mental health

In a retrospective analysis of PET-CT records from 101,243 patients, researchers found that detectable brown fat was associated with lower prevalence of cardiometabolic and psychiatric conditions, while greater activity, particularly in the axillary region, was linked to more favourable metabolic outcomes. Medication screening identified losartan, which increased brown fat thermogenic activity in laboratory experiments and energy expenditure in mice, although its effects on human brown fat remain unproven.

15 Oct 2026

From turmeric to fenugreek, scientists examine nature’s potential role in diabetes care

A narrative review examined how curcumin, honey, culinary spices, and traditional remedies may influence oxidative stress, inflammation, mitochondrial function, and insulin signaling in diabetes. Although experimental research and some clinical trials suggest potential metabolic benefits, the authors emphasize that larger, well-controlled studies are needed to establish their effectiveness and safety alongside conventional treatments.

14 Oct 2026

Diet drinks showed no clear weight-loss edge over water after two years

In a two-year randomized trial combining assisted weight management with an unassisted follow-up year, completers maintained average weight losses of 4.8 kg with diet drinks and 3.7 kg with water. Researchers found no significant difference between groups, but fewer than half of the 493 participants completed follow-up.

11 Oct 2026

Does extra protein protect aging muscle during fasting?

A randomized trial found that alternate-day fasting reduced weight in older men, while added protein and leucine did not prevent lean mass loss.

7 Oct 2026

High-fiber diet beats metformin for blood sugar and weight in trial

High-fiber diet improves blood sugar and weight more than metformin in a small diabetes trial.

7 Oct 2026

Do you really need to fast before a blood test? It depends on the test

The impact of fasting on blood test results is analyte-specific, with most routine tests showing minimal differences, suggesting a need for flexible guidelines.

1 Oct 2026

Semaglutide cuts major heart events, but researchers still cannot fully explain why

In adults with overweight or obesity and established cardiovascular disease but no diabetes, semaglutide reduced major adverse cardiovascular events by 20%, while changes in measured cardiovascular risk factors could not fully explain the benefit with certainty. The findings suggest that additional, as-yet unidentified biological pathways may contribute to semaglutide’s cardiovascular protection.

27 Sep 2026

As GLP-1 drugs become more complex, their effects on the heart are getting harder to predict

A brief report reviews emerging GLP-1 receptor co-agonists that also target GIPR, GCGR, and other receptors, examining their metabolic benefits alongside known and predicted cardiac effects. The authors highlight substantial species differences, warning that mouse heart studies may fail to predict responses in human cardiac tissue and that many proposed cardiac effects still require direct testing.

24 Sep 2026

A chemical used in BPA-free products may have a connection to diabetes control

In adults with type 2 diabetes receiving oral glucose-lowering therapy, higher plasma BPS concentrations were associated with higher HbA1c after accounting for demographic factors, medication adherence, and diet, whereas BPA was not associated with HbA1c. The BPS association was modest and no longer statistically significant after further adjustment for BPA, BMI, and physical fitness, supporting the need for larger studies to determine whether reducing exposure could improve glycemic control.

23 Sep 2026

Stevia tastes sweet, but does your body react as if sugar is coming?

In a randomized, double-blind crossover study, researchers tested stevia alone and with glucose in adults with normal weight, overweight, or type 2 diabetes to assess acute effects on blood glucose, insulin, gut hormones, appetite, and subsequent food intake. Stevia produced no significant changes in the measured glycemic or hormonal responses compared with water and did not significantly modify responses to glucose, while appetite and subsequent energy intake were also generally unchanged.

8 Sep 2026

GLP-1 drugs have benefits beyond weight loss. Could microdoses preserve them?

A narrative review suggests GLP-1-based therapies deliver metabolic, cardiovascular, renal, and other systemic benefits, raising interest in whether lower fractional doses could improve tolerability and treatment continuity. However, direct evidence for GLP-1 microdosing remains extremely limited, and researchers say prospective studies are needed to determine whether lower doses preserve long-term benefits.

1 Sep 2026