Sanger sequencing News and Research

RSS

Complete medaka genome sequence reveals repetitive DNA with biological significance

Researchers sequenced the genomes of three medakas, or Japanese rice fish, which are a common model organism used for biological research, nearly 10 and 20 years ago.

3 Aug 2026

Wild bird surveillance reveals how H5Nx flu keeps returning to China

Long-term wild bird surveillance across China revealed shifting H5Nx avian influenza patterns, with H5N1, H5N8, and clade 2.3.4.4b viruses changing over time and across migratory flyways. Genomic analyses suggest recent H5Nx detections in China largely reflect repeated reintroductions through migratory birds rather than sustained local circulation.

26 Jul 2026

Japanese study links inherited genetic variants to multiple lung cancers

Lung cancer remains the leading cause of cancer-related deaths worldwide and is generally thought to arise from mutations acquired over a lifetime through environmental exposures.

30 Jun 2026

Revvity unveils its Signals BioDesign offering to advance biologic research workflows

Revvity, Inc. announced that its Revvity Signals Software business is launching Signals BioDesign™, a cloud-native molecular cloning solution that streamlines biologics research workflows.

From Revvity Signals Software Inc. 10 Apr 2026

FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

9 Mar 2026

Study explores how reversible RNA editing could transform future cardiovascular medicine

This mini-review synthesises evidence showing that adenosine-to-inosine RNA editing plays an important regulatory role in cardiovascular development, cellular homeostasis, and disease biology. It highlights emerging links between dysregulated RNA editing and cardiovascular conditions while outlining biomarker potential and reversible RNA-editing therapeutic strategies that remain under investigation.

15 Feb 2026

Study validates OVCAR3 as a model for high-grade serous ovarian cancer

A new research paper was published in Volume 12 of Oncoscience on October 14, 2025, titled "Bridging clinical insight and laboratory model in high-grade serous ovarian carcinoma (HGSOC) using DNA sequencing-based profiling of TP53."

23 Dec 2025

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA circulating in the blood.

9 Dec 2025

Wind-borne mosquitoes carry infectious pathogens for hundreds of miles

High-flying mosquitoes in West Africa are carriers of multiple pathogens, including West Nile virus, highlighting risks in vector-borne disease management.

4 Dec 2025

Innovative system accurately detects genetic mutations in the brain tumor within 25 minutes

A research team in Japan has developed an innovative system that can accurately detect genetic mutations in the brain tumor within just 25 minutes.

9 Oct 2025

Gene-edited mosquitoes slash malaria spread 93% using self-propagating shield

Scientists engineered a naturally occurring genetic variant (Q224) in Anopheles stephensi mosquitoes, making them highly resistant to malaria parasites without affecting fitness. A novel gene-drive system rapidly spread this protective trait through lab mosquito populations, offering a potential breakthrough for malaria control.

24 Jul 2025

Japanese bats found carrying high levels of novel viruses, raising concerns about zoonotic outbreaks

Researchers identified over 60% of bats in Japan's Yamaguchi prefecture carrying multiple zoonotic viruses, including 10 novel herpesviruses, highlighting rapid viral evolution and migration risks.

26 Sep 2024

H5N1 avian flu found in Texas dairy cattle and milk, sparking concerns about underreported infections

Researchers at UTMB found H5N1 avian influenza virus in Texas dairy cattle and milk, highlighting potential underreporting of infections among farm workers and the need for better surveillance.

4 Aug 2024

Gene therapy trial: restored hearing in children with hereditary deafness

The safety and effectiveness of binaural adeno-associated virus 1 (AAV1)-human otoferlin (hOTOF) therapy in five children with autosomal recessive deafness 9 (DFNB9).

7 Jun 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Vitamin D receptor polymorphism found to influence COVID-19 severity

Researchers compared SNPs in the vitamin D receptor (VDR) gene between mild and severe COVID-19 patients.

7 May 2024

Genseq Selects Sapio LIMS to Power Best-in-Class Next-Generation Sequencing Services

...

From Sapio Sciences 23 Apr 2024

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

Researchers investigated the Role of Cylicins in Spermiogenesis and Male Fertility in Mice and Humans through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) Gene Editing.

30 Nov 2023

New diagnostic workflow improves detection of 5q-spinal muscular atrophy

5q-spinal muscular atrophy (5q-SMA) is one of the more common types of spinal muscular atrophy (SMA) affecting around one in ten thousand individuals worldwide.

15 Nov 2023

How next-gen sequencing is changing antibody drug discovery

New study outlines how next-generation sequencing (NGS) and machine-learning methods can revolutionize antibody discovery, particularly against SARS-CoV-2. The research demonstrates that NGS provides greater epitopic and paratopic diversity, enabling more effective identification and prioritization of therapeutic antibodies.

31 Oct 2023