Tumor Necrosis Factor News and Research

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DHA improves autism-like behaviors in a preclinical rat study

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition marked by social and communication difficulties and repetitive behaviors.

3 Nov 2026

Natural plant extract reduces cisplatin-induced kidney injury in mice

Acute kidney injury is common in hospitalized patients and rises sharply in intensive care, yet treatment options remain largely supportive.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Study identifies new target to improve ulcerative colitis treatments

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

3 Nov 2026

Eating walnuts was linked to higher IgG levels, but what does that mean for health?

A two-year randomized trial involving 474 older adults found that daily consumption of 30–60 grams of walnuts was associated with 6% higher total serum IgG concentrations compared with a control diet, with an 11% difference observed among US participants. Walnut consumption did not significantly affect IgM, MDA-LDL or MDA-LDL-specific antibodies, and whether the modest IgG difference has meaningful cardiovascular benefits remains unknown.

1 Nov 2026

Skin organoids reveal how herpes simplex virus spreads between cells

Researchers at the Max Delbrück Center and University Medical Center Hamburg-Eppendorf have traced in skin organoids, how herpes simplex virus 1 infection progresses among neighboring skin cells, deepening our understanding.

30 Oct 2026

Can broccoli sprouts help with insulin resistance? New review offers clues

A review published in the British Journal of Nutrition examines how carotenoids and bioactive compounds in Brassicaceae microgreens may influence obesity, insulin resistance, and type 2 diabetes through metabolic and inflammatory pathways. Small human trials involving broccoli sprouts have reported improvements in selected metabolic markers, but larger, longer-term studies are needed to establish their clinical benefits.

29 Oct 2026

Plasma proteins offer clues to biological aging and mortality risk

A new study published in Geromedicine has identified 17 plasma proteins associated with all-cause mortality in older adults and found that several of these proteins also track with measures of biological aging across multiple organ systems.

27 Oct 2026

INmune Bio Inc. and Quantum Computing Inc. partner to apply quantum optimization and AI to advance Alzheimer’s drug research and explore new applications for XPro

INmune Bio Inc. and Quantum Computing Inc. today announced a collaboration to apply quantum computing, artificial intelligence (AI) and data analytics to identify new potential applications for XPro (XPro1595), INmune Bio's investigational treatment for Alzheimer's disease and other disease conditions.

From INmune Bio 15 Oct 2026

Three months of yoga before surgery revealed a surprising difference in stress hormones

In a non-randomized study of 40 adults with severe obesity awaiting bariatric surgery, researchers found significantly lower plasma noradrenaline levels in yoga participants than in controls after adjusting for baseline measurements. The researchers detected no significant DNA methylation changes in three inflammatory genes and found no clear psychological or metabolic benefits.

12 Oct 2026

New framework maps the complex link between psychological status and cardiovascular health

CVD remains the leading cause of death worldwide, while the global burden of mental disorders continues to rise.

28 Sep 2026

Cancer-related DNA changes may appear in blood years before diagnosis

Researchers found that genome-wide plasma cfDNA methylation profiles collected before diagnosis contained early molecular signatures associated with future prostate and breast cancer, with prostate silencer methylation providing the stronger risk stratification. Breast enhancer signals were weaker and varied by subtype and disease stage, indicating that cfDNA methylation may have greater value for risk assessment and surveillance than as a standalone diagnostic test.

23 Sep 2026

What links smoking, body fat, mental health, genes, and heart risk? Inflammation may be part of the answer

In a large UK Biobank study, higher levels of the chronic inflammation marker GlycA were associated with smaller heart chambers, thicker heart walls, impaired diastolic function, reduced stroke volume, and a 43% higher risk of major adverse cardiovascular events in the highest versus lowest GlycA group. Genetic susceptibility also modified the associations between environmental exposures, inflammation, and cardiovascular risk, while inflammatory proteins in the IL-1, TNF, and IL-6 pathways statistically mediated several of these associations.

23 Sep 2026

Older adults with higher polyphenol intake were less likely to have mild cognitive impairment

In a cross-sectional study of 92 older Italian memory-clinic patients, higher habitual intake of total dietary (poly)phenols and several specific subclasses was associated with a lower likelihood of mild cognitive impairment (MCI). Total (poly)phenol intake was not associated with cognitive test performance or circulating inflammatory biomarkers, and the authors cautioned that the small observational study cannot establish causality.

20 Sep 2026

Sex-specific biological clocks reveal how aging differs across the body in women and men

Researchers developed 38 sex-specific biological aging clocks across 15 organ systems, finding differences between females and males in genetic architecture, molecular signatures, disease associations, and mortality patterns. Brain aging clocks were linked to progression from mild cognitive impairment to Alzheimer’s disease in both sexes and to sex-dependent cognitive trajectories among solanezumab-treated A4 participants, while the authors stressed that sex-pooled and sex-interaction models remain complementary approaches.

17 Sep 2026

Shatavari may affect more than hormones, and the gut could help explain why

A review in Nutrients examined how bioactive compounds in Asparagus racemosus (Shatavari) may influence cognitive health through the microbiota-gut-brain axis, estrogen-related signaling, neuroinflammation, oxidative stress, and neurotransmitter regulation. Evidence from computational, cellular, animal, and limited human studies suggests several plausible biological pathways, but key questions remain about bioavailability, brain exposure, dosing, and clinical efficacy.

16 Sep 2026

Scientists tested how much whole grain makes a difference. The answer was not simply “more”

A meta-analysis of 87 randomized trials found that increasing whole-grain intake was associated with improvements in several cardiometabolic risk factors, although many individual changes were small or clinically unimportant. Dose-response analyses suggested that the magnitude of the effects varied by outcome and intake level, with limited evidence at very high intakes.

16 Sep 2026

Cannabis-derived nanovesicles showed early antitumor potential in mice

Researchers developed a Cannabis sativa hairy root culture system that produced stable plant-derived nanovesicles capable of promoting dendritic cell maturation and activating T-cell responses through TLR2- and TLR4-associated signaling. Oral administration also restored selected immune responses in immunosuppressed mice and suppressed tumor growth in an E.G7 lymphoma model, providing preliminary evidence for their immunomodulatory and antitumor potential.

15 Sep 2026

Gut microbiome may reveal inflammation and future disease risk better than age

Gut microbiota composition explained more variation than chronological age in nearly all inflammatory cytokines and most physiological measures examined, with specific microbial profiles linked to markedly different patterns of inflammation across adulthood. People with the Bacteroides 2 enterotype showed an inflammaging-like profile decades earlier than other groups and had a higher risk of subsequent disease, while a high-diversity microbiota profile was associated with lower inflammation and reduced disease incidence.

9 Sep 2026

Vitamin A derivative prevents immune cell exhaustion in brain tumors

Immune cells can become exhausted after prolonged exposure to cancer, gradually losing their ability to attack tumor cells.

8 Sep 2026

Tumor Necrosis Factor News and Research

DHA improves autism-like behaviors in a preclinical rat study

Natural plant extract reduces cisplatin-induced kidney injury in mice

Compounds that give citrus fruits their scent may affect gut health

Study identifies new target to improve ulcerative colitis treatments

Eating walnuts was linked to higher IgG levels, but what does that mean for health?

Skin organoids reveal how herpes simplex virus spreads between cells

Can broccoli sprouts help with insulin resistance? New review offers clues

Plasma proteins offer clues to biological aging and mortality risk

INmune Bio Inc. and Quantum Computing Inc. partner to apply quantum optimization and AI to advance Alzheimer’s drug research and explore new applications for XPro

Three months of yoga before surgery revealed a surprising difference in stress hormones

New framework maps the complex link between psychological status and cardiovascular health

Cancer-related DNA changes may appear in blood years before diagnosis

What links smoking, body fat, mental health, genes, and heart risk? Inflammation may be part of the answer

Older adults with higher polyphenol intake were less likely to have mild cognitive impairment

Sex-specific biological clocks reveal how aging differs across the body in women and men

Shatavari may affect more than hormones, and the gut could help explain why

Scientists tested how much whole grain makes a difference. The answer was not simply “more”

Cannabis-derived nanovesicles showed early antitumor potential in mice

Gut microbiome may reveal inflammation and future disease risk better than age

Vitamin A derivative prevents immune cell exhaustion in brain tumors

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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