Cell Biology

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Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls.

16 Jan 2022

Study provides valuable insight into the developmental origins of schizophrenia

Scientists from Cardiff University have discovered new links between the breakdown in brain cell development and the risk of schizophrenia and other psychiatric disorders.

16 Jan 2022

Study shows that key parts of human immunity are shared in bacteria

The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to defend themselves against viruses, scientists at Dana-Farber Cancer Institute and in Israel have discovered.

13 Jan 2022

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

13 Jan 2022

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Metabolic differences could explain why some metastatic breast cancer cells rapidly generate tumors after migrating from primary tumors to the brain, while others linger for months or years before forming these secondary tumors, UT Southwestern scientists report in a new study.

12 Jan 2022

Newly designed biochip simplifies the process of manufacturing in vitro skin in the laboratory

Researchers from the Universidad Carlos III de Madrid, the Universidad Politécnica de Madrid (UPM) and other entities have designed a new biochip, a device that simplifies the process of manufacturing in vitro skin in the laboratory and other complex multi-layer tissues.

12 Jan 2022

UCLA study provides new insights into molecular 'crosstalk' in pancreas cancer cells

Research led by scientists at the Jonsson Comprehensive Cancer Center (JCCC) at UCLA provides new insights into molecular "crosstalk" in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.

12 Jan 2022

Discovery of new protein could lead to effective treatments for developmental, neurological disorders

Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from the embryonic stage, brain development is facilitated by the differentiation of neurons (brain cells).

12 Jan 2022

New insights into molecular mechanisms that underpin the body's natural defenses against skin cancer

A study published today in Cell Reports reveals important insights into the molecular mechanisms that underpin the body's natural defenses against the development of skin cancer.

11 Jan 2022

Bmal1 gene present in the striatum influences alcohol consumption in both male and female mice

It's a commonly heard question after New Year's: "Why do we drink the way we do?" A group of researchers has found that at least some of it has to do with a particular protein in the part of the forebrain that regulates, among other things, decision-making and reward perception.

11 Jan 2022

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures.

11 Jan 2022

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

In normal cells, electrical voltage patterns provide a blueprint for orderly growth. But with cancer, the opposite happens.

11 Jan 2022

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Northwestern Medicine investigators have discovered a novel mechanism linking an intercellular adhesion molecule with genetic inflammatory skin diseases, according to findings published in the Journal of Clinical Investigation.

11 Jan 2022

First patient-derived stem cell model developed for studying oculocutaneous albinism

Researchers at the National Eye Institute have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA).

11 Jan 2022

Modular super-enhancer regulates gene expression involved in retina development

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

11 Jan 2022

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

A team of researchers recently analyzed differential protein glyco-isoform distributions of symptomatic and asymptomatic coronavirus disease 2019 patients.

11 Jan 2022

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Biliary atresia is a rare disease that occurs when a delicate tree-like set of ducts that carry bile from the liver to the intestine becomes scarred and blocked. While some treatments can slow the damage, most children who develop biliary atresia will die without a liver transplant.

10 Jan 2022

Locust study reveals a ‘surprisingly simple’ approach to recognize an odor

Smell a cup of coffee. Smell it inside or outside; summer or winter; in a coffee shop with a scone; in a pizza parlor with pepperoni -; even at a pizza parlor with a scone! -; coffee smells like coffee.

10 Jan 2022

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

A team led by University of California, Irvine researchers has developed a new biopsy technology that can profile multiple tumor microenvironment biomarkers simultaneously, revealing cellular spatial organization and interactions that will help advance personalized disease diagnosis and treatment.

10 Jan 2022

Scientists unravel how blood cells mount the first line of defense against viruses

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defense against viruses.

10 Jan 2022

Cell Biology

Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Study provides valuable insight into the developmental origins of schizophrenia

Study shows that key parts of human immunity are shared in bacteria

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Newly designed biochip simplifies the process of manufacturing in vitro skin in the laboratory

UCLA study provides new insights into molecular 'crosstalk' in pancreas cancer cells

Discovery of new protein could lead to effective treatments for developmental, neurological disorders

New insights into molecular mechanisms that underpin the body's natural defenses against skin cancer

Bmal1 gene present in the striatum influences alcohol consumption in both male and female mice

Novel mechanisms controlling tertiary lymphoid structure formation in tumors revealed

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

First patient-derived stem cell model developed for studying oculocutaneous albinism

Modular super-enhancer regulates gene expression involved in retina development

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

Maternal transfer of healthier gut bacteria helps neonates to resist biliary atresia

Locust study reveals a ‘surprisingly simple’ approach to recognize an odor

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

Scientists unravel how blood cells mount the first line of defense against viruses

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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