Cell Biology

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Pitt researchers describe a pathway by which cells repair damaged lysosomes

Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash.

8 Sep 2022

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny.

6 Sep 2022

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Researchers at McMaster University have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.

6 Sep 2022

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

The brain's cerebral cortex is made up of distinct regions involved in myriad processes, from sensory perception to cognitive functions like memory, attention, and decision-making. University of Pittsburgh neuroscience researchers have found that the properties of one neuron subtype - somatostatin neurons - are specialized in different subregions of the cortex.

6 Sep 2022

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

New method can accurately, quickly predict which antigens will lead to strong immune response

A cell's secrets can be divulged by its surface, decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe.

5 Sep 2022

Neonatal ketone body plays key role in primordial follicle pool formation and regulates ovarian aging

Premature ovarian aging (POA) refers to an early decline in ovarian function; it is the main cause of infertility in elder women and is characterized by a markedly reduced ovarian reservoir.

5 Sep 2022

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

2 Sep 2022

UTHSC team wins $2.13 million NINDS award to study early neuron development

The National Institute of Neurological Disorders and Stroke has awarded $2.13 million to a University of Tennessee Health Science Center (UTHSC) team studying how neural cells that build a functional brain are generated during embryonic and neonatal life.

2 Sep 2022

Research shows how orderly regeneration is activated after injury

The phenomenon of regeneration was discovered over 200 years ago in the freshwater polyp Hydra. Until now, however, it was largely unclear how the orderly regeneration of lost tissues or organs is activated after injury.

2 Sep 2022

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Mitochondria are remarkable shape-shifting organelles that have long been understood as the powerhouses inside our cells.

2 Sep 2022

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

These days, dragons are keeping Game of Thrones fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded dragon Pogona vitticeps.

2 Sep 2022

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

An unusual protein structure known as a "rippled beta sheet," first predicted in 1953, has now been created in the laboratory and characterized in detail using x-ray crystallography.

2 Sep 2022

New computer model can predict how fast enzymes work

Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job. Now researchers at Chalmers University of Technology have developed a computer model that can predict how fast enzymes work, making it possible to find the most efficient living factories, as well as to study difficult diseases.

2 Sep 2022

Horizontal gene transfer plays an essential role in keeping microbiomes healthy

Biomedical engineers at Duke University have demonstrated a microbial community phenomenon that essentially equates to teaching neighbors how to complete necessary tasks by ripping out and sharing parts of the brain.

2 Sep 2022

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

Tumors have significant differences depending on the person affected, even if they are the same cancer, such as breast cancer.

1 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

New kind of synapse discovered in neurons’ tiny hairs

Scientists at HHMI's Janelia Research Campus have discovered a new kind of synapse in the tiny hairs on the surface of neurons.

1 Sep 2022

KU Leuven scientists create a new type of human cell in the lab using stem cells

Professor Vincent Pasque and his team at KU Leuven have managed to generate a new type of human cell in the lab using stem cells. The new cells closely resemble their natural counterparts in early human embryos.

1 Sep 2022

Cell Biology

Pitt researchers describe a pathway by which cells repair damaged lysosomes

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Somatostatin neurons' properties are specialized in different subregions of the cortex, finds study

Lactate may have a previously unrecognized role in fighting cancer

New method can accurately, quickly predict which antigens will lead to strong immune response

Neonatal ketone body plays key role in primordial follicle pool formation and regulates ovarian aging

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

UTHSC team wins $2.13 million NINDS award to study early neuron development

Research shows how orderly regeneration is activated after injury

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

New computer model can predict how fast enzymes work

Horizontal gene transfer plays an essential role in keeping microbiomes healthy

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

New kind of synapse discovered in neurons’ tiny hairs

KU Leuven scientists create a new type of human cell in the lab using stem cells

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

How microRNA is transforming science: From discovery to diagnostics

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