Cell Biology

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Modulating the composition of bacterial populations in the colon could enhance anti-tumor immunity

A bacterium common in the mouse gut microbiome can charge up the immune system to fight cancer cells in the colon, researchers from the University of Pittsburgh School of Medicine report today in the journal Immunity.

3 Dec 2021

Penn researchers illuminate key molecular details of T-cell exhaustion process

Specially engineered immune cells called CAR T cells have proven themselves to be a powerful weapon against blood cancers, but against solid tumors they are much less effective, due in part to a process called T-cell exhaustion.

2 Dec 2021

Cannabis vapor exposure generationally affects sperm counts and motility in mice

An intense but short-term exposure to cannabis vapor lowered sperm counts and slowed sperm movement, or motility, not only in the directly exposed male mice but also in their sons.

2 Dec 2021

Immune cells play a much larger role in the onset of allergies than previously thought

A ground-breaking discovery from the Malaghan Institute has shone a light on immune cells in the skin, suggesting they play a much larger role in the onset of allergies than first thought.

2 Dec 2021

Non-coding RNA plays a key role in regulating behavior of chromosome loops and gene expression

An important player in the healthy development of female embryos turns out also to play a key role in regulating the behavior of chromosome loops and gene expression in both sexes, according to a new study by researchers at Massachusetts General Hospital.

2 Dec 2021

NEI researchers identify unique population of B cells that tamps down the immune system

Researchers at the National Eye Institute (NEI) have identified, isolated, and characterized a unique population of B cells that tamps down the immune system, reducing chronic inflammation.

2 Dec 2021

Novel set of immune cells may have the opposite effect in multiple sclerosis, other brain conditions

A group of immune cells that normally protect against inflammation in the gastrointestinal tract may have the opposite effect in multiple sclerosis (MS) and other brain inflammation-related conditions, according to a new study by Weill Cornell Medicine and NewYork-Presbyterian researchers.

1 Dec 2021

Deactivating the cancer-causing protein by cutting off other proteins that activate it

In a line of dominos, if you take out a single piece, the last one will never fall. Similarly, a lot of pieces have to line up and be pushed at the same time in a cell to result in cancer.

1 Dec 2021

Grouping of immunological T-cell receptors may be key to identifying patients' history of infection

Grouping of pathogen-recognizing proteins on immune T cells may be key to identifying if someone has had an infection in the past, suggests a study published today in eLife.

1 Dec 2021

Study sheds light on Aβ deposition patterns in the brain from external sources

Alzheimer's disease (AD) involves the deposition of a protein called amyloid β protein (Aβ) in the brain. This protein can build up in both the functional tissues, or "parenchyma", of the brain, and in the blood vessels.

30 Nov 2021

Nanoengineers develop a new approach to effectively deliver mRNA into cells

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells.

30 Nov 2021

New method can precisely, rapidly correct genetic alterations in patient cells

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

Researchers genetically map cell types that make up the mouse iris

Johns Hopkins Medicine researchers report they have genetically mapped the cell types that make up the mouse iris — the thin disc of pigmented tissue that, in humans, gives eyes their distinct colors.

30 Nov 2021

'Biosensor barcodes' can identify and track how cancer cells 'talk' to each other

Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials.

30 Nov 2021

New strategy for antibodies to distort viruses discovered

It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells.

30 Nov 2021

Study reports first-ever modeling of the electrical activity of circadian clock neurons in diurnal species

It's no secret that jet lag and night-shift work can wreak havoc on the way our body's internal clock syncs up our daily wake-sleep cycle, known as circadian rhythm, but now researchers say they are a step closer to understanding how the brain creates behavioral rhythms optimized for diurnal, rather than nocturnal, life.

30 Nov 2021

Cell Biology

Modulating the composition of bacterial populations in the colon could enhance anti-tumor immunity

Penn researchers illuminate key molecular details of T-cell exhaustion process

Cannabis vapor exposure generationally affects sperm counts and motility in mice

Immune cells play a much larger role in the onset of allergies than previously thought

Non-coding RNA plays a key role in regulating behavior of chromosome loops and gene expression

NEI researchers identify unique population of B cells that tamps down the immune system

Novel set of immune cells may have the opposite effect in multiple sclerosis, other brain conditions

Deactivating the cancer-causing protein by cutting off other proteins that activate it

Grouping of immunological T-cell receptors may be key to identifying patients' history of infection

Study sheds light on Aβ deposition patterns in the brain from external sources

Nanoengineers develop a new approach to effectively deliver mRNA into cells

New method can precisely, rapidly correct genetic alterations in patient cells

Researchers genetically map cell types that make up the mouse iris

'Biosensor barcodes' can identify and track how cancer cells 'talk' to each other

New strategy for antibodies to distort viruses discovered

Study reports first-ever modeling of the electrical activity of circadian clock neurons in diurnal species

New method helps correct genetic alterations in the cultured patient cells rapidly

Novel approach uses PSOCT to non-invasively image the depth-resolved collagen organization

Cytomegalovirus herpesvirus can accelerate the decline of the immune system, study finds

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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