Cell Biology

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Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells.

27 Sep 2022

Study shows how a common epigenetic modification can be transmitted across multiple generations

Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism's health and development.

27 Sep 2022

New machine learning tool discovers mutational signature that links bladder cancer to tobacco smoking

Researchers at the University of California San Diego have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking.

27 Sep 2022

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Infertility is a global public health problem caused by genetic defects, lifestyle, nutrition, and factors affecting the local metabolism and microenvironment of the reproductive system.

26 Sep 2022

Researchers identify key gene network responsible for severe tooth enamel defects

Mutations in a certain molecule result in severe damage in the structure and mineral composition of tooth enamel in mice, according to a study conducted at the UZH Center of Dental Medicine.

26 Sep 2022

Viruses exploit ability to sense the environment to maximize their infective yield

New UMBC-led research in Frontiers in Microbiology suggests that viruses are using information from their environment to "decide" when to sit tight inside their hosts and when to multiply and burst out, killing the host cell. The work has implications for antiviral drug development.

23 Sep 2022

DNA nets effectively target the spike protein and detect COVID-19 virus at very low levels

Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test – and also impeding the virus from infecting cells, opening a new possible route to antiviral treatment, according to a new study.

23 Sep 2022

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

The team of Prof. Alain Vanderplasschen, virologist and immunologist at the University of Liège, has published an article in the journal Nucleic Acids Research, reporting ten years of research on how a carp virus has been using a protein domain called Zalpha (Zα) to inhibit the defense mechanisms of the host cell.

23 Sep 2022

Shape-shifting fat cells offer a fertile soil for breast tumor invasion and growth

Fat cells, or adipocytes, that grow in close proximity to breast cancers can shift into other cell types that promote tumor growth, a new study by UT Southwestern researchers suggests.

23 Sep 2022

UCLA scientists receive $10 million to shed light on the developing brain's cellular infrastructure

Two scientists at the David Geffen School of Medicine at UCLA have been awarded nearly $10 million from the National Institutes of Health's Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative for research projects that aim to shed light on the developing brain's cellular infrastructure to better understand brain disorders.

22 Sep 2022

Salk scientists launch a new Center for Multiomic Human Brain Cell Atlas with $126 million NIH grant

With a five-year, $126 million grant from the National Institutes of Health, a team led by Salk Institute scientists has launched a new Center for Multiomic Human Brain Cell Atlas.

22 Sep 2022

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

A team led by Scripps Research scientists has uncovered key details of an immune-cell process that frequently underlies excessive inflammation in the body.

22 Sep 2022

New genetic discovery improves understanding of congenital heart disease

A new study led by the Masonic Medical Research Institute published in the journal Cells shows for the first time that a particular gene, called VGLL4, is required for embryo development but is dispensable for myocardial growth.

21 Sep 2022

Researchers successfully deliver a common blood pressure drug directly to cells’ ‘power plants’

In a study using lab-grown cells, Johns Hopkins Medicine researchers specializing in aging report they have successfully delivered a common blood pressure drug directly to the inner membrane of mitochondria, the "power plants" in the cells of humans, animals, plants and most other organisms.

20 Sep 2022

Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance

Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.

20 Sep 2022

Research reveals the role of microglia-neuron connections during brain development

The Laboratory of Neuroimmunology of the Institute of Experimental Medicine, Budapest, Hungary, led by Ádám Dénes, describes the presence of a direct interaction site between microglial cells and the cell body of developing neurons, and reveals its role during brain development.

20 Sep 2022

Sensory nerve cells in human skin play an important role in pigmentation

Our skin forms the physical boundary between us and the outside world, yet it still holds a surprising number of secrets.

20 Sep 2022

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumour cells evade immunotherapy by generating unique, temporary cell-in-cell structures, where the inner cells remain in tact and can return to single tumour cells.

20 Sep 2022

Humanized zebrafish could aid in the search for MS drugs

The zebrafish should be known to many aquarium enthusiasts mainly because of its striking pigmentation. However, the characteristic black-blue stripes, to which the animal owes its name, only form over time.

20 Sep 2022

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can help patients regain some mobility, but for severe cases the outcomes are extremely limited by the failure of spinal neurons to regenerate naturally after injury.

20 Sep 2022

Cell Biology

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Study shows how a common epigenetic modification can be transmitted across multiple generations

New machine learning tool discovers mutational signature that links bladder cancer to tobacco smoking

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Researchers identify key gene network responsible for severe tooth enamel defects

Viruses exploit ability to sense the environment to maximize their infective yield

DNA nets effectively target the spike protein and detect COVID-19 virus at very low levels

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

Shape-shifting fat cells offer a fertile soil for breast tumor invasion and growth

UCLA scientists receive $10 million to shed light on the developing brain's cellular infrastructure

Salk scientists launch a new Center for Multiomic Human Brain Cell Atlas with $126 million NIH grant

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

New genetic discovery improves understanding of congenital heart disease

Researchers successfully deliver a common blood pressure drug directly to cells’ ‘power plants’

Discovery of novel pathway offers a potential solution for preventing cancer chemo-resistance

Research reveals the role of microglia-neuron connections during brain development

Sensory nerve cells in human skin play an important role in pigmentation

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Humanized zebrafish could aid in the search for MS drugs

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

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