Cell Biology

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High-fat diets drive the production of inflammatory immune cells in the bone marrow of mice

Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells, according to findings published today in eLife.

20 Sep 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

Cell's anti-aging structures can set the damage threshold a cancer cell can sustain, study shows

A new study led by Claus M. Azzalin, group leader at Instituto de Medicina Molecular João Lobo Antunes- iMM and published today in the prestigious scientific journal Proceedings of the National Academy of Sciences (PNAS) shows, for the first time, that the cell's anti-aging structures – the telomeres – can set the damage threshold a cancer cell can sustain and above which cells cannot continue to divide and die.

20 Sep 2022

Endogenous exosomes act as decoys for SARS-CoV-2

A recent study published in the journal PLoS Biology discussed exosomes as potential decoys for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

20 Sep 2022

New insights into how the circadian clock may promote healing after traumatic brain injuries

A type of brain cell that can renew itself is regulated by circadian rhythms, providing significant insights into how the body's internal clock may promote healing after traumatic brain injuries (TBI), according to new research from Children's National Hospital.

19 Sep 2022

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

Elimination of transformed cells that can initiate cancer is necessary to maintain tissue integrity. In a new study, scientists from Tokyo University of Science show how this mechanism is regulated by the cellular process "autophagy."

19 Sep 2022

Researchers reveal native 3D structure of the ciliary base for the first time

Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling.

19 Sep 2022

Research uncovers novel predictors of immune checkpoint inhibitor therapy for melanoma

Immune checkpoint inhibitor (ICI) therapy is a type of treatment for melanoma, the deadliest form of skin cancer, which blocks proteins on tumor or immune cells that prevent the immune system from killing cancer cells.

19 Sep 2022

Researchers identify universal features shaping organelle gene retention

Mitochondria are compartments – so-called "organelles" -- in our cells that provide the chemical energy supply we need to move, think, and live.

16 Sep 2022

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

This study is led by Dr. Ruifu Yang, Dr. Zongmin Du (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology) and Dr. Fan Bai (Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University).

16 Sep 2022

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process.

16 Sep 2022

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

A Rochester Institute of Technology scientist hopes that a better understanding of how living cells maintain the size of their organelles can lead to therapies for neurodegenerative diseases.

16 Sep 2022

Deep AI models fail to capture the configural nature of human shape perception

Deep convolutional neural networks (DCNNs) don't see objects the way humans do – using configural shape perception – and that could be dangerous in real-world AI applications, says Professor James Elder, co-author of a York University study published today.

16 Sep 2022

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

Researchers at the University of Minnesota Medical School and the Institute on the Biology of Aging and Metabolism were awarded a total of $19.3 million in grants from the National Institutes of Health Common Fund to map senescent cells in preclinical studies and human tissues as part of the SenNet Consortium.

16 Sep 2022

Researchers use sea anemone to understand how behavior impacts body shape during early development

As humans, we know that an active lifestyle gives us some control over our form. When we hit the pavement, track our steps, and head to the gym, we can maintain muscle development and reduce body fat.

16 Sep 2022

Study evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants

The availability of rapid antigen tests has significantly advanced efforts to contain the spread of COVID-19, but every new variant of concern raises questions about whether diagnostic tests will still be effective.

15 Sep 2022

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 17, entitled, "Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study."

15 Sep 2022

New mechanism may prevent the natural aging of immune cells

A new mechanism that slows down and may even prevent the natural aging of immune cells – one of the nine 'hallmarks of aging' – has been identified by an international team led by UCL scientists.

15 Sep 2022

Scientists unravel the molecular origin of rare genetic disease cystinosis

The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations interfere with its normal function, providing insights into the underlying mechanisms and suggesting a way to develop new treatments for the disease.

15 Sep 2022

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

Researchers from Cleveland Clinic's Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a "priming signal" for the body to respond to a virus.

15 Sep 2022

Cell Biology

High-fat diets drive the production of inflammatory immune cells in the bone marrow of mice

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Cell's anti-aging structures can set the damage threshold a cancer cell can sustain, study shows

Endogenous exosomes act as decoys for SARS-CoV-2

New insights into how the circadian clock may promote healing after traumatic brain injuries

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

Researchers reveal native 3D structure of the ciliary base for the first time

Research uncovers novel predictors of immune checkpoint inhibitor therapy for melanoma

Researchers identify universal features shaping organelle gene retention

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

Deep AI models fail to capture the configural nature of human shape perception

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

Researchers use sea anemone to understand how behavior impacts body shape during early development

Study evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

New mechanism may prevent the natural aging of immune cells

Scientists unravel the molecular origin of rare genetic disease cystinosis

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

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