Cell Biology

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Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

2 May 2022

Elevated BMI may exacerbate abnormalities associated with aging sperm cells

Single-cell analysis of autopsied human testes suggests that abnormalities associated with aging sperm cells might be exacerbated by elevated body mass index (BMI).

2 May 2022

Study reveals new approach for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds.

29 Apr 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.

28 Apr 2022

UrFU researchers propose the use of polyoxometallate nanoclusters as chemotherapy drug carrier

Researchers at Ural Federal University have proposed the use of polyoxometallate nanoclusters as a carrier for chemotherapy drug. It will help to deliver medications precisely to the focus of a pathological process, such as a cancerous tumor, without toxic effects on healthy cells.

28 Apr 2022

AI system can enhance images of mouse brain cells in action

Johns Hopkins biomedical engineers have developed an artificial intelligence (AI) training strategy to capture images of mouse brain cells in action.

28 Apr 2022

New insights into how NANOG protein facilitates the activation of human cell pluripotency

There are cells in the body known as pluripotent stem cells that are yet to specialize in a particular biological function.

28 Apr 2022

Tufts scientists discover a previously unknown function performed by astrocytes

Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain.

28 Apr 2022

Sleep deprivation negatively affects the stem cells in the cornea

Sleep deprivation, which means getting too little high-quality sleep, is a serious health problem. More than one-third of people in the USA report getting less than the recommended minimum of seven hours sleep per night.

28 Apr 2022

Researchers create 3D in vitro model that reveals the origins of human spine

The spinal column is the central supporting structure of the skeleton in all vertebrates. Not only does it provide a place for muscles to attach, it also protects the spinal cord and nerve roots. Defects in its development are known to cause rare hereditary diseases.

28 Apr 2022

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

More and more mutations clutter up our DNA as we age. Mostly, these don't cause problems. But sometimes, a switch will flip, and a mutated cell turns cancerous. Can we see this shift in time to prevent or treat cancer before it starts?

28 Apr 2022

Novel plug-and-play multi-organ chip can be customized to the patient

Engineered tissues have become a critical component for modeling diseases and testing the efficacy and safety of drugs in a human context.

27 Apr 2022

Research reveals a therapeutic opportunity to prevent rhabdomyosarcoma recurrence

Rhabdomyosarcoma is a type of soft tissue cancer. Scientists at St. Jude Children's Research Hospital studied the population of cells that persists after therapy, causing rhabdomyosarcoma recurrence.

27 Apr 2022

Eukaryotes emerged in a no-oxygen environment in the ocean, research suggests

The origin of complex cells started without oxygen, new research suggests.

27 Apr 2022

Cellular reprogramming can lead to better liver tissue regeneration in mice

Mammals can't typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states - allowing them to heal damaged tissue at a faster rate than previously observed.

27 Apr 2022

Cell Biology

Study uses brain organoids to reveal how autism-linked genetic mutation disrupts neural development

Elevated BMI may exacerbate abnormalities associated with aging sperm cells

Study reveals new approach for engineering stable articular cartilage

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

UrFU researchers propose the use of polyoxometallate nanoclusters as chemotherapy drug carrier

AI system can enhance images of mouse brain cells in action

New insights into how NANOG protein facilitates the activation of human cell pluripotency

Tufts scientists discover a previously unknown function performed by astrocytes

Sleep deprivation negatively affects the stem cells in the cornea

Researchers create 3D in vitro model that reveals the origins of human spine

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

Novel plug-and-play multi-organ chip can be customized to the patient

Research reveals a therapeutic opportunity to prevent rhabdomyosarcoma recurrence

Eukaryotes emerged in a no-oxygen environment in the ocean, research suggests

Cellular reprogramming can lead to better liver tissue regeneration in mice

Discovery about human cells’ stress response could deepen the understanding of various cancers

New discovery about nature’s ‘high-end machinery’ could have big implications for biology

UNIGE scientists develop a novel tool to visualize palmitoylation process in living cells

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

How microRNA is transforming science: From discovery to diagnostics

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