Cell Biology

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Genomic Data Commons offers the largest resource in cancer genomics

The National Cancer Institute's Genomic Data Commons (GDC), launched in 2016 by then-Vice President Joseph Biden and hosted at the University of Chicago, has become one of the largest and most widely used resources in cancer genomics, with more than 3.3 petabytes of data from more than 65 projects and over 84,000 anonymized patient cases, serving more than 50,000 unique users each month.

27 Feb 2021

Well-known spasmolytic drug can suppress inflammatory response in astrocytes

Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central nervous system.

26 Feb 2021

A missing protein explains the appearance of tumor cells in people with Mulibrey syndrome

Researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), in collaboration with the Swiss Institute for Experimental Cancer Research (ISREC) have studied the mechanisms behind the higher tendency of people with Mulibrey syndrome to develop tumors.

26 Feb 2021

New 'E-Morph' test method replaces animal experiments to detect hormone-like effects

Endocrine disruptors (EDs) are hormone-like substances that can have undesirable effects on health. For example, chemicals can increase the risk of breast cancer if they act in a manner similar to the female sex hormone estrogen.

26 Feb 2021

OHSU study represents a new milestone in the field of precision medicine

Researchers at Oregon Health & Science University have demonstrated a new method of quickly mapping the genome of single cells, while also clarifying the spatial position of the cells within the body.

26 Feb 2021

Proteins play crucial role in muscle growth

When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells.

26 Feb 2021

Study reveals molecular details of SARS-CoV-2 interactions with human cells

In order to infect cells, SARS-CoV-2, the virus that causes COVID-19, needs to insert itself into the membrane of human cells. New molecular models show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets.

25 Feb 2021

Process of molecular sorting emerges from combination of two spontaneous mechanisms, indicates study

The eukaryotic cell is the basic unit of animals and plants. At the microscope, it looks highly structured and subdivided in many membrane-bound compartments.

25 Feb 2021

'Miracle poison' can target a variety of different proteins

Researchers prove they can engineer proteins called proteases to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuro-regeneration to cytokine storm.

25 Feb 2021

New book focuses on rational drug design and discovery

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery.

25 Feb 2021

Researchers discover new functions of the ENDOU enzyme

Researchers at Freiburg University discover new functions of the widely disseminated, yet little understood ENDOU enzyme.

24 Feb 2021

KTH researchers identify 300 proteins that regulate cell division process

With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins.

24 Feb 2021

Researchers discover a mechanism linked to stem cell aging

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function.

24 Feb 2021

Tumors use unique mechanism to switch on regulatory T cells for protection

Immunologists at St. Jude Children's Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system.

24 Feb 2021

SARS-CoV-2 does not infect the entire body in the same way, finds study

COVID-19, the disease caused by the pandemic coronavirus SARS-CoV-2, is primarily regarded as a respiratory infection. Yet the virus has also become known for affecting other parts of the body in ways not as well understood, sometimes with longer-term consequences, such as heart arrhythmia, fatigue and "brain fog."

24 Feb 2021

AI-based 3D holographic microscopy found to be better at analyzing cancer immunotherapy

Live tracking and analyzing of the dynamics of chimeric antigen receptor (CAR) T-cells targeting cancer cells can open new avenues for the development of cancer immunotherapy.

24 Feb 2021

In Vivo Probes for Detecting Inflammation Markers in Humans and Animals

News-Medical talks to Parry Hashemi about research on in vivo probes for detecting inflammation markers in humans and animals she will present at Pittcon.

From Pittcon 24 Feb 2021

Maturation of 'mini brain' organoids matches human brain development

A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived 'mini brain' organoids can mature in a manner that is strikingly similar to human brain development.

23 Feb 2021

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several types of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations.

23 Feb 2021

Study reveals a potential target for stroke treatment in blood-brain barrier

The blood-brain barrier prevents immune cells from circulating freely in the brain, and the breakdown of its function is a major cause of post-stroke inflammation.

23 Feb 2021