Cell Biology

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Wiggling worms offer new clues into the potential impact of diet on Alzheimer's

Worms don't wiggle when they have Alzheimer's disease. Yet something helped worms with the disease hold onto their wiggle in Professor Jessica Tanis's lab at the University of Delaware.

29 Sep 2021

RIT part of NSF-funded project to design futuristic materials inspired by biological cells

Rochester Institute of Technology Associate Professor Moumita Das is part of a team of researchers that was recently awarded a $1.8 million grant from the National Science Foundation to design and create next-generation materials inspired and empowered by biological cells.

29 Sep 2021

Novel strategy for in vitro cell-selective protection has potential for use in adoptive cell therapy

Adoptive cell therapy (ACT) is an emerging powerful cancerimmunotherapy, which includes a complex process of genetic modification, stimulation and expansion. During invitroorexvivomanipulation, sensitive cells are inescapably subjected to harmful external stimuli. Although a variety ofcytoprotectionstrategies have been developed, their application on ACT remains challenging.

29 Sep 2021

Two proteins joined together using a free-standing, rigid link

Researchers at the Paul Scherrer Institute PSI are the first to have joined two proteins together by means of a free-standing, rigid link. The structural element holds the two protein molecules together at a defined distance and angle, much the way a barbell handle connects two weights.

29 Sep 2021

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex. TDP-43 is a protein that tends to accumulate in increasing amounts, and the amount is strictly controlled by the splicing of TDP-43. Through cell experiments and analysis of human brain tissue, researchers at Brain Research Institute, Niigata University, led by Akihiro Sugai, M.D., Ph.D., have found that methylation of TDP-43 DNA is involved in the background of motor cortex involvement with aging in ALS

29 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Aging may not be due to build-up of mutations alone, study suggests

New research exploring theories of ageing has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process.

29 Sep 2021

Stringent lineage tracing is vital for nerve cell regeneration studies

UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting "striking" regeneration results must be reexamined.

29 Sep 2021

Researchers devise novel technique to count elusive circulating tumor cells

As tumors grow within an organ, they also release cells that enter the bloodstream. These cells can travel to other organs, seeding new tumors called metastases.

29 Sep 2021

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

Scientists are reporting promising results in the early stages of a clinical trial designed to gauge the feasibility of a new type of treatment for people with acute kidney disease.

28 Sep 2021

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Mutations in blood cells likely caused by smoking and aging-related changes may lead to a rare type of blood cancer that affects immune cells, shows a study published today in eLife.

28 Sep 2021

Southampton researchers invent new way to generate cartilage tissue from stem cells

Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage.

28 Sep 2021

Researchers discover working mechanism of potential drug targets for COVID-19

A team of international researchers, including McGill Professor Stéphane Laporte, have discovered the working mechanism of potential drug targets for various diseases such as cancer, rheumatoid arthritis, and even COVID-19.

28 Sep 2021

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

Cancer is a devastating disease and is the second leading cause of death in the U.S. One of the hallmarks of cancer is genomic instability, or the tendency to accumulate mutations and damage to the DNA that leads to genome alterations during cell division.

25 Sep 2021

The Lundquist Institute receives $5 million CIRM grant for a stem-cell focused program

The Lundquist Institute announced that it has received a generous $5 million, 5-year grant from the California Institute for Regenerative Medicine that will allow its PhD students, postdoctoral fellows and clinical fellows to pursue careers in stem cell biology and regenerative medicine.

24 Sep 2021

New 3D pancreatic cancer model could be used to develop and test targeted treatments

An international team of scientists have created a three-dimensional (3D) pancreatic cancer tumour model in the laboratory, combining a bioengineered matrix and patient-derived cells that could be used to develop and test targeted treatments.

24 Sep 2021

Study identifies master regulator behind the development of antibody-producing cells

The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain cancers arise.

24 Sep 2021

Researchers discover how Rift Valley fever virus enters cells

Rift Valley fever virus causes economically devastating outbreaks of hemorrhagic fever in livestock such as sheep, goats and cattle.

24 Sep 2021

New discovery offers clues to overcoming resistance to cancer therapies

Cancer cells proliferate despite a myriad of stresses - from oxygen deprivation to chemotherapy - that would kill any ordinary cell.

23 Sep 2021

Cell Biology

Wiggling worms offer new clues into the potential impact of diet on Alzheimer's

RIT part of NSF-funded project to design futuristic materials inspired by biological cells

Novel strategy for in vitro cell-selective protection has potential for use in adoptive cell therapy

Two proteins joined together using a free-standing, rigid link

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Aging may not be due to build-up of mutations alone, study suggests

Stringent lineage tracing is vital for nerve cell regeneration studies

Researchers devise novel technique to count elusive circulating tumor cells

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Southampton researchers invent new way to generate cartilage tissue from stem cells

Researchers discover working mechanism of potential drug targets for COVID-19

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

The Lundquist Institute receives $5 million CIRM grant for a stem-cell focused program

New 3D pancreatic cancer model could be used to develop and test targeted treatments

Study identifies master regulator behind the development of antibody-producing cells

Researchers discover how Rift Valley fever virus enters cells

New discovery offers clues to overcoming resistance to cancer therapies

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

How microRNA is transforming science: From discovery to diagnostics

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