Cell Biology

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Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

What is going on at the single-cell level in the first days of SARS-CoV-2 infection in the lungs?

9 Feb 2022

Research findings provide a potential roadmap for metastatic tumor formation

Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types.

9 Feb 2022

Innate immune specificity is driven by the nervous system, study suggests

Research led by Washington State University scientists supports a novel theory that the innate immune system people are born with can respond differently to specific pathogens.

9 Feb 2022

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife.

9 Feb 2022

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

A team of scientists led by Cold Spring Harbor Laboratory (CSHL) have discovered that disulfiram, an FDA-approved drug, prevents the immune system from producing toxic webs known as neutrophil extracellular traps (NETs).

8 Feb 2022

Using sugar molecules for in vivo tracking of unlabeled stem cells

A Johns Hopkins Medicine scientist who spent 30 years figuring out how to put chemical labels into cells to track their movement in living tissues has found that certain self-renewing stem cells have built-in tracers - made out of sugars - that can do the job without added chemical "labels" when injected into mouse brains.

8 Feb 2022

Selenium could boost learning and memory in aging brains

Selenium – a mineral found in many foods – could reverse the cognitive impact of stroke and boost learning and memory in aging brains, according to University of Queensland research.

7 Feb 2022

Study provides key information about the mechanism of breast cancer progression

Breast cancer is the most common cancer in women worldwide, yet despite medical advances, a cure for the tumors that spread locally and especially to distant sites remains out of reach.

7 Feb 2022

Researchers discover a new function of anti-HIV-1 antibodies

Teams at the Institut Pasteur, CNRS, Vaccine Research Institute (VRI) and Université de Paris have discovered a new function of anti-HIV-1 antibodies by applying cutting-edge microscopy techniques to in vitro viral cultures.

6 Feb 2022

Researchers investigate how messenger substances signal inflammation during damaged cell removal

A research team from Cologne and Osnabrück has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body.

4 Feb 2022

Gene therapy helps heart muscle cells electrically activate in live mice

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

4 Feb 2022

Researchers find a way to interfere with the energy pathway that promotes liver cancer spread

The World Health Organization projects that starting in 2030, over a million people will die each year from liver cancer.

4 Feb 2022

New method may be effective at quantifying DNA adenine methylation in complex organisms

For decades, a small group of cutting-edge medical researchers have been studying a biochemical, DNA tagging system, which switches genes on or off. Many have studied it in bacteria and now some have seen signs of it in, plants, flies, and even human brain tumors.

3 Feb 2022

CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

The function of an enzyme, critical to most forms of life, has been revealed.

2 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

Study discovers how long-term memory T cells are formed after SARS-CoV-2 exposure

Exposure to SARS-CoV-2 by infection or vaccination generates immune cells that provide long-term immunity. These long-lived memory T cells play a key role in preventing severe cases of Covid-19. Researchers at the University of Zurich have now discovered how these memory T cells form.

2 Feb 2022

'Genetic scissors' can give rise to unforeseen heritable mutations

CRISPR-Cas9, the "genetic scissors", creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation.

2 Feb 2022

Cell Biology

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

Research findings provide a potential roadmap for metastatic tumor formation

Innate immune specificity is driven by the nervous system, study suggests

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Researchers identify a bivalent histone-mark switch essential for angiogenesis

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

Using sugar molecules for in vivo tracking of unlabeled stem cells

Selenium could boost learning and memory in aging brains

Study provides key information about the mechanism of breast cancer progression

Researchers discover a new function of anti-HIV-1 antibodies

Researchers investigate how messenger substances signal inflammation during damaged cell removal

Gene therapy helps heart muscle cells electrically activate in live mice

Researchers find a way to interfere with the energy pathway that promotes liver cancer spread

New method may be effective at quantifying DNA adenine methylation in complex organisms

CRISPRa method helps discover genes that play a role in immune cell biology

Study offers unprecedented insight into the mechanism of action of topo VI enzyme

Three different autism risk genes found to have similar effects on brain development

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Study discovers how long-term memory T cells are formed after SARS-CoV-2 exposure

'Genetic scissors' can give rise to unforeseen heritable mutations

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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