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Scientists examine DNA repair pathways and their impact on cancer evolution

DNA repair pathways exist to correct molecular damage caused by internal and external factors. However, any damage to these pathways can result in the creation of tumors and specific types of cancers.

17 Feb 2021

Study aims to identify proteomic determinants of treatment response in malignant pleural mesothelioma

The National Cancer Institute has granted a $2.5 million, five-year R37 MERIT Award to Dr. Bryan Burt, associate professor of surgery and chief of the Division of General Thoracic Surgery, for his research project titled, "Proteomic Determinants of Response to Checkpoint Blockade in Malignant Pleural Mesothelioma."

16 Feb 2021

Novel polymer dots are a big step toward single-particle tissue imaging

A polymer that is custom designed to produce light that penetrates murky environments has shown promise in bioimaging trials, where it can detect nano-sized particles underneath the surface of realistic tissue models.

16 Feb 2021

Scientists study how a single gene alteration may have separated modern humans from extinct hominins

As a professor of pediatrics and cellular and molecular medicine at University of California San Diego School of Medicine, Alysson R. Muotri, PhD, has long studied how the brain develops and what goes wrong in neurological disorders.

15 Feb 2021

Research shows how chemicals in the tumor microenvironment enable cancer to evade attack

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

15 Feb 2021

Lipids play a regulatory role and decisively influence cell growth

Lipids are the building blocks of a cell's envelope - the cell membrane. In addition to their structural function, some lipids also play a regulatory role and decisively influence cell growth. This has been investigated in a new study by scientists at Martin Luther University Halle-Wittenberg (MLU).

15 Feb 2021

LMU researchers study T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

13 Feb 2021

Researchers map the mechanism behind cellular communication

Knowledge on how cells communicate is an important key to understanding many biological systems and diseases.

13 Feb 2021

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

SARS-CoV-2 genome is three times larger than influenza genome. Both consist of NRA molecules that mutate when replicate.

13 Feb 2021

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma.

13 Feb 2021

Major antioxidant in green tea may increase levels of natural anti-cancer protein

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

13 Feb 2021

Research provides insight into protein structures that could treat Huntington’s disease

In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein. However, it is not well known how these proteins interact with the Huntington's disease protein.

12 Feb 2021

Novel finding could lead to better treatments for Type 1 and Type 2 diabetes

Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage.

12 Feb 2021

New research aims to explore functions of bile acids in the gut stem cell niche

Examining gut health from a different angle, Flinders University’s Associate Professor Robyn Meech is looking at what can trigger colon cancer – and she believes bile acids may provide a significant piece of the puzzle.

12 Feb 2021

Disrupting cancer cell cycle with two commercially available inhibitors causes tumor cell death

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

A brain enzyme plays an important role in waking up neural stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Researchers identify protein sequences involved in SARS-CoV-2 infection

In the early days of the COVID-19 pandemic, it was established that SARS-CoV-2 infects cells by binding to the human protein ACE2, which plays a role in regulating blood pressure.

12 Feb 2021

STING activation may be a new approach to reduce graft-versus-host disease

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD).

11 Feb 2021

Researchers discover previously-unknown function in enzyme critical for cancer growth

Considered the most lethal form of DNA damage, double-strand breaks must be repaired to prevent cell death. In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways.

11 Feb 2021

Researchers find a way to measure key characteristics of proteins that bind to RNA

A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells--a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections.

11 Feb 2021

Cell Biology

Scientists examine DNA repair pathways and their impact on cancer evolution

Study aims to identify proteomic determinants of treatment response in malignant pleural mesothelioma

Novel polymer dots are a big step toward single-particle tissue imaging

Scientists study how a single gene alteration may have separated modern humans from extinct hominins

Research shows how chemicals in the tumor microenvironment enable cancer to evade attack

Lipids play a regulatory role and decisively influence cell growth

LMU researchers study T cell exhaustion

Researchers map the mechanism behind cellular communication

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Major antioxidant in green tea may increase levels of natural anti-cancer protein

Research provides insight into protein structures that could treat Huntington’s disease

Novel finding could lead to better treatments for Type 1 and Type 2 diabetes

New research aims to explore functions of bile acids in the gut stem cell niche

Disrupting cancer cell cycle with two commercially available inhibitors causes tumor cell death

A brain enzyme plays an important role in waking up neural stem cells

Researchers identify protein sequences involved in SARS-CoV-2 infection

STING activation may be a new approach to reduce graft-versus-host disease

Researchers discover previously-unknown function in enzyme critical for cancer growth

Researchers find a way to measure key characteristics of proteins that bind to RNA

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