Cell Biology

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Direct differentiation of progenitor stem-like cells into mesenchymal stem, and osteogenic cells

Epithelial cell rests of Malassez derived from the periodontal ligament were transformed into progenitor stem-like cells by stimulation with epigenetic agents.

22 Mar 2021

First model of early human embryo generated from skin cells

In a discovery that will revolutionise research into the causes of early miscarriage, infertility and the study of early human development - an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells.

22 Mar 2021

Acute exposure of lung tissue to vape aerosol has lesser impact on gene expression than cigarette smoke

A new peer-reviewed study published in the journal Toxicological Research & Application shows acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression compared to smoke from combustible cigarettes.

21 Mar 2021

Study maps structure and mechanism of a membrane enzyme that plays role in inflammation, cancer

Most drugs operate via the membranes that surround the body's cells. A study by researchers at Karolinska Institutet in Sweden has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, plays a part in chronic inflammation and cancer.

20 Mar 2021

New cellular device with computing capacity could be used outside the laboratory

The Research Group on Synthetic Biology for Biomedical Applications at Pompeu Fabra University in Barcelona, Spain, has designed a cellular device capable of computing by printing cells on paper. For the first time, they have developed a living device that could be used outside the laboratory without a specialist, and it could be produced on an industrial scale at low cost.

20 Mar 2021

Researchers describe a new approach to treating Parkinson's disease

Parkinson's disease is the second most common, age-related, neurodegenerative disease: In Germany alone, about 300,000 people are affected and experience sometimes major limitations to their quality of life.

20 Mar 2021

Newly discovered enzyme on deadly fungus may be the key to fight fungal infection

Aspergillus fumigatus kills as many people as malaria and tuberculosis, but is less known. It is found "everywhere", for example in the soil or in our compost, but is not normally dangerous to healthy people.

20 Mar 2021

Researchers unveil a neuroprotective pathway that suppresses ALS

In general, the RAN proteins are more abundant in the cell nucleus, but in patients with Lou Gehrig's disease, they begin to leak out into the cytoplasm, thereby resulting in abnormal concentration differences.

19 Mar 2021

Researchers characterize regions of DNA that impact MECP2 expression

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) have identified and characterized two regions of DNA required for the proper expression of Mecp2/MECP2 in mice and humans.

19 Mar 2021

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

Low plasma levels of protein TGFB1 and polymorphisms in gene TGFB1 act as biomarkers for the prognosis of gastric adenocarcinoma, according to a study led by the University Complutense of Madrid.

18 Mar 2021

New technique uses cell's own recycling machinery to destroy disease-causing proteins

Scientists at the University of Wisconsin-Madison have developed a way to use a cell's own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs.

18 Mar 2021

Scientists identify address codes in odorant receptor proteins

A team of scientists led by Dietmar Krautwurst from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now identified address codes in odorant receptor proteins for the first time.

17 Mar 2021

Lab-created heart valves implanted in young lambs can grow with the animal

A groundbreaking new study led by University of Minnesota Twin Cities researchers from both the College of Science and Engineering and the Medical School shows for the first time that lab-created heart valves implanted in young lambs for a year were capable of growth within the recipient.

17 Mar 2021

New method for growing embryos outside the womb

To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years.

17 Mar 2021

Researchers find a better way to identify cells and understand the mechanisms of diseases

In researching the causes and potential treatments for degenerative conditions such as Alzheimer's or Parkinson's disease, neuroscientists frequently struggle to accurately identify cells needed to understand brain activity that gives rise to behavior changes such as declining memory or impaired balance and tremors.

17 Mar 2021

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.

17 Mar 2021

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models.

17 Mar 2021

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate the structure of an elusive protein complex that plays a key role in the activation of the "Fanconi anemia pathway" involved in DNA repair, and report on the factors governing its stability.

17 Mar 2021

Study investigates how neurons construct synapses of different strengths

Job descriptions for the thousands of types of neurons in the brain typically include a common function: release chemicals called neurotransmitters to communicate across circuit connections called synapses.

17 Mar 2021

Amino acids signaling controls whole-body glucose homeostasis, study shows

Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells.

16 Mar 2021

Cell Biology

Direct differentiation of progenitor stem-like cells into mesenchymal stem, and osteogenic cells

First model of early human embryo generated from skin cells

Acute exposure of lung tissue to vape aerosol has lesser impact on gene expression than cigarette smoke

Study maps structure and mechanism of a membrane enzyme that plays role in inflammation, cancer

New cellular device with computing capacity could be used outside the laboratory

Researchers describe a new approach to treating Parkinson's disease

Newly discovered enzyme on deadly fungus may be the key to fight fungal infection

Researchers unveil a neuroprotective pathway that suppresses ALS

Researchers characterize regions of DNA that impact MECP2 expression

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

New technique uses cell's own recycling machinery to destroy disease-causing proteins

Scientists identify address codes in odorant receptor proteins

Lab-created heart valves implanted in young lambs can grow with the animal

New method for growing embryos outside the womb

Researchers find a better way to identify cells and understand the mechanisms of diseases

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

Study investigates how neurons construct synapses of different strengths

Amino acids signaling controls whole-body glucose homeostasis, study shows

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