Drug Discovery & Pharmaceuticals

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New drug-like compound could effectively block a critical step in malaria parasite life cycle

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

12 May 2021

Researchers develop a hairpin-shaped bicyclic peptide to fight cancer

The inhibition of pathological protein-protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer.

12 May 2021

Low dose of a four-drug combination helps prevent cancer metastasis in mice

Low doses of a four-drug combination helps prevent the spread of cancer in mice without triggering drug resistance or recurrence, shows a study published today in eLife.

11 May 2021

New approach targeting viral RNA could lead to broad spectrum anti-viral drugs

A new approach to tackling viruses by targeting the 'control center' in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defense against future pandemics, according to new research at the University of Birmingham.

11 May 2021

Researchers reach new milestone in the development of effective malaria vaccine

Sanaria PfSPZ-CVac" is a live vaccine consisting of infectious Plasmodium falciparum (Pf) malaria parasites that are injected into the subject at the same time as they receive an antimalarial drug.

5 May 2021

New combination treatment could benefit T-ALL patients who do not respond to chemotherapy

T-cell acute lymphoblastic leukemia is an aggressive cancer type that mostly affects children. The standard treatment is chemotherapy, but about one in four patients do not respond or develop resistance to this.

4 May 2021

New genetically encoded sensor helps detect drugs of abuse

A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell.

29 Apr 2021

New compound could alleviate neurological symptoms of CHARGE syndrome

CHARGE syndrome is a rare genetic disorder affecting about 1 in 10,000 newborns. It can lead to neurological and behavioural disorders for which no treatment is currently available.

28 Apr 2021

Cholestenone could be a new antibacterial drug against H. pylori

Helicobacter pylori (H. pylori), a gram-negative pathogen that has infected half of the world's population is a Group I carcinogen according to the WHO. H. pylori resides in the gastric mucosa causing gastritis, ulcers, gastric cancers and malignant lymphoma of the stomach.

27 Apr 2021

Study may provide a basis for oral insulin development using DNP peptides

Researchers from Kumamoto University, Japan have found that DNP peptide, a small intestine-permeable cyclic peptide originally used as an insulin additive to improve absorption into the small intestinal, lowers blood glucose levels in mice.

26 Apr 2021

Study characterizes anti-inflammatory effect of strawberry geranium on the skin

Strawberry geranium (Saxifraga stolonifera) has been used in Japan as a herbal medicine to treat wounds and swelling, and continues to be an ingredient in food and cosmetics.

23 Apr 2021

Researchers develop a method of fabrication for biodegradable polymer microcapsules

An international team led by a Skoltech researcher has developed a method of fabrication for biodegradable polymer microcapsules, made more efficient by turning to an unusual source of inspiration - traditional Russian dumpling, or pelmeni, making.

23 Apr 2021

Drug-discovery collaboration finds potential new antimalarial drug candidates

Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.

22 Apr 2021

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization.

21 Apr 2021

Argonne's Advanced Photon Source guided the development of new COVID-19 vaccine now in trials

Human clinical trials have begun on a new vaccine candidate that may protect against not only SARS-CoV-2, the virus that causes COVID-19, but against at least two of the variants emerging around the world.

21 Apr 2021

Asymmetric technique to synthesize aziridines in the presence of newly developed catalysts

Unless you've studied chemistry in college, it's unlikely you've come across the name aziridine. An organic compound with the molecular formula, C2H4NH, aziridines are well-known among medicinal chemists, who make use of the compound to prepare pharmaceutical drugs such as Mitomycin C, a chemotherapeutic agent known for its anti-tumor activity.

20 Apr 2021

Drug Discovery & Pharmaceuticals

New drug-like compound could effectively block a critical step in malaria parasite life cycle

Researchers develop a hairpin-shaped bicyclic peptide to fight cancer

Low dose of a four-drug combination helps prevent cancer metastasis in mice

New approach targeting viral RNA could lead to broad spectrum anti-viral drugs

Researchers reach new milestone in the development of effective malaria vaccine

New combination treatment could benefit T-ALL patients who do not respond to chemotherapy

New genetically encoded sensor helps detect drugs of abuse

New compound could alleviate neurological symptoms of CHARGE syndrome

Cholestenone could be a new antibacterial drug against H. pylori

Study may provide a basis for oral insulin development using DNP peptides

Study characterizes anti-inflammatory effect of strawberry geranium on the skin

Researchers develop a method of fabrication for biodegradable polymer microcapsules

Drug-discovery collaboration finds potential new antimalarial drug candidates

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Argonne's Advanced Photon Source guided the development of new COVID-19 vaccine now in trials

Asymmetric technique to synthesize aziridines in the presence of newly developed catalysts

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

Bristol-based new biotech company is developing ground-breaking treatments for Covid-19

New machine learning method for designing more effective antibody drugs

Linkam FDCS196 stage used in research to develop a novel transdermal delivery system for risperidone

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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