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Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care.

8 Nov 2020

VA joins Pentagon in recruiting volunteers for COVID vaccine trials

The Department of Veterans Affairs is recruiting 8,000 volunteers for the Phase 3 clinical trials of at least four COVID-19 vaccine candidates at 20 federal medical facilities across the U.S., according to officials with the VA and Operation Warp Speed, the Trump administration's initiative to fast-track a coronavirus vaccine.

6 Nov 2020

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

This new study titled, "Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model," was released online as a preprint on the bioRxiv* server, prior to undergoing the peer-review process.

2 Nov 2020

Drug combo for Type 2 diabetes continues to stay effective after two years of treatment

Patients with Type 2 diabetes often take metformin as first-line therapy to help stabilize their blood glucose.

2 Nov 2020

WHO welcomes SHINE trial results on shorter treatment for drug-susceptible TB in children

The World Health Organization's Global TB Programme welcomes the results from an important study on shortened treatment for drug-susceptible tuberculosis in children, presented at the 51st virtual Union World Conference on Lung Health.

2 Nov 2020

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Now, researchers from the University of California, San Francisco, and Stanford University, California, USA, reported a safe and potent antiseptic for use in humans named ethacridine, which effectively inhibits SARS-CoV-2 even at very low concentrations of EC50 ~ 0.08 µM. Their work has is published on the preprint server bioRxiv*.

1 Nov 2020

UIC enrolls people into phase 3 monoclonal antibody clinical trial

Researchers at the University of Illinois Chicago are now enrolling people into a phase 3 clinical trial that will test if a monoclonal antibody treatment -- administered as a series of four shots -- will help protect uninfected individuals from acquiring or getting sick from COVID-19 after someone in the household tests positive for COVID-19.

30 Oct 2020

Booster dose enhances immunogenicity of ChAdOx1 SARS-CoV-2 vaccine in aged mice

Now, a new study published on the pre-print server bioRxiv* shows that a single dose of the vaccine has induced cellular and humoral immunity in aged or older mice. A second dosage was needed to enhance the vaccine's immune response, showing that a prime-boost strategy may be an essential step to boost immunogenicity in the elderly.

30 Oct 2020

UH and CWRU announce Phase 3 trial of Astrazeneca's investigational COVID-19 vaccine

University Hospitals and Case Western Reserve University announced today that UH Cleveland Medical Center has been selected as a clinical trial site for the Phase 3 global study of an investigational vaccine against SARS-CoV-2, sponsored by AstraZeneca.

29 Oct 2020

Beat AML trial achieves primary endpoint

Patients participating in The Leukemia & Lymphoma Society's (LLS) groundbreaking precision medicine Beat AML Master Clinical Trial had superior outcomes compared to acute myeloid leukemia (AML) patients who opted for standard chemotherapy treatment, according to findings published today in the prestigious Nature Medicine journal.

28 Oct 2020

Phase II NRG Oncology trial evaluates two regimens for muscle-invasive bladder cancer

Bladder preservation with trimodality therapy can be a safe and effective alternative to cystectomy for selected patients with muscle-invasive bladder cancer.

27 Oct 2020

Preliminary analysis of photon therapy treatment group 1 shows no significant differences between arms

A preliminary analysis of photon therapy treatment group 1 from the phase II NRG Oncology clinical trial NRG-BN001 indicates that there is no statistically significant overall survival (OS) or toxicity differences between dose-intensification radiation therapy (DI-RT) using intensity-modulated radiation therapy (IMRT) and standard-dose radiation therapy (SD-RT) with temozolomide treatments for patients with newly diagnosed glioblastoma (GBM).

27 Oct 2020

Phase 1 trial results of gorilla adenovirus vaccine for COVID-19

A recent study published on the preprint server bioRxiv* in October 2020 reports the development of a novel vaccine based on a simian adenoviral vector obtained from a group C gorilla isolate called GRAd32. This could help speed up vaccine development.

26 Oct 2020

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

The results of a new clinical trial, published today in the New England Journal of Medicine, show that dexamethasone- a glucocorticoid used to treat many conditions, including rheumatic problems and severe COVID-19- can boost survival of premature babies when given to pregnant women at risk of preterm birth in low-resource settings.

23 Oct 2020

Clinical trial launched to test existing drugs for treatment of a rare blood cancer

A clinical trial designed to test existing drugs in the treatment of a rare blood cancer has been launched at the Universities of Birmingham and Warwick.

23 Oct 2020

Age can affect response to adjuvant treatment among patients with resected melanoma

Younger patients with resected melanoma had some benefit from adjuvant treatment with the anti-VEGF therapeutic bevacizumab (Avastin) while older patients with resected melanoma did not

23 Oct 2020

High-impact clinical trial results could improve kidney-related medical care

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25.

23 Oct 2020

Investigational drug offers benefits for patients with chronic kidney disease and type 2 diabetes

The findings, simultaneously published in the New England Journal of Medicine and presented at the American Society of Nephrology's Kidney Week 2020 conference, show the investigational drug finerenone had tangible renal and cardiovascular benefits for patients with chronic kidney disease and type 2 diabetes.

23 Oct 2020

Bedfont virtually opens first overseas office in Austria

On 3rd September, Bedfont hosted a virtual launch party to open their first overseas office, Bedfont GmbH, based in Salzburg, Austria. Earlier this year Bedfont announced the acquisition of its former distributor, Dr Lahner Medizintechnik, which now serves as the new GmbH headquarters.

From Bedfont® Scientific Ltd 23 Oct 2020

DNA vaccine-induced antibodies neutralize SARS-CoV-2

The coronavirus disease (COVID-19) is far from over as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to ravage across the globe. With the vast spread of the virus, many countries who reported flattening the curve over the past months have reported clusters of new cases and second waves of the outbreak.

22 Oct 2020

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Drug Trial News

Researchers launch clinical trial to assess therapeutic drug monitoring for patients with inflammatory diseases

VA joins Pentagon in recruiting volunteers for COVID vaccine trials

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

Drug combo for Type 2 diabetes continues to stay effective after two years of treatment

WHO welcomes SHINE trial results on shorter treatment for drug-susceptible TB in children

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

UIC enrolls people into phase 3 monoclonal antibody clinical trial

Booster dose enhances immunogenicity of ChAdOx1 SARS-CoV-2 vaccine in aged mice

UH and CWRU announce Phase 3 trial of Astrazeneca's investigational COVID-19 vaccine

Beat AML trial achieves primary endpoint

Phase II NRG Oncology trial evaluates two regimens for muscle-invasive bladder cancer

Preliminary analysis of photon therapy treatment group 1 shows no significant differences between arms

Phase 1 trial results of gorilla adenovirus vaccine for COVID-19

Antenatal steroids improve preterm newborn survival in low-resource settings, finds study

Clinical trial launched to test existing drugs for treatment of a rare blood cancer

Age can affect response to adjuvant treatment among patients with resected melanoma

High-impact clinical trial results could improve kidney-related medical care

Investigational drug offers benefits for patients with chronic kidney disease and type 2 diabetes

Bedfont virtually opens first overseas office in Austria

DNA vaccine-induced antibodies neutralize SARS-CoV-2

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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