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Early interferon therapy may mitigate COVID-19 severity

A recent review of COVID-19 therapies explores the utility of interferons in the battle against severe COVID-19, and concludes that they deserve further development.

26 Nov 2020

COVID-19 vaccine candidate tested preclinically at UAB poised for Phase 1 clinical study

A COVID-19 vaccine candidate that underwent extensive preclinical testing at the University of Alabama at Birmingham this spring and summer is poised for clinical testing to begin in December.

25 Nov 2020

New drug treatment could soon benefit people with rheumatoid arthritis

People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment that not only suppresses inflammation but also significantly reduces patient reported pain scores. Otilimab is a monoclonal antibody, biologic drug, which targets and suppresses the inflammatory cytokine GM-CSF.

25 Nov 2020

Mefloquine shows potential as anti-SARS-CoV-2 drug

A team of scientists from Japan has identified the approved anti-material drug, mefloquine, as a potential candidate to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Specifically, mefloquine has been shown to prevent the entry of SARS-CoV-2 into host cells and reduce the viral load in vitro.

24 Nov 2020

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

Thirteen African countries and an international network of research institutions have joined forces to launch the largest COVID-19 clinical trial in mild-to-moderate outpatients in Africa.

24 Nov 2020

Marinomed to initiate clinical trial with Carragelose for preventing COVID19 in frontline healthcare staff

Marinomed Biotech AG, a globally operating biopharmaceutical company, announced today plans to initiate a Phase IV clinical trial with Carragelose (iota-carrageenan).

23 Nov 2020

Favorable clinical outcome for ivermectin in COVID-19 animal model

A team of researchers at the Institut Pasteur in France has found that ivermectin prevented clinical deterioration in infected animals. The drug also reduced the inflammatory cytokines, interleukin-6 and 10 (IL-6 and IL-10) in lung tissue, which leads to more favorable clinical outcomes in treated animals.

23 Nov 2020

The Prospects of Semaglutide for Treatment of Type 2 Diabetes Patients

In this interview, News-Medical talks to Dr. Jan Westerink about recent studies into Novo Nordisk’s semaglutide and its potential benefits for Type 2 Diabetes patients, that he and Novo Nordisk collaborated on.

From Syneos Health 20 Nov 2020

Sinovac Biotech's COVID-19 vaccine candidate triggers immune response

Now, Sinovac Biotech's candidate vaccine, CoronaVac, has been found to induce an immune response in healthy adults aged 18–59 years, 28 days post-vaccination. However, the level of antibodies generated was lower than in people who had recovered from the illness.

19 Nov 2020

New combination treatment for recurrent ovarian cancer shows positive outcomes

A team from Roswell Park Comprehensive Cancer Center has detailed striking findings on the effectiveness of a previously untried combination of old and new drugs as treatment for recurrent ovarian cancer.

19 Nov 2020

NIH-funded study to test emergency treatment for devastating stroke in Memphis

The University of Tennessee Health Science Center's Stroke Team is joining researchers from more than 100 hospitals worldwide to conduct a National Institutes of Health (NIH)-funded research study called FASTEST that will test the safety and efficacy of a medication called recombinant factor Vlla to prevent hemorrhage expansion in patients with strokes caused by bleeding in the brain - intracerebral hemorrhage strokes.

19 Nov 2020

New findings support current and planned clinical trials of Janssen SARS-CoV-2 vaccine

Researchers from the United States and The Netherlands have conducted a pre-clinical study supporting the initiation of a Phase 3 trial to test a two-dose regimen of the Janssen Ad26.COV2.S vaccine candidate among adult and elderly individuals.

19 Nov 2020

UK’s COVID-19 vaccine shows similar safety and immunogenicity results in healthy older adults

The UK's vaccine against SARS-CoV-2 shows similar safety and immunogenicity results in healthy older adults (aged 56 years and over) to those seen in adults aged 18-55 years.

19 Nov 2020

Alzheimer's study shows tau protein changes according to dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

UIC conducts three clinical trials to study blood clot prevention in COVID-19 patients

The University of Illinois Chicago will conduct three clinical trials for studying blood clot prevention in patients with COVID-19.

18 Nov 2020

COVID-19 during pregnancy can cause placental inflammation and impaired immunity

A new study conducted by a team of researchers at Johns Hopkins University, USA, has observed how pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show stunted antiviral immune responses.

18 Nov 2020

Investigational drug helped improve heart health in patients with chronic conditions

The investigational medication finerenone reduced the risk of heart attack, stroke, heart failure and other negative cardiovascular events in patients with chronic kidney disease and Type 2 diabetes, according to late-breaking research presented today at the American Heart Association's Scientific Sessions 2020.

17 Nov 2020

Combination of ticagrelor and aspirin reduces subsequent stroke risk in patients with heart plaque

Patients with plaque build-up in their arteries, who suffered a transient ischemic attack (TIA) or a minor ischemic stroke, also called a warning stroke, and were treated with the newer blood thinner ticagrelor plus aspirin were 27% less likely to have another stroke within 30 days, according to late-breaking research presented today at the American Heart Association's Scientific Sessions 2020.

17 Nov 2020

Novel drug reduces the risk of cardiovascular events for patients with Type 2 diabetes, kidney disease

A novel diabetes medication significantly reduces the risk of hospitalization for heart failure, heart attack and stroke, in patients with Type 2 diabetes and chronic kidney disease, according to late breaking research presented today at the American Heart Association's Scientific Sessions 2020.

17 Nov 2020

Study shows favorable impact of medication on cardiac structure and function

For the first time, medication has impacted heart muscle thickness and function for patients with the most common inherited heart condition, rather than simply addressing their symptoms.

17 Nov 2020

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Drug Trial News

Early interferon therapy may mitigate COVID-19 severity

COVID-19 vaccine candidate tested preclinically at UAB poised for Phase 1 clinical study

New drug treatment could soon benefit people with rheumatoid arthritis

Mefloquine shows potential as anti-SARS-CoV-2 drug

Largest clinical trial launched to treat mild-to-moderate COVID-19 patients in Africa

Marinomed to initiate clinical trial with Carragelose for preventing COVID19 in frontline healthcare staff

Favorable clinical outcome for ivermectin in COVID-19 animal model

The Prospects of Semaglutide for Treatment of Type 2 Diabetes Patients

Sinovac Biotech's COVID-19 vaccine candidate triggers immune response

New combination treatment for recurrent ovarian cancer shows positive outcomes

NIH-funded study to test emergency treatment for devastating stroke in Memphis

New findings support current and planned clinical trials of Janssen SARS-CoV-2 vaccine

UK’s COVID-19 vaccine shows similar safety and immunogenicity results in healthy older adults

Alzheimer's study shows tau protein changes according to dementia stage

UIC conducts three clinical trials to study blood clot prevention in COVID-19 patients

COVID-19 during pregnancy can cause placental inflammation and impaired immunity

Investigational drug helped improve heart health in patients with chronic conditions

Combination of ticagrelor and aspirin reduces subsequent stroke risk in patients with heart plaque

Novel drug reduces the risk of cardiovascular events for patients with Type 2 diabetes, kidney disease

Study shows favorable impact of medication on cardiac structure and function

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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