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Hydroxychloroquine does not prevent COVID-19 in health care workers, trial shows

University of Minnesota Medical School physician researchers studied hydroxychloroquine as a treatment to prevent COVID-19 for those with high-risk for exposure to the virus - health care workers.

21 Oct 2020

First COPD patient treated with RejuvenAir System in a multicenter clinical trial

Temple University Hospital has treated the first patient in a multicenter international clinical trial utilizing the RejuvenAir System for the treatment of patients suffering from moderate to severe chronic obstructive pulmonary disease with chronic bronchitis.

21 Oct 2020

Promising interim results for Sinopharm's inactivated whole-virion SARS-CoV-2 vaccine

The COVID-19 pandemic has led to intensive scientific efforts to bring about an effective vaccine for global distribution. Many different vaccine design approaches are underway. A recent study published in the journal The Lancet Infectious Diseases in October 2020 reports a potentially successful inactivated virus vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

19 Oct 2020

Sinopharm's candidate SARS-CoV-2 vaccine BBIBP-CorV shows promise in clinical trials

Researchers in China have conducted a phase 1/2 trial demonstrating the safety, tolerability, and immunogenicity of a candidate vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

18 Oct 2020

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

A large-scale randomized trial has recently been conducted by the World Health Organization (WHO) to evaluate the efficacy of four repurposed antiviral medicines, including Remdesivir, Hydroxychloroquine, Lopinavir, and Interferon, currently used to treat hospitalized coronavirus disease 2019 (COVID-19) patients.

18 Oct 2020

Experimental ALS drug shows potential to prolong patient survival

An experimental medication that was recently shown to slow the progression of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, has now demonstrated the potential to also prolong patient survival.

16 Oct 2020

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

The National Institutes of Health has launched an adaptive Phase 3 clinical trial to evaluate the safety and efficacy of three immune modulator drugs in hospitalized adults with COVID-19.

16 Oct 2020

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

In just six months, the world's largest randomized control trial on COVID-19 therapeutics has generated conclusive evidence on the effectiveness of repurposed drugs for the treatment of COVID-19.

16 Oct 2020

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

The MITHRAS randomized clinical trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair (TMVR) was not superior to conservative medical treatment with regard to the primary endpoint of change in six-minute walking distance.

16 Oct 2020

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

The COVID-19 pandemic is threatening to come back in greater intensity during the winter and fall. Faced with this threat, vaccine development efforts are entering a phase of renewed focus, attempting to identify antigens capable of eliciting protective levels of neutralizing antibodies. A new study published on the preprint server bioRxiv* in October 2020 reports on a novel mRNA vaccine candidate's performance in two animal models.

16 Oct 2020

The COVID-19 vaccine pipeline

Researchers from Mayo Clinic, United States of America, have reviewed the immunity developed against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease.

14 Oct 2020

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

In a new clinical trial, UC Davis Health will test the effectiveness and safety of REGN-COV2, the monoclonal antibody cocktail, in preventing COVID-19 in adults living with infected patients.

14 Oct 2020

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

A new study published on the preprint server bioRxiv in October 2020 shows that a combination of a new compound GNS561 and remdesivir act synergistically against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This suggests that autophagy inhibitors could be an alternative strategy for SARS-CoV-2 infection.

12 Oct 2020

Suramin shows promise as COVID-19 treatment

A new study published on the preprint server bioRxiv reports the elucidation of the mechanism of inhibition of SARS-CoV-2 by a non-nucleotide inhibitor called suramin. This is the first such compound to be shown to have such activity and shows promise for use as a repurposed drug against COVID-19.

12 Oct 2020

Nasal spray COVID-19 vaccine shows promising results in mice

With promising vaccines comes a new candidate that has shown potent pre-clinical immune responses. The vaccine, developed by scientists at the University of Alabama at Birmingham (UAB), induced a potent T-cell response at the mucus layer of the lungs, including killer CD8+ T-cells, which can recognize and kill virally infected cells.

12 Oct 2020

New trial tests the effectiveness of BCG vaccine against COVID-19

A largescale global trial designed to test the theory that the widely-used BCG vaccine could help protect against COVID-19 will soon recruit healthcare staff and care home workers in the UK.

12 Oct 2020

NIH clinical trial to test a combination treatment regimen for COVID-19

A clinical trial to test the safety, tolerability and efficacy of a combination treatment regimen for coronavirus disease 2019 (COVID-19) consisting of the antiviral remdesivir plus a highly concentrated solution of antibodies that neutralize SARS-CoV-2, the virus that causes COVID-19, has begun.

8 Oct 2020

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

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Drug Trial News

Hydroxychloroquine does not prevent COVID-19 in health care workers, trial shows

First COPD patient treated with RejuvenAir System in a multicenter clinical trial

Promising interim results for Sinopharm's inactivated whole-virion SARS-CoV-2 vaccine

Sinopharm's candidate SARS-CoV-2 vaccine BBIBP-CorV shows promise in clinical trials

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

Experimental ALS drug shows potential to prolong patient survival

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

The COVID-19 vaccine pipeline

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

Suramin shows promise as COVID-19 treatment

Nasal spray COVID-19 vaccine shows promising results in mice

New trial tests the effectiveness of BCG vaccine against COVID-19

NIH clinical trial to test a combination treatment regimen for COVID-19

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

Experimental Chinese SARS-CoV-2 vaccine appears safe in early trials

Multi-center Phase I study of anti-VISTA opens for patient enrollment

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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