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Oral apixaban as effective as dalteparin for treating blood clots in people with cancer

For people with cancer, the oral blood thinner apixaban is at least as effective as dalteparin, a low molecular weight heparin given by injection, in preventing a repeat venous thromboembolism (VTE), or blood clot, with no excess in major bleeding events, according to Phase 3 trial results presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Taking ticagrelor alone better for patients with complex heart disease

Patients with complex heart disease who stopped taking aspirin three months after the insertion of one or more coronary stents and then took the anti-platelet medication ticagrelor alone for a year had fewer episodes of bleeding and no increase in heart attacks, stroke or other adverse events caused by blockages in the arteries, compared with patients who took both aspirin and ticagrelor over the same period.

30 Mar 2020

Treatment with ticagrelor alone reduces adverse events in patients with diabetes

Patients with diabetes who stopped taking aspirin three months after the insertion of a coronary stent and then took the anti-platelet medication ticagrelor alone for a year had fewer episodes of bleeding and no increase in heart attacks, stroke or other adverse events caused by blockages in the arteries, compared with patients who took both aspirin and ticagrelor for a year.

30 Mar 2020

Low-dose rivaroxaban reduces adverse heart events in symptomatic PAD post-intervention

People with symptomatic peripheral artery disease who took the blood thinner rivaroxaban with aspirin after undergoing a procedure to treat blocked arteries in the leg (lower extremity revascularization) had a 15% reduction in the risk of major adverse limb and cardiovascular events when compared with those receiving aspirin alone, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Experimental drug could offer new treatment for people with chronic heart failure

An experimental drug recently concluded a successful third-phase clinical trial and could potentially offer a new treatment for about 300,000 Canadians who have worsening chronic heart failure.

30 Mar 2020

UC Davis launches two clinical trials to evaluate treatments for COVID-19

UC Davis Health has two clinical trials underway for hospitalized patients with severe COVID-19, the disease caused by the novel coronavirus, SARS-CoV-2.

27 Mar 2020

Fast-acting anti-malarial compound shows promise in first clinical trial

A fast-acting anti-malarial compound discovered at St. Jude Children's Research Hospital was well tolerated and showed promising anti-malarial effects in the first study in humans.

27 Mar 2020

Murdoch Children's Research Institute to roll-out clinical trial of BCG vaccine against COVID-19

Professor Kathryn North AC, Director of the Murdoch Children's Research Institute in Melbourne, Australia, has announced its infectious disease researchers are preparing to roll-out a multi-center randomized controlled clinical trial of the BCG vaccine against COVID-19.

26 Mar 2020

Clinical trial launched to investigate safety and efficacy of antiviral drug for COVID-19

Physician-scientists at four University of California Health medical centers -- UC San Diego Health, UC San Francisco, UC Irvine Health and UC Davis Health -- have begun recruiting participants for a Phase II clinical trial to investigate the safety and efficacy of treating adult patients with COVID-19 with remdesivir, an antiviral drug that has shown activity in animal models and human clinical trials of SARS-CoV, MERS-CoV, Ebola, Marburg and other viruses.

24 Mar 2020

First patients enrolled in new clinical trial to evaluate potential COVID-19 treatments

Researchers from the University of Oxford have launched a new clinical trial to test the effects of potential drug treatments for patients admitted to hospital with COVID-19. The first patients have now been recruited.

23 Mar 2020

Immunotherapy treatment shows promise for some patients with advanced rare cancers

A study conducted by researchers at The University of Texas MD Anderson Cancer Center demonstrated acceptable toxicity and anti-tumor activity in patients with four types of advanced, hard-to-treat rare cancers.

20 Mar 2020

Lopinavir and ritonavir drug combo tested in severe COVID-19

Researchers from China and the United Kingdom have collaborated to conduct a clinical trial looking at the efficacy of a combination of two anti-HIV drugs lopinavir and ritonavir to combat severe cases of COVID-19. Their study titled, “A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe COVID-19,” was published in the latest issue of the New England Journal of Medicine (NEJM).

19 Mar 2020

Three-drug combination reduces all-cause mortality in COPD patients

Once-daily treatment of patients with chronic obstructive pulmonary disease (COPD) with an inhaler combining fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) reduced all-cause mortality by 42 percent, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

18 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

mRNA vaccine against novel coronavirus goes on a trial in Seattle

A clinical trial for a vaccine to protect against the novel coronavirus commenced this Monday in the U.S.. If successful, this could mean an end to the current global pandemic of COVID-19 infections, feel experts.

16 Mar 2020

Potential breakthrough in cancer immunotherapy with gasdermin E

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present.

11 Mar 2020

Newer antiretroviral drugs may be the safest, most effective HIV treatment during pregnancy

The antiretroviral drugs dolutegravir and emtricitabine/tenofovir alafenamide fumarate (DTG+FTC/TAF) may comprise the safest and most effective HIV treatment regimen currently available during pregnancy, researchers announced today.

11 Mar 2020

Research reveals bias and stereotyping when recruiting patients for oncology clinical trials

New research reveals bias and stereotyping among clinical and research professionals who recruit patients to enroll in cancer clinical trials. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

10 Mar 2020

How effective is Gabapentin in alcohol use disorder?

A new study published in the journal JAMA Internal Medicine in March 2020 reports the striking efficacy of the drug gabapentin in helping people with alcohol use disorder (AUD) with their alcohol withdrawal symptoms.

9 Mar 2020

The research and development costs of a new drug

Many recent studies have focused on how much it costs to bring a new drug to market in the light of increasing drug prices. Estimates range from $314 million to $2.8 billion. Most of this was based on proprietary data and was, therefore, not verifiable independently, attracting much criticism.

3 Mar 2020

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Drug Trial News

Oral apixaban as effective as dalteparin for treating blood clots in people with cancer

Taking ticagrelor alone better for patients with complex heart disease

Treatment with ticagrelor alone reduces adverse events in patients with diabetes

Low-dose rivaroxaban reduces adverse heart events in symptomatic PAD post-intervention

Experimental drug could offer new treatment for people with chronic heart failure

UC Davis launches two clinical trials to evaluate treatments for COVID-19

Fast-acting anti-malarial compound shows promise in first clinical trial

Murdoch Children's Research Institute to roll-out clinical trial of BCG vaccine against COVID-19

Clinical trial launched to investigate safety and efficacy of antiviral drug for COVID-19

First patients enrolled in new clinical trial to evaluate potential COVID-19 treatments

Immunotherapy treatment shows promise for some patients with advanced rare cancers

Lopinavir and ritonavir drug combo tested in severe COVID-19

Three-drug combination reduces all-cause mortality in COPD patients

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

mRNA vaccine against novel coronavirus goes on a trial in Seattle

Potential breakthrough in cancer immunotherapy with gasdermin E

Newer antiretroviral drugs may be the safest, most effective HIV treatment during pregnancy

Research reveals bias and stereotyping when recruiting patients for oncology clinical trials

How effective is Gabapentin in alcohol use disorder?

The research and development costs of a new drug

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

How microRNA is transforming science: From discovery to diagnostics

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