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Novel clinical trial fast tracks testing of COVID-19 therapies

A novel clinical trial developed by researchers at the University of Pittsburgh School of Medicine launched today at UPMC to address one of the most important debates during the COVID-19 pandemic:

9 Apr 2020

University of Utah Health, Intermountain Healthcare launch two clinical trials to treat COVID-19 patients

Researchers from Intermountain Healthcare and University of Utah Health in Salt Lake City have launched two vital clinical trials to test the effectiveness and safety of two drugs -hydroxychloroquine (HCQ) and azithromycin - to treat patients with COVID-19 (infection with the novel coronavirus).

9 Apr 2020

Clinical trial to investigate effectiveness of antimalarial drugs for COVID-19 treatment

Washington University School of Medicine in St. Louis is launching a clinical trial for patients hospitalized with COVID-19 at Barnes-Jewish Hospital.

9 Apr 2020

Ebola drug now being tested against COVID-19

As the coronavirus pandemic claims lives and overwhelms health care systems throughout the world, scientists are closely watching several late-stage trials of the antiviral drug remdesivir.

8 Apr 2020

Preclinical trials for two coronavirus vaccine candidates commence

Scientists at CSIRO, Australia’s national science body, and the Australian Animal Health Laboratory (AAHL) in Geelong, Victoria, have commenced preclinical trials for two novel coronavirus vaccine candidates.

7 Apr 2020

Bill and Melinda Gates fund potential vaccine against COVID-19

In a race against time, teams of scientists across the world are working towards developing an effective and safe vaccine to prevent infection from the SARS-CoV-2 virus that causes COVID-19 disease.

7 Apr 2020

Antiparasitic drug Ivermectin kills coronavirus in 48 hours

Around the world, scientists race to develop a vaccine or treatment against the coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Now, a team of researchers has found that a drug already available around the world can kill the coronavirus in a lab setting in just 48 hours.

6 Apr 2020

Rush participates in clinical trial to test remdesivir as potential treatment for COVID-19

Rush University Medical Center is participating in a new clinical trial to test the effectiveness of the drug remdesivir in the treatment of coronavirus disease 2019 (COVID-19). This disease currently has no approved treatment.

6 Apr 2020

Penn-led trial to evaluate the effectiveness of HCQ in combating COVID-19 pandemic

A new trial led by the Perelman School of Medicine at the University of Pennsylvania will evaluate whether the drug hydroxychloroquine can benefit people infected with COVID-19, as well as whether taking the drug preventatively may help people avoid infection altogether.

6 Apr 2020

Experimental drug APN01 prevents COVID-19 infection in the lab

With the world gripped with the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a frantic rush to find an effective drug that can be used to treat the disease.

6 Apr 2020

Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

Montefiore Health System and Albert Einstein College of Medicine has joined a clinical trial to evaluate the experimental drug remdesivir to treat people who are hospitalized with severe COVID-19 infection.

5 Apr 2020

UIC participates in two clinical trials for COVID-19 treatments

The University of Illinois at Chicago is participating in two clinical trials for COVID-19 treatments.

2 Apr 2020

Immunotherapy may benefit mCRPC patients with specific markers of immune activation

Although metastatic castration-resistant prostate cancer typically has limited response to immunotherapy, a subset of patients with pretreatment evidence of active T-cell responses in their tumors experienced prolonged survival following treatment with ipilimumab in a Phase II trial at The University of Texas MD Anderson Cancer Center.

1 Apr 2020

FDA to trial malaria drugs Chloroquine and Hydroxychloroquine for COVID-19

The U.S. Food and Drug Administration (FDA) this week provided the necessary authorization for clinical trials of chloroquine and hydroxychloroquine for the treatment of the novel coronavirus. These two drugs have been claimed by President Donald Trump to be a potential treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes COVID-19 disease. To date, there has been no conclusive proof regarding the safety and efficacy of these drugs in COVID-19 cases, say officials.

31 Mar 2020

Novel, affordable pneumonia vaccine tested in human patients

A novel vaccine against pneumonia that is less expensive and more effective than those currently used in Brazil is being tested in human patients.

31 Mar 2020

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol to near-normal levels among patients with a rare cholesterol disorder, meeting the primary endpoint in the first randomized placebo-controlled trial of the drug, which is being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

31 Mar 2020

TWILIGHT trial: Brilinta reduces bleeding compared to dual therapy in high-risk coronary patients

Results from two subgroup analyses of the Phase IV independent TWILIGHT trial funded by AstraZeneca showed Brilinta (ticagrelor) monotherapy reduced the risk of clinically relevant bleeding over 12 months compared to aspirin plus Brilinta in high-risk coronary patients.

From AstraZeneca 30 Mar 2020

Direct oral anticoagulant more effective in lowering risk of VTE after common orthopedic surgeries

The direct oral anticoagulant rivaroxaban dramatically cut the likelihood of serious venous thromboembolism (VTE) in people recovering from lower limb orthopedic surgery requiring immobilization in comparison with enoxaparin, another anticoagulant agent, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Investigational drug vericiguat benefits patients with worsening heart failure

Patients with worsening heart failure and reduced ejection fraction who received the investigational drug vericiguat had a significantly lower rate of cardiovascular death or heart failure hospitalization compared with those receiving a placebo, based on research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

The cholesterol drug alirocumab reduced low-density lipoprotein (LDL) cholesterol by 35.6% compared to placebo in adult patients with homozygous familial hypercholesterolemia (HoFH), according to a phase three clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

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Drug Trial News

Novel clinical trial fast tracks testing of COVID-19 therapies

University of Utah Health, Intermountain Healthcare launch two clinical trials to treat COVID-19 patients

Clinical trial to investigate effectiveness of antimalarial drugs for COVID-19 treatment

Ebola drug now being tested against COVID-19

Preclinical trials for two coronavirus vaccine candidates commence

Bill and Melinda Gates fund potential vaccine against COVID-19

Antiparasitic drug Ivermectin kills coronavirus in 48 hours

Rush participates in clinical trial to test remdesivir as potential treatment for COVID-19

Penn-led trial to evaluate the effectiveness of HCQ in combating COVID-19 pandemic

Experimental drug APN01 prevents COVID-19 infection in the lab

Clinical trial to evaluate experimental COVID-19 drug is underway at Montefiore and Einstein

UIC participates in two clinical trials for COVID-19 treatments

Immunotherapy may benefit mCRPC patients with specific markers of immune activation

FDA to trial malaria drugs Chloroquine and Hydroxychloroquine for COVID-19

Novel, affordable pneumonia vaccine tested in human patients

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

TWILIGHT trial: Brilinta reduces bleeding compared to dual therapy in high-risk coronary patients

Direct oral anticoagulant more effective in lowering risk of VTE after common orthopedic surgeries

Investigational drug vericiguat benefits patients with worsening heart failure

Monoclonal antibody reduces LDL cholesterol in adult patients with HoFH

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