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Combination of radiation and immunotherapy shows promise for advanced head and neck cancers

A new phase II trial finds that a combination of radiation therapy and immunotherapy led to encouraging survival outcomes and acceptable toxicity for patients with locally advanced head and neck squamous cell carcinoma

27 Feb 2020

Pre-operative immunotherapy can elicit an immune response that shrinks oral cancers

A new clinical trial suggests that immunotherapy given before other treatments for oral cavity cancers can elicit an immune response that shrinks tumors, which could provide long-term benefit for patients.

27 Feb 2020

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

APEIRON Biologics AG, a biotechnology company with an approved product on the market as well as a broad preclinical and clinical pipeline, today announced the launch of a Pilot investigator-initiated clinical trial with APN01, a recombinant human angiotensin-converting enzyme 2, to treat patients with severe coronavirus infection in the People's Republic of China.

26 Feb 2020

Chronic cough could be eased with new drug

A pair of studies have shown that chronic cough and its distressing symptoms could be eased with the help of a new drug. Also, the drug does not have side effects that can restrict its use, explain the researchers. The results of the two studies are published in The Lancet Respiratory Medicine, and the European Respiratory Journal, respectively.

26 Feb 2020

Coronavirus vaccine trials commence

The coronavirus disease (COVID-19) outbreak has swept the world, killing 2,770 people and infecting more than 81,000. Amid the health crisis, scientists from across the globe are racing to develop novel therapies and vaccines in the hope of stemming the spread of the deadly virus.

26 Feb 2020

$Investigational drug reduces heartburn severity in patients with refractory GERD$

Investigational drug reduces heartburn severity in patients with refractory GERD

An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests.

26 Feb 2020

Clinical trial to evaluate safety, efficacy of remdesivir in adults with COVID-19 begins

A randomized, controlled clinical trial to evaluate the safety and efficacy of the investigational antiviral remdesivir in hospitalized adults diagnosed with coronavirus disease 2019 (COVID-19) has begun at the University of Nebraska Medical Center in Omaha.

25 Feb 2020

Immunotherapy drug combination effective for patients with fast-growing neuroendocrine tumors

Many patients with rare, fast-growing neuroendocrine tumors respond well to a common immunotherapy drug combination, according to the first peer-reviewed publication out of DART, short for Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors, a unique rare cancer clinical trial.

24 Feb 2020

GlobalData: Oncology is top therapy area for non-industry-sponsored clinical trials

Oncology was the top therapy area for non-industry sponsored clinical trials in 2019, making up 25.7% of all clinical trials.

21 Feb 2020

New drug offers hope for preserving brain cells for a time after stroke

After 50 years of research and the testing of over 1,000 drugs, there is new hope for preserving brain cells for a time after stroke.

21 Feb 2020

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

According to the results of a large, global study led by Yale Cancer Center researchers, even a tiny amount of a biomarker known as PD-L1 (programmed death-ligand1) can predict a long-term survival benefit from using pembrolizumab (Keytruda).

20 Feb 2020

Scientists report promising activity of novel targeted drug in patients with advanced kidney cancer

Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma (ccRCC) in patients with metastatic disease.

13 Feb 2020

Combination of two antibiotics found to be no better than one for treating MRSA blood infections

Researchers attempting to improve the treatment for methicillin-resistant Staphylococcus aureus (MRSA) blood infections have discovered the combination of two antibiotics was no better than one, and led to more adverse effects.

11 Feb 2020

Novel injectable drug for faster healing of broken bones moves closer to clinical trials

One in three adults aged 60 and over suffering from a hip fracture dies within one year. Now, a Purdue University-affiliated startup is moving closer to the start of clinical trials for a novel injectable drug that is targeted to heal broken bones faster and strengthen weak bones.

11 Feb 2020

Study to evaluate safety of PrEP and dapivirine ring in pregnant women

A woman who is eight-months pregnant is the first participant to be enrolled into a study evaluating the safety and acceptability of two different HIV prevention approaches when used during pregnancy -- the monthly dapivirine vaginal ring, which is currently under regulatory review, and a daily antiretroviral (ARV) pill called Truvada, an approach already approved in several countries and commonly referred to as PrEP, short for pre-exposure prophylaxis.

10 Feb 2020

New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

The first clinical trial specifically designed to test the safety of the monthly dapivirine vaginal ring in pregnant women has begun in southern and eastern Africa.

10 Feb 2020

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

An international clinical trial evaluating whether two investigational drugs can slow memory loss and cognitive decline in people in the early stages of a rare, inherited form of Alzheimer's disease has yielded disappointing results, an initial analysis of the data has shown.

10 Feb 2020

Common drug could mitigate risk of 'a broken heart' during bereavement

The increased risk of heart attack or "a broken heart" in early bereavement could be reduced by using common medication in a novel way, according to a world-first study led by the University of Sydney and funded by Heart Research Australia.

10 Feb 2020

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Hendra antibody trial shows promise in a world-first human clinical trial

The Hendra virus is a potent pathogen transmitted to humans from animals that cause a severe and often fatal illness in both infected horses and humans. Originating from fruit bats, the virus caused an outbreak in Australia in 1994.

4 Feb 2020

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Drug Trial News

Combination of radiation and immunotherapy shows promise for advanced head and neck cancers

Pre-operative immunotherapy can elicit an immune response that shrinks oral cancers

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

Chronic cough could be eased with new drug

Coronavirus vaccine trials commence

Investigational drug reduces heartburn severity in patients with refractory GERD

Clinical trial to evaluate safety, efficacy of remdesivir in adults with COVID-19 begins

Immunotherapy drug combination effective for patients with fast-growing neuroendocrine tumors

GlobalData: Oncology is top therapy area for non-industry-sponsored clinical trials

New drug offers hope for preserving brain cells for a time after stroke

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

Scientists report promising activity of novel targeted drug in patients with advanced kidney cancer

Combination of two antibiotics found to be no better than one for treating MRSA blood infections

Novel injectable drug for faster healing of broken bones moves closer to clinical trials

Study to evaluate safety of PrEP and dapivirine ring in pregnant women

New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

Common drug could mitigate risk of 'a broken heart' during bereavement

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

Hendra antibody trial shows promise in a world-first human clinical trial

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