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Women and older adults still vastly underrepresented in cholesterol drug trials

Although heart disease is the leading cause of death in women, and older adults are more likely to have heart and vascular disease than young people, randomized clinical trials testing medications to lower cholesterol have historically underenrolled both groups.

22 May 2020

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

Two novel biomarkers have been found to correlate with improved outcomes with immunotherapy in metastatic breast cancer and may help to identify the patients most likely to benefit from this treatment, according to exploratory studies reported at the ESMO Breast Cancer Virtual Meeting 2020.

22 May 2020

Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

PrECOG, LLC is reporting clinical efficacy and biomarker analyses from its single-arm phase two study PrE0505 for the initial treatment of patients with malignant pleural mesothelioma.

20 May 2020

FDA approves IND application by Octapharma USA for severe COVID-19 patients

The U.S. Food and Drug Administration (FDA) has approved the investigational new drug (IND) application submitted by Octapharma USA for a phase three clinical trial on the efficacy and safety of Octagam 10% [Immune Globulin Intravenous (Human)] therapy in COVID-19 patients with severe disease progression.

20 May 2020

Dana-Farber launches clinical test of blood cancer drug in COVID-19 patients

Scientists at Dana-Farber Cancer Institute have launched a clinical test of a blood cancer drug in patients infected with the COVID-19 virus. T

20 May 2020

Moderna’s coronavirus vaccine candidate shows promise in phase I trial

Moderna, who partnered with the National Institutes of Health, announced that its candidate vaccine appeared to be safe when administered to eight healthy volunteers. The vaccine also stimulated an immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19).

20 May 2020

Australian COVID-19 prevention trial begins for frontline and allied healthcare workers

COVID SHIELD is a major collaborative effort led by the Walter and Eliza Hall Institute of Medical Research in partnership with human data science company IQVIA.

19 May 2020

Modified clinical trial design to meet urgent community needs during COVID-19 pandemic

A new paper published online in the Annals of the American Thoracic Society describes a nimble, pragmatic and rigorous multicenter clinical trial design to meet urgent community needs in the face of the COVID-19 pandemic.

19 May 2020

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

The first patients have been dosed in a multi-regional Phase IIB randomized, placebo-controlled clinical trial for the treatment of hepatitis B-associated liver cancer.

19 May 2020

Global study to test whether antimalaria drug can prevent COVID-19 in health-care workers

With $9 million in philanthropic support, an international group of physicians and scientists is establishing a research network to evaluate promising therapies for COVID-19.

18 May 2020

Oxford University vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

As the world continues to grapple with the coronavirus pandemic, many scientists, institutions, and pharmaceutical companies are working hard to develop an effective vaccine.

18 May 2020

UCLA-led clinical trial to assess if hormone suppresser will reduce COVID-19 severity in men

UCLA researchers have launched a new clinical trial that uses a hormone suppresser commonly used to treat men with prostate cancer to help improve clinical outcomes for men infected with COVID-19.

15 May 2020

HVTN and HPTN initiate first clinical trial in response to COVID-19

The NIH-funded HIV Vaccine Trials Network (HVTN) and HIV Prevention Trials Network (HPTN) have initiated their first clinical trial in response to COVID-19.

15 May 2020

NIH begins clinical study to evaluate hydroxychloroquine and azithromycin for COVID-19

A clinical trial has begun to evaluate whether the malaria drug hydroxychloroquine, given together with the antibiotic azithromycin, can prevent hospitalization and death from coronavirus disease 2019 (COVID-19).

14 May 2020

New clinical trial to investigate the efficacy of ivermectin against COVID-19

Clínica Universidad de Navarra and the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, have launched a clinical trial to investigate the efficacy of ivermectin against COVID-19.

14 May 2020

ACTG initiates clinical trial to evaluate treatment for COVID-19

The AIDS Clinical Trials Group, the world's largest and longest established HIV research network, today announced the initiation of ACTG 5395, a clinical trial to evaluate whether the drug combination hydroxychloroquine and azithromycin can prevent hospitalization and death from COVID-19 (which is caused by infection with the virus SARS-CoV-2).

14 May 2020

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19).

14 May 2020

11 healthcare centers participate in clinical trial of Russian drug against novel coronavirus

Initially, the drug was developed to treat rheumatoid arthritis. BIOCAD developers receive regulatory authorization as part of the procedure approved by Decree No. 441 of the Government of the Russian Federation of April 4, 2020 since the mechanism of action of the active substance is associated with the cytokine storm, a life-threatening immune system response in patients with COVID-19.

14 May 2020

New treatment improves survival for people with common liver cancer

For the first time in over a decade, scientists have identified a first-line treatment that significantly improves survival for people with hepatocellular carcinoma, the most common type of liver cancer.

13 May 2020

UCI Health to initiate clinical trial of a drug to treat critically ill COVID-19 patients

UCI Health will initiate a clinical study of a drug to treat critically ill COVID-19 patients who face a high mortality rate because of acute inflammation that fills their lungs with fluid, a grave condition that even mechanical ventilation cannot improve.

13 May 2020

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Drug Trial News

Women and older adults still vastly underrepresented in cholesterol drug trials

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

FDA approves IND application by Octapharma USA for severe COVID-19 patients

Dana-Farber launches clinical test of blood cancer drug in COVID-19 patients

Moderna’s coronavirus vaccine candidate shows promise in phase I trial

Australian COVID-19 prevention trial begins for frontline and allied healthcare workers

Modified clinical trial design to meet urgent community needs during COVID-19 pandemic

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

Global study to test whether antimalaria drug can prevent COVID-19 in health-care workers

Oxford University vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

UCLA-led clinical trial to assess if hormone suppresser will reduce COVID-19 severity in men

HVTN and HPTN initiate first clinical trial in response to COVID-19

NIH begins clinical study to evaluate hydroxychloroquine and azithromycin for COVID-19

New clinical trial to investigate the efficacy of ivermectin against COVID-19

ACTG initiates clinical trial to evaluate treatment for COVID-19

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

11 healthcare centers participate in clinical trial of Russian drug against novel coronavirus

New treatment improves survival for people with common liver cancer

UCI Health to initiate clinical trial of a drug to treat critically ill COVID-19 patients

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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