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Pilot clinical trial tests new treatment for type 1 diabetes

Type 1 diabetes is a chronic condition in which the body's own immune system attacks and destroys beta cells in the pancreas. Once the beta cells are destroyed, the pancreas can no longer produce insulin. Currently, there is no cure for T1D and treatment focuses on managing blood sugar levels.

6 Dec 2019

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Patients with nonalcoholic steatohepatitis, a chronic liver disease and a leading cause for liver transplantation in the U.S., currently lack an approved drug therapy, but this may soon change.

6 Dec 2019

Drug used to treat Parkinson’s shows potential as a dementia treatment

Drug used to treat hallucinations and delusions in Parkinson's shows promise as treatment for dementia-related psychosis (DRP).

5 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Kidney cancer patients who had already tried two or three different treatments had improved chances of preventing cancer progression with an experimental drug called tivozanib compared to an alternative approved by the U.S. Food and Drug Administration, according to a City of Hope-led study.

4 Dec 2019

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Researchers have shown that painful endometriosis symptoms could be alleviated using an investigational cancer drug.

3 Dec 2019

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

The investigational therapeutics mAb114 and REGN-EB3 offer patients a greater chance of surviving Ebola virus disease compared to the investigational treatment ZMapp, according to published results from a clinical trial conducted in the Democratic Republic of the Congo.

2 Dec 2019

New medicine could reduce number of infants dying from AIDS

A new, strawberry-flavored, granule-form medicine may be a solution for treating infants with AIDs.

2 Dec 2019

New medicine could reduce number of infant deaths from AIDS

A new, strawberry-flavored, granule-form medicine may be a solution for treating infants with AIDs.

2 Dec 2019

Study shows potential of hydromethylthionine treatment for Alzheimer's disease

In a paper published in today's online issue of the Journal of Alzheimer's Disease (DOI 10.3233/JAD-190772), TauRx has reported unexpected results of a pharmacokinetic analysis of the relationship between treatment dose, blood levels and pharmacological activity of the drug hydromethylthionine on the brain in over 1,000 patients with mild-to-moderate Alzheimer's disease.

27 Nov 2019

Scientists record assembly of ribosomes in real time

A team of scientists from Scripps Research and Stanford University has recorded in real time a key step in the assembly of ribosomes--the complex and evolutionarily ancient "molecular machines" that make proteins in cells and are essential for all life forms.

22 Nov 2019

Combination therapy improves survival in patients with hepatocellular carcinoma

Combination therapy with the PD-L1 inhibitor atezolizumab and the VEGF inhibitor bevacizumab significantly improves overall survival and progression-free survival in patients with unresectable hepatocellular carcinoma compared to standard of care, showed results from a phase 3 study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

BrainStorm Cell Therapeutics Inc., a leader in the development of innovative autologous cellular therapies for highly debilitating neurodegenerative diseases, today announced publication of "NurOwn Phase 2 Randomized Clinical Trial in ALS: Safety, Clinical and BioMarker Results," in the international, peer-reviewed journal Neurology.

20 Nov 2019

ETVAX vaccine candidate shows promise against enterotoxigenic E. coli diarrhea

University of Gothenburg reports first successful results of the oral, inactivated vaccine candidate ETVAX against enterotoxigenic E. coli diarrhea in a placebo-controlled phase I/II study in infants and children from 6 months to 5 years of age in Bangladesh.

20 Nov 2019

Breakthrough therapy could improve health and survival in people with cystic fibrosis

Researchers at the Children's Hospital Colorado Breathing Institute, one of the largest cystic fibrosis clinical care centers in the U.S., are part of a Therapeutics Development Network that oversaw clinical trials leading to FDA approval of TRIKAFTA, a new, highly-effective CF treatment for people with CF 12 years of age and older.

20 Nov 2019

New drug 'ubrogepant' may work for migraine

A new study published in the November 19, 2019 issue of JAMA shows that a newly developed small molecule drug called ubrogepant may successfully fight migraine at doses of 25 and 50 mg, with pain relief at 2 hours with both doses, while the most troublesome symptom of migraine was held off at 2 hours post-dose with the 50 mg dose. This may help millions of migraine patients to achieve pain relief and function better.

19 Nov 2019

Longitudinal study finds no cognitive decline or memory loss related to statin use

A study has demonstrated that the rate of memory decline in users of statin, was not significantly different to a control.

19 Nov 2019

Clinical trial: Oral drug improves exercise capacity in teens with congenital heart defects

The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects.

17 Nov 2019

Experimental drug found to be effective at reducing bad cholesterol

Twice-yearly injections of an experimental cholesterol-lowering drug, inclisiran, were effective at reducing low-density lipoprotein (LDL) cholesterol, often called bad cholesterol, in patients already taking the maximum dose of statin drugs, according to data of the ORION-10 trial presented Saturday, Nov. 16, at the American Heart Association's Scientific Sessions 2019.

17 Nov 2019

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Drug Trial News

Pilot clinical trial tests new treatment for type 1 diabetes

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Drug used to treat Parkinson’s shows potential as a dementia treatment

A major step toward preventing GvHD in patients receiving bone marrow transplants

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

New medicine could reduce number of infants dying from AIDS

New medicine could reduce number of infant deaths from AIDS

Study shows potential of hydromethylthionine treatment for Alzheimer's disease

Scientists record assembly of ribosomes in real time

Combination therapy improves survival in patients with hepatocellular carcinoma

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

ETVAX vaccine candidate shows promise against enterotoxigenic E. coli diarrhea

Breakthrough therapy could improve health and survival in people with cystic fibrosis

New drug 'ubrogepant' may work for migraine

Longitudinal study finds no cognitive decline or memory loss related to statin use

Clinical trial: Oral drug improves exercise capacity in teens with congenital heart defects

Experimental drug found to be effective at reducing bad cholesterol

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