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Combination drug appears to improve lung health in patients with cystic fibrosis, but with caveats

In adolescent and adult patients with cystic fibrosis taking lumacaftor-ivacaftor (ORKAMBI), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

11 Oct 2019

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can experience significant improvements with dupilumab.

9 Oct 2019

New drug Aliskiren shows promise for heart failure patients

A study published in the International Journal of Molecular Sciences, as part of a special issue “Heart Failure: From Molecular Basis to Therapy”, in August 2019, shows that aliskiren, a drug approved by the US Food and Drug Administration (FDA), can improve survival for over 5 years, on average, and enhance life quality in patients who have been correctly diagnosed with heart failure.

9 Oct 2019

GUMC now offers three clinical trials to study treatments for LBD

Georgetown University Medical Center, a Lewy Body Dementia (LBD) Association Research Center of Excellence, is now offering three clinical trials to study new treatments for LBD, a disease often confused with Parkinson's and Alzheimer's disease.

8 Oct 2019

UTHealth: Psychedelic drug being studied to relieve treatment-resistant depression

Psilocybin, a psychedelic drug believed to help rewire the brain, is now being studied to relieve treatment-resistant depression at The University of Texas Health Science Center at Houston (UTHealth) as part of a global Phase II clinical trial.

8 Oct 2019

New experimental growth factor drug appears to prevent worsening of osteoarthritis

More than 10 percent of Americans over age 60 experience knee pain related to osteoarthritis, the most common disease of the knee joint. Osteoarthritis of the knee causes pain, activity limitation, physical disability, reduced health-related quality of life and excess mortality compared with the general population.

8 Oct 2019

Phage engineering gives antibacterial therapy a new lease of life

Researchers have been identifying and modifying known phages to fight against infectious bacteria.

4 Oct 2019

Study shows how opt-out organ donation could affect transplant waiting lists in the U.S.

Every year in the United States, about 7,500 people die while waiting for an organ transplant, and that number is expected to increase in coming years as demographics shift.

3 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A US study on DNA-based and protein HIV vaccines has shown that an antibody and cellular immune response occurs within six weeks.

2 Oct 2019

New study shows response to HIV vaccine in 6 weeks

A new study using DNA-based and protein HIV vaccines in various combinations shows that antibody and cellular immune response occurs within 6 weeks from the date of vaccination, and the combination must be administered together for the most rapid protection. This will enable more large-scale testing of the vaccine for effectiveness. About 40 million people today have HIV infections, and 1.2 million deaths a year are related to this infection.

1 Oct 2019

Triple-drug combo inhaler for asthmatics with poor symptom control

New research shows that asthmatics who have poor symptom control could be benefited by using a three-drug combination inhaler. The standard treatment for these patients is a two-drug combination of an inhaled corticosteroid (ICS) and a long acting beta 2 agonist (LABA). The third ingredient added to the mix is a long acting muscarinic antagonist, add the researchers. This combination successfully improved lung function and reduced exacerbations of asthma wrote the researchers.

1 Oct 2019

Cannabis: CBD vs THC causes lower psychiatric side-effects

A study has revealed how cannabidiol works against tetrahydrocannabinol to prevent psychiatric side effects.

1 Oct 2019

Modern chemo more effective than second targeted hormone therapy against resistant prostate cancer

A modern chemotherapy drug is more effective for men with advanced prostate cancer than a second targeted hormone therapy in patients who have stopped responding to treatment, a major clinical trial shows.

30 Sep 2019

Breast, ovarian cancer drug more effective than targeted hormone therapy in some men with prostate cancer

A drug used for breast and ovarian cancer is more effective than modern targeted hormone treatments at slowing progression and improving survival in some men with advanced prostate cancer, phase III clinical trial findings reveal.

30 Sep 2019

Intensive new combination therapy for ovarian cancer shows promising results

Researchers have found that more intensive chemotherapy maintenance for ovarian cancer could be beneficial for patients. The results of the study were presented at the ESMO Congress 2019 in Barcelona, Spain last weekend on the 28th of September.

30 Sep 2019

Triplet therapy could benefit patients with BRAF-mutant metastatic colorectal cancer

Results presented today at the ESMO Congress 2019, Barcelona 27 September - 01 October, during the second Proffered Paper Session on Gastrointestinal tumors (colorectal) by VHIO's Director, Josep Tabernero, show that the triplet combination of the BRAF inhibitor, encorafenib, MEK inhibitor, binimetinib, and EGFR inhibitor, cetuximab, not only significantly improves overall survival but also increases objective response rates compared with standard of care in patients with BRAF V600E-mutant metastatic colorectal cancer.

30 Sep 2019

Novel immunotherapy combination could provide fresh hope for patients with cervical cancer

With an estimated 570,000 cases and 311,000 deaths in 2018 worldwide, cervical cancer currently ranks as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women.

30 Sep 2019

Study: Three-drug combination improves overall survival in patients with mCRC

The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

30 Sep 2019

Adding targeted therapy drug to standard treatment benefits aggressive breast cancer patients

A study led by UCLA researchers found that adding ribociclib, a targeted therapy drug, to standard hormone therapy has been shown to significantly improve overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer, one of the most common forms of the disease.

29 Sep 2019

Combination of two immunotherapy drugs stops or reverses progression of advanced melanoma

A combination of two immunotherapy drugs, ipilimumab and nivolumab, has stopped or reversed the progression of advanced melanoma for five years or more in one in two patients, according to a study led by The Royal Marsden NHS Foundation Trust.

28 Sep 2019

Drug Trial News

Combination drug appears to improve lung health in patients with cystic fibrosis, but with caveats

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

New drug Aliskiren shows promise for heart failure patients

GUMC now offers three clinical trials to study treatments for LBD

UTHealth: Psychedelic drug being studied to relieve treatment-resistant depression

New experimental growth factor drug appears to prevent worsening of osteoarthritis

Phage engineering gives antibacterial therapy a new lease of life

Study shows how opt-out organ donation could affect transplant waiting lists in the U.S.

New study shows response to HIV vaccine in 6 weeks

New study shows response to HIV vaccine in 6 weeks

Triple-drug combo inhaler for asthmatics with poor symptom control

Cannabis: CBD vs THC causes lower psychiatric side-effects

Modern chemo more effective than second targeted hormone therapy against resistant prostate cancer

Breast, ovarian cancer drug more effective than targeted hormone therapy in some men with prostate cancer

Intensive new combination therapy for ovarian cancer shows promising results

Triplet therapy could benefit patients with BRAF-mutant metastatic colorectal cancer

Novel immunotherapy combination could provide fresh hope for patients with cervical cancer

Study: Three-drug combination improves overall survival in patients with mCRC

Adding targeted therapy drug to standard treatment benefits aggressive breast cancer patients

Combination of two immunotherapy drugs stops or reverses progression of advanced melanoma

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