Histology & Microscopy

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Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico "molecular probes" able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD).

9 Sep 2022

Using Q-bodies for imaging intracellular proteins in live cells

Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development.

9 Sep 2022

Intelligent fluorescent microscope for imaging biological events in detail

Imagine you're a PhD student with a fluorescent microscope and a sample of live bacteria. What's the best way use these resources to obtain detailed observations of bacterial division from the sample?

9 Sep 2022

Novel method can be used to study the resistance profile of bacteria that cause meningitis

A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis – an inflammation of the membranes that envelop the brain and spinal cord – are resistant to antibiotics.

6 Sep 2022

Cell Counting Without Slides to Reduce Waste and Cost

Until recently, cells were typically counted on a reusable quartz hemocytometer.

From DeNovix Inc. 1 Sep 2022

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

α-synuclein is a neuronal protein involved in functions like vesicle trafficking and neurotransmitter release. It is typically found in abundance in a healthy brain.

30 Aug 2022

Using organic metal nanohybrid structures to simultaneously identify multiple food poisoning bacteria

Osaka Metropolitan University scientists have developed a simple, rapid method to simultaneously identify multiple food poisoning bacteria, based on color differences in the scattered light by nanometer-scaled organic metal nanohybrid structures (NHs) that bind via antibodies to those bacteria.

29 Aug 2022

Microscopy technique enables visualization of unseen nanostructures within cells and tissues

Inside a living cell, proteins and other molecules are often tightly packed together. These dense clusters can be difficult to image because the fluorescent labels used to make them visible can't wedge themselves in between the molecules.

29 Aug 2022

Inactivation of particular protein complex associated with Parkinson's and anxiety disorders

Inactivation of a particular protein complex that plays a key role in keeping genes switched off leads to nerve cells not producing enough essential neurotransmitters.

29 Aug 2022

EPFL scientists uncover key mechanisms underlying the formation of protein tangles in the brain

Neurodegenerative disorders such as Alzheimer's and Parkinson's disease are associated with atypical proteins that form tangles in the brain, killing neurons.

29 Aug 2022

Cornell research offers insights into CRISPR RNA-guided Caspase system

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

25 Aug 2022

Super-resolution imaging reveals how disease causes cells to reorder their DNA incorrectly

Imagine you're trying to do a job and all of the information you need to do it is in a few books at the library.

22 Aug 2022

UT Southwestern's cryo-EM images shed light on the mechanisms behind Wnt signaling activation

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation.

16 Aug 2022

Study finds genetic alterations in healthy cells that match with the tumor cells

A new study offers the possibility of unmasking genetic mutations in an organ well before commonly-used screening techniques detect signs of cancer.

10 Aug 2022

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Personalized medicine for lung cancer using molecular-targeted drugs is common but there have been no prospective validation studies done on the usefulness of lung cancer gene panel testing using cytology samples.

8 Aug 2022

Sustainable Science; What does the future look like?

We speak to Ali Safavi, CEO and Founder of Grenova about sustainable science, the impact life sciences research is having on our planet, and the solutions they offer for laboratories to help reduce their plastic waste.

From Grenova 8 Aug 2022

Researchers develop new method for visualizing single cell protein secretion with stunning resolution

We have recently witnessed the stunning images of distant galaxies revealed by the James Webb telescope, which were previously visible only as blurry spots.

5 Aug 2022

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism.

3 Aug 2022

Innovative microscopy method reveals how neurons struggle to reach their destination in Rett syndrome models

Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain tissue models of Rett syndrome, producing new insight into how developmental deficits observed in the brains of patients with the devastating disorder may emerge.

29 Jul 2022

Researchers report near-atomic-resolution images of nitrogenase during catalysis using cryo-EM

Previously, it has been impossible to capture the high-resolution images of nitrogenase, the only enzyme capable of reducing nitrogen into ammonia, during catalytic action.

29 Jul 2022

Histology & Microscopy

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

Using Q-bodies for imaging intracellular proteins in live cells

Intelligent fluorescent microscope for imaging biological events in detail

Novel method can be used to study the resistance profile of bacteria that cause meningitis

Cell Counting Without Slides to Reduce Waste and Cost

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

Using organic metal nanohybrid structures to simultaneously identify multiple food poisoning bacteria

Microscopy technique enables visualization of unseen nanostructures within cells and tissues

Inactivation of particular protein complex associated with Parkinson's and anxiety disorders

EPFL scientists uncover key mechanisms underlying the formation of protein tangles in the brain

Cornell research offers insights into CRISPR RNA-guided Caspase system

Super-resolution imaging reveals how disease causes cells to reorder their DNA incorrectly

UT Southwestern's cryo-EM images shed light on the mechanisms behind Wnt signaling activation

Study finds genetic alterations in healthy cells that match with the tumor cells

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Sustainable Science; What does the future look like?

Researchers develop new method for visualizing single cell protein secretion with stunning resolution

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

Innovative microscopy method reveals how neurons struggle to reach their destination in Rett syndrome models

Researchers report near-atomic-resolution images of nitrogenase during catalysis using cryo-EM

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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