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Obesity leaves lasting molecular tags on the immune system

People who live with obesity are 'tagging' a memory of being overweight on a key part of the immune system - leaving people with ongoing risk of obesity-related conditions years after losing weight, according to a 10 year-long study published in EMBO Reports.

27 Apr 2026

Global debate continues over fair allocation of donor hearts

As demand for heart transplants continues to far exceed the number of available donor hearts, experts at today's 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) explored a critical question: how should this scarce, life-saving resource be allocated?

25 Apr 2026

Space research accelerates heart disease studies and tissue engineering

By studying and engineering heart tissue in the unique low-gravity environment of space, the laboratory of Arun Sharma, PhD, is uncovering new ways to protect and repair the failing heart.

25 Apr 2026

Natural compound obakulactone shows therapeutic potential for rheumatoid arthritis

A new study published in Engineering reveals that obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, exerts a therapeutic effect on rheumatoid arthritis (RA) by promoting the degradation of acyl coenzyme A thioesterase 1 (ACOT1) via the ubiquitin‒proteasome pathway and restoring the homeostasis of unsaturated fatty acids.

25 Apr 2026

New AI tools enhance diagnosis and management of kidney disease

Kidney diseases develop slowly and may not produce any obvious symptoms for a long time. The body can compensate for them so effectively that the patient remains unaware of the problem for years.

25 Apr 2026

Glycocalyx modification boosts immune cell targeting against B lymphoma

A new study published in Engineering provides mechanistic insights into live-cell glycocalyx engineering and supports the rational design of next-generation adoptive cell therapies (ACTs) against B lymphoma, addressing limitations such as high costs and restricted antigen specificity in current treatments.

25 Apr 2026

Shared brain connectivity patterns found across major neurodevelopmental disorders

Differences in brain connectivity are linked to several neurodevelopmental disorders, yet scientists still struggle to determine what changes are shared or unique to each condition.

25 Apr 2026

Traditional plant extract may treat bone and mood disorders in postmenopausal women

Postmenopausal women are at higher risk for both osteoporosis and depression, yet no single treatment effectively addresses both conditions because their shared biological basis remains poorly understood.

25 Apr 2026

Brain-Gut Health Initiative supports AI-assisted diagnosis of psychiatric disorders

Psychiatric disorders affect millions worldwide, but their diagnosis still relies on clinical observation instead of standard biological tests.

25 Apr 2026

Ultra-processed foods linked to measurable drops in human attention span

New research from Monash University, the University of São Paulo and Deakin University shows a diet high in heavily processed foods can negatively impact the brain's ability to focus and increases the risk of developing dementia.

25 Apr 2026

The heart's constant beating suppresses tumor growth in cardiac tissues

The heart's constant beating may actively suppress tumor growth in cardiac tissues, a new study reports. This is because cellular pathways in these tissues alter gene regulation in cancer cells to keep them from proliferating.

25 Apr 2026

Molecular map reveals how Down syndrome alters brain development

Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human brain development before birth - a resource that resolves longstanding contradictions in the field and could lay the groundwork for future therapeutic strategies.

25 Apr 2026

Losing weight improves heart muscle contraction in people with obesity and heart failure

In a new research report, a team of scientists led by Johns Hopkins Medicine say people with severe obesity and a common type of heart failure experience weakened heart muscles, and that losing weight may reverse some of these effects.

25 Apr 2026

New consensus statement updates guidelines for cardiac device lead management

New evidence on cardiovascular implantable electronic devices (CIED) lead management and the burgeoning development of new CIED technologies have contributed to the field's rapid evolution in the last decade.

25 Apr 2026

Researchers uncover new mechanism linking metabolism, immunity, and skeletal health

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.

25 Apr 2026

Email alerts boost valve replacement rates in older patients with aortic stenosis

New data finds older patients with severe aortic stenosis (AS) were more likely to receive aortic valve replacement (AVR) and survive when clinicians received automated email notifications with abnormal heart ultrasound results detecting AS.

25 Apr 2026

Scientists identify STING switch driving inflammation in Alzheimer’s disease

The brain has its own immune system, which detects threats and mounts a defense. A growing body of evidence has shown that in Alzheimer's disease, those immune cells are chronically overactivated, causing inflammation that damages the connections between brain cells.

24 Apr 2026

Unraveling the mystery of cognitive resilience in aging brains

Some brains resist Alzheimer's, even when the disease is already present. Researchers at the Netherlands Institute for Neuroscience have found that this likely depends on how specific brain cells, known as immature neurons, respond to damage caused by the disease.

24 Apr 2026

New strategy boosts natural killer cells to fight cancer

Scientists have developed a strategy to boost the cancer-fighting power of natural killer (NK) cells, part of the immune system's first line of defense.

24 Apr 2026

New biorepository approach advances research on sudden cardiac arrest

A cutting-edge University of Cincinnati College of Medicine study has shown how emergency medicine researchers can partner with community emergency medical services nationwide to investigate the causes of sudden cardiac arrest.

24 Apr 2026