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Microglia found to drive sleep loss in Alzheimer’s

There’s a small fire isolated in your kitchen. If you had the right tool, you might be able to put it out. But before you can, the sprinklers turn on and flood your entire house.

24 Jul 2026

Cambridge scientists solve brain puzzle behind popular obesity drugs

Cambridge scientists have solved the mystery of why both stimulating and blocking a particular 'switch' in the brain can help people lose weight – findings which could help boost the effectiveness of obesity drugs.

24 Jul 2026

Bio-inspired ear probe may enhance early hearing loss diagnosis

Binghamton University Assistant Professor Jian Zhou, PhD '18, will lead a five-year, $1.84 million project funded by the National Institutes of Health to create a dual-sensing ear canal probe that will more accurately and reliably detect otoacoustic emissions.

23 Jul 2026

Study provides a practical recall-by-genotype strategy for precision psychiatry research

Clinical biobanks that combine genomic data with electronic health records (EHRs) have become powerful resources for discovering genetic variants associated with disease.

23 Jul 2026

Engineered extracellular vesicles dramatically improve cancer detection sensitivity

Anyone afflicted with cancer will often face a long and difficult journey. The early stages of any medical intervention will necessarily include a biopsy, tissue sample collection, such as a liquid biopsy which uses a blood sample.

23 Jul 2026

Computationally designed antibody attacks previously untreatable KRAS cancer mutations

Antibodies are like "guided missiles" that find and attack cancer cells, but cancer-causing mutations inside cells have remained a "blind spot" for treatment because antibodies cannot reach them.

23 Jul 2026

Study uncovers biological differences behind co-occurring conditions of Down syndrome

In a groundbreaking new study published in Nature Communications, researchers from the University of Colorado Anschutz Linda Crnic Institute for Down Syndrome (Crnic Institute) discovered unique biological processes altered among individuals with Down syndrome who have different sets of co-occurring conditions.

23 Jul 2026

Endotrophin may reveal metabolic risks linked to changing body fat

Researchers have identified a biological marker that rises and falls as body fat changes, offering new insight into how weight gain and weight loss may influence metabolic health.

23 Jul 2026

Longer activity bouts link to lower future dementia and mental health risks

A UK Biobank analysis of 66,483 adults found that longer daily moderate-to-vigorous activity bouts and less fragmented activity were associated with lower subsequent risks of inpatient diagnoses of dementia, depression, and anxiety, independent of total activity time. In neuroimaging data from 13,108 participants, these activity patterns were also associated with more favorable brain measures, although the observational analyses cannot establish cause and effect.

23 Jul 2026

Study reveals how DNA misfolding causes congenital heart disease

Congenital heart disease is the most common birth defect, affecting approximately 1 in 100 babies born each year. One of the many causes for this disorder is having only one functional copy of the gene TBX5, instead of two healthy copies, inherited from parents.

23 Jul 2026

New model holds promise as a non-invasive, low-cost tool for MAFLD screening

Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a predominant cause of chronic liver disease, underscoring the demand for accessible, non-invasive diagnostic tools.

23 Jul 2026

Researchers link genome folding to gene activity and brain tissue organization in Alzheimer's

Researchers from Carnegie Mellon University's School of Computer Science, the University of Pittsburgh School of Medicine and the University of Washington shed new light on Alzheimer's disease that could point to new directions for treatment.

23 Jul 2026

MEK inhibition could limit T cell exhaustion and give a boost to immunotherapy

A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors.

23 Jul 2026

Study reveals high prevalence of post-pandemic fatigue and sleep disturbances

Disrupted sleep and anxiety may be an ongoing issue for many people after the pandemic, whether due to COVID-19 directly or to the stress and anxiety caused by the global pandemic, and may contribute to the fatigue commonly reported by people with Post-COVID-19 Syndrome (PCS, or 'long COVID').

23 Jul 2026

Researchers develop artery-on-a-chip platform to predict stroke risk

Predicting an individual's risk of ischemic stroke is difficult because thrombosis embolization-the process of a blood clot detaching from the area where it formed and traveling to and then sticking in another blood vessel-is based on factors that are unique to each person.

23 Jul 2026

Mass-producible immune cells fight solid human tumors in mice

Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.

23 Jul 2026

Modifiable cardiovascular risk factors linked to unstable coronary artery plaques

Cardiovascular risk factors are linked to higher risk of heart disease, but it has been unknown how they are related to abrupt closure of the coronary arteries leading to heart attack and sudden cardiac death.

23 Jul 2026

RNA-based testing can improve detection of key lung cancer biomarkers

New research has shown that RNA-based testing can improve the detection and interpretation of clinically actionable genomic alterations leading to MET exon 14 skipping in lung cancer patients—important biomarkers that may be missed by DNA-only approaches.

23 Jul 2026

Review expands the role of selenium metabolism in ferroptosis

For decades, selenium has been recognized as an essential micronutrient, and glutathione peroxidase 4 (GPX4)-a selenium-containing enzyme-has been widely regarded as the central guardian against ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation.

23 Jul 2026

Lifestyle changes improve MASLD by suppressing key molecular pathway

Lifestyle modification is the cornerstone of managing metabolic dysfunction-associated steatotic liver disease (MASLD), a growing cause of chronic liver disease worldwide.

23 Jul 2026