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Tumor splicing burden predicts treatment response in kidney cancer

Researchers at City of Hope® and TGen (part of City of Hope) have identified a significant correlation between a tumor's "splicing burden" and its clinical response to treatment for metastatic renal cell carcinoma (mRCC).

5 May 2026

Obesity and Alzheimer’s linked through early metabolic disruptions

By 2030, the population in the United States aged 65 and older is expected to reach 71 million or about 20% of Americans. This growth is likely to increase the burden of age-related diseases, particularly Alzheimer's disease (AD), affecting about 1 in 9 adults over 65.

5 May 2026

New insights into ALS progression through glial cell behavior

All the core facilities of the Cibio Department of the University of Trento are involved in a study on ALS, co-funded by Fondazione AriSla, national organizations and various donors, to better understand the molecular mechanisms of slow-progressing cases.

5 May 2026

Poor mental health linked to worse care quality and lower confidence in healthcare system

People with self-reported poorer mental health also report worse quality of care and lower confidence in healthcare systems, according to a study published May 5th in the open-access journal PLOS Medicine by Margaret E. Kruk from Washington University in St. Louis, U.S., and colleagues.

5 May 2026

Hand-held wireless probe helps surgeons identify breast cancer tumors

Breast cancer impacts over 2 million women around the world each year. Following radiotherapy or chemotherapy, breast-conserving surgery is the first line of intervention for early-stage breast cancer.

5 May 2026

AI creates detailed map of fat and muscle distribution to predict major health risks

Researchers used AI to analyze whole-body MRI scans from more than 66,000 participants to create the most detailed reference map to date of how fat and muscle are distributed in the human body across age, sex and height.

5 May 2026

U.S. bariatric surgery rates drop significantly amid GLP-1 surge

The number of metabolic and bariatric surgery procedures in the United States dropped below 200,000 in 2024 for the first time since 2020, a more than 20% decline from the prior year, according to new research presented today at the annual scientific meeting of the American Society for Metabolic and Bariatric Surgery.

5 May 2026

Bariatric surgery improves outcomes for patients with obesity and chronic kidney disease

Metabolic and bariatric surgery, also known as weight-loss surgery, dramatically improves outcomes for patients with obesity and chronic kidney disease (CKD), significantly reducing the risk of kidney failure, major cardiovascular events and death, according to new research presented here today at the annual meeting of the American Society for Metabolic and Bariatric Surgery.

5 May 2026

GLP-1 use surges as surgery rates drop for severe obesity

Drawing on electronic health records from nearly 20 million patients with severe obesity, researchers from University of California San Diego find that GLP-1 prescriptions have grown exponentially -- from less than 4,600 prescriptions in 2018 to more than 1.4 million in 2025 -- according to a new real-world analysis presented today at the annual scientific meeting of the American Society for Metabolic and Bariatric Surgery.

5 May 2026

Bariatric surgery costs significantly less than GLP-1 drugs over two years

A new real-world analysis of more than 90,000 patients with obesity and type 2 diabetes finds metabolic and bariatric surgery is costs significantly less than weekly injections of GLP-1 drugs over a two-year period, according to a new research presented today at the annual scientific meeting of the American Society for Metabolic and Bariatric Surgery.

5 May 2026

Ultrasensitive test detects protein clumps to diagnose rare dementia subtype

Dementia affects over 57 million people worldwide, a number expected to nearly double in the next 20 years.

5 May 2026

KIF13B protects heart function during sepsis by regulating lipid metabolism

Sepsis, a life-threatening condition caused by dysregulated host response to infection, remains a major cause of global mortality.

5 May 2026

Study links antimicrobial peptides to amyloid disease and neurodegeneration

For decades, antimicrobial peptides (AMPs) and amyloid-forming peptides were studied in largely separate contexts.

5 May 2026

Study reveals epigenetic adaptation of beta cells across lifespan and disease

As people age, most maintain normal blood sugar even as insulin resistance tends to rise. New research suggests that pancreatic beta cells help meet this demand through gradual epigenetic changes in regulatory regions of the genome that support beta-cell identity and function.

5 May 2026

Mapping brain circuits helps identify the causes of psychiatric symptoms

If a small stroke in one corner of the brain can tip a previously healthy person into mania or set off obsessions and compulsions where none existed before, then the circuit connected to that lesion is telling us something rare in psychiatry.

5 May 2026

Machine learning study identifies distinct subtypes of Parkinson's disease

A new study led by researchers from VIB and KU Leuven shows that Parkinson's disease can be divided into distinct subtypes, helping explain why a single treatment does not work for all patients.

5 May 2026

GADD45B promotes apoptosis in intestinal injury through DNA demethylation

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

5 May 2026

Consumption of eggs can decrease risk of Alzheimer's

Consumption of eggs is associated with a lower risk of being diagnosed with Alzheimer's Disease for those 65 years and older, according to researchers at Loma Linda University Health.

5 May 2026

GLP-1 drugs combined with surgery yield superior weight loss results

People who begin obesity treatment with glucagon-like peptide-1 receptor agonists (GLP-1s) and then undergo metabolic and bariatric surgery achieve substantially greater weight loss than with the medications alone, according to new research presented today at the annual meeting of the American Society for Metabolic and Bariatric Surgery.

5 May 2026

Study highlights breakthrough in overcoming diminishing returns of sequential IBD therapies

For patients with Crohn's disease or ulcerative colitis who have exhausted other treatment options, a new combination therapy is showing results that offer hope for one of medicine's most treatment-resistant populations, according to findings from two studies to be presented today at Digestive Disease Week® (DDW) 2026.

5 May 2026