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Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

New tool identifies older adults at risk of delirium and falls from anticholinergic medications

Researchers funded by Health Data Research UK (HDR UK) have developed a new tool to help doctors and pharmacists identify older patients at risk of delirium and serious falls associated with taking multiple anticholinergic medications.

5 Nov 2026

Tau spreads more rapidly in early-onset Alzheimer's disease

Patients with early-onset Alzheimer's disease, whose symptoms start before age 65, have more extensive deposits of tau, a hallmark protein of the condition, compared with patients whose symptoms start at 65-plus, a new study found.

5 Nov 2026

Brain scans reveal clues to Alzheimer's risk years before memory loss begins

Inside the brains of some cognitively normal adults, firing patterns were able to foretell Alzheimer's disease years before the onset of memory loss or the accumulation of plaques and tangles, according to new Stanford Medicine-led research.

5 Nov 2026

Three-drug combination remodels immune environment in gastric cancer

A triplet combination therapy can remodel the tumor microenvironment in patients with advanced gastric cancer and shows a promising safety profile, according to results from a new phase 2 clinical trial.

5 Nov 2026

Targeting brain protein may help treat MEF2C-related neurological disorders

A particular signaling protein in the brain could be a therapeutic target for neurological disorders arising from the deletion of the autism-linked gene MEF2C, University of Illinois Urbana-Champaign researchers found in a new mouse study.

4 Nov 2026

UCLA advances CRISPR gene-editing therapy for sickle cell disease

A UCLA-led team has described how they advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

4 Nov 2026

Workplace exposure to petroleum-based lubricants linked to higher MS risk

Exposure to petroleum-derived lubricants at work, including engine oil, hydraulic oil and cutting fluids used to cool or lubricate metal during metalworking, is associated with higher odds of multiple sclerosis (MS), according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Psychedelics linked to lingering visual disturbances resembling early psychosis

Every night, as he fell asleep, a 25-year-old man saw an eye in his ceiling. It was huge and unblinking, and it felt as if the whole world was being sucked into it.

4 Nov 2026

Rutgers specialist launches awareness initiative for often-misdiagnosed tailbone pain

Thousands of people suffer with tailbone pain, often struggling to find an accurate diagnosis and effective treatment.

4 Nov 2026

Inherited high cholesterol linked to slightly higher pre-eclampsia risk

Women with the inherited cholesterol condition familial hypercholesterolemia may be at a slightly higher risk of developing pre-eclampsia, a pregnancy condition that can cause serious complications, according to a new study in the European Journal of Preventive Cardiology.

4 Nov 2026

Dialysis may not be the default treatment for older kidney patients

Dialysis should not necessarily be regarded as the default option for older people with kidney failure, the first randomized study of its kind in the world, led by the University of Bristol, has found.

4 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

New nanovesicle therapy shows promise for treating alcohol-related liver disease

Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation, and extracellular matrix remodeling, yet effective therapies remain limited.

4 Nov 2026

Pulse oximeter bias undercounts sleep apnea severity in Black patients

Sleep studies often use a pulse oximeter to determine the severity of sleep apnea. But a new study by investigators from Mass General Brigham reports that pulse oximeters may undercount breathing events in Black patients, potentially leading to inaccurate severity classifications.

4 Nov 2026