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Gene therapy targeting connexin 43 shows promise across inherited heart diseases

University of California San Diego-led team has discovered that restoring a key cardiac protein called connexin‑43 in a mouse model can dramatically improve heart function and extend survival in several inherited forms of arrhythmogenic cardiomyopathy (ACM)

26 Jan 2026

Physical behavior reveals aggressive cancer cells in a simple new approach

New study shows that aggressive cancer cells can be identified in a simple, new way; by how they physically behave, not just by their genes.

26 Jan 2026

Reducing sodium in common foods could prevent heart disease and stroke

Lowering sodium in packaged and prepared foods could significantly improve cardiovascular health and prevent many cases of heart disease, stroke and deaths in the general population in France and the U.K., according to two new research studies published today in Hypertension, an American Heart Association journal.

26 Jan 2026

Minimally invasive biopsy enables real-time tracking of amyloid disease progression

Transthyretin amyloidosis (ATTR) is a rare, progressive and highly aggressive degenerative disease. It is caused by the misfolding of a specific protein, leading to its toxic accumulation in the form of filamentous deposits in various organs.

26 Jan 2026

Genetic study reveals immune-related roots of allergic conjunctivitis

Allergic conjunctivitis is one of the most common eye conditions. A new large-scale genetic study shows that susceptibility to the disease is strongly linked to genes that regulate inflammation and immune defense.

26 Jan 2026

Lifetime alcohol consumption associated with higher risk of colorectal cancer

Studies have demonstrated a link between alcohol consumption and an elevated risk of colorectal cancer. New research now reveals that higher lifetime alcohol consumption is also associated with a higher risk,

26 Jan 2026

Olive oil type matters for cognition and gut health in older adults

Higher intake of virgin and total olive oil was associated with modest but significant improvements in cognitive performance over two years in older adults with metabolic syndrome. These associations were partly linked to gut microbiota composition, with specific taxa such as Adlercreutzia contributing a small mediating effect.

26 Jan 2026

Why exercise is essential for restoring fitness after GLP-1-based weight loss

This randomized controlled trial shows that structured moderate-to-vigorous exercise, alone or combined with liraglutide, improves physical function and cardiorespiratory fitness after diet-induced weight loss in adults with obesity. In contrast, liraglutide alone sustains weight loss but does not significantly improve measured physical fitness outcomes.

26 Jan 2026

Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease

Micro- and nanoplastics are increasingly detected in human tissues, including the brain, and experimental evidence suggests they can interact with biological pathways central to Parkinson’s disease pathology. This review synthesises mechanistic data indicating that plastic particles may influence protein aggregation, neuroinflammation, mitochondrial dysfunction, and the gut–brain axis, while emphasising the need for prospective human studies.

26 Jan 2026

Three daily servings of full-fat dairy do not worsen weight or blood markers

This randomized 12-week trial examined whether adding three daily servings of full-fat dairy to diets aligned with Canada’s Food Guide affects body weight, cardiometabolic markers, and nutrient intake in adults with overweight or obesity. Full-fat dairy intake did not adversely affect weight, body composition, or metabolic health and increased calcium and protein intake, supporting dietary compatibility rather than therapeutic benefit.

26 Jan 2026

New role for GLP-1 drugs: Improving survival in people with severe psychiatric disorders

This editorial argues that GLP-1 receptor agonists could substantially improve healthspan and reduce premature mortality in people with serious mental illnesses by targeting cardiometabolic risk rather than psychiatric symptoms alone. It highlights emerging evidence, safety considerations, and equity challenges that position GLP-1 RAs as a promising public health strategy for this high-risk population.

25 Jan 2026

Evidence links gut microbiome changes to Alzheimer’s progression

Human studies consistently report gut microbiome differences in mild cognitive impairment and Alzheimer’s disease, but findings vary widely by cohort, methods, and taxa. Heterogeneity and limited longitudinal data prevent causal inference, highlighting the need for functional profiling and well-designed intervention trials.

25 Jan 2026

Why the age you start smoking matters as much as how much you smoke

Starting smoking at a younger age is associated with substantially higher risks of myocardial infarction, stroke, and death, even after accounting for cumulative smoking exposure. Early initiation also amplifies the cardiovascular harm of heavier smoking, indicating increased vulnerability when smoking begins in adolescence.

25 Jan 2026

Diagnostic prognostic and therapeutic relevance of PIVKA-II in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly in regions with high hepatitis B virus prevalence.

24 Jan 2026

Colorblindness linked to delayed bladder cancer detection and higher mortality

Recognizing the sight of blood in urine, the most common first sign of bladder cancer, is often the impetus that leads people to a diagnosis.

24 Jan 2026

Selective inhibition of cPLA2 shows promise against Alzheimer's-related brain inflammation

A multidisciplinary USC research team has identified new compounds that may target a key driver of brain inflammation linked to Alzheimer's disease. Their research just published in the Nature publication npj Drug Discovery.

24 Jan 2026

Large multi-ancestry study expands understanding of schizophrenia genetics

A landmark study led by researchers with the Department of Veterans Affairs has uncovered new genetic insights into schizophrenia by analyzing data from ancestrally diverse populations, including African Americans, through the Million Veteran Program (MVP) and Cooperative Studies Program (CSP).

24 Jan 2026

PTPN2 gene protects the gut from harmful bacteria driving inflammatory bowel disease

Two recent studies from the University of California, Riverside, published in the same issue of Gut Microbes highlight the role of a gene called PTPN2 in protecting the gut from harmful bacteria linked to inflammatory bowel disease (IBD).

24 Jan 2026

Orphan noncoding RNAs define cancer identity and enable blood-based monitoring

We knew we had something interesting with T3p, a single small RNA found in breast cancer but absent from normal tissue.

24 Jan 2026

Unraveling liver injury mechanisms in familial hypobetalipoproteinemia

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal co-dominant monogenic disorder characterized by lifelong low plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and APOB.

24 Jan 2026

Medical Condition News

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

Physical behavior reveals aggressive cancer cells in a simple new approach

Reducing sodium in common foods could prevent heart disease and stroke

Minimally invasive biopsy enables real-time tracking of amyloid disease progression

Genetic study reveals immune-related roots of allergic conjunctivitis

Lifetime alcohol consumption associated with higher risk of colorectal cancer

Olive oil type matters for cognition and gut health in older adults

Why exercise is essential for restoring fitness after GLP-1-based weight loss

Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease

Three daily servings of full-fat dairy do not worsen weight or blood markers

New role for GLP-1 drugs: Improving survival in people with severe psychiatric disorders

Evidence links gut microbiome changes to Alzheimer’s progression

Why the age you start smoking matters as much as how much you smoke

Diagnostic prognostic and therapeutic relevance of PIVKA-II in hepatocellular carcinoma

Colorblindness linked to delayed bladder cancer detection and higher mortality

Selective inhibition of cPLA2 shows promise against Alzheimer's-related brain inflammation

Large multi-ancestry study expands understanding of schizophrenia genetics

PTPN2 gene protects the gut from harmful bacteria driving inflammatory bowel disease

Orphan noncoding RNAs define cancer identity and enable blood-based monitoring

Unraveling liver injury mechanisms in familial hypobetalipoproteinemia

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

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