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Why individual differences hold the key to unlocking psychiatric mysteries

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Noritaka Ichinohe challenges a foundational assumption that has quietly constrained psychiatric research for decades: the belief that meaningful explanation requires averaging away individual differences.

6 Jan 2026

Using contrast-enhanced ultrasound to distinguish hepatic PEComa from HCC without high-risk factors

Announcing a new article publication for BIO Integration journal. Hepatic perivascular epithelioid cell tumor (PEComa) is a rare tumor with malignant potential that is frequently misdiagnosed as hepatocellular carcinoma (HCC), despite requiring distinct treatment approaches.

6 Jan 2026

Two isoforms of a cellular energy sensor play distinct, opposing roles in Alzheimer's disease

A comprehensive mini-review published today after peer review in Brain Medicine by Dr. Tao Ma and colleagues at Wake Forest University School of Medicine synthesizes emerging evidence that two isoforms of a critical cellular energy sensor play distinct, and sometimes opposing, roles in Alzheimer's disease.

6 Jan 2026

AI model can predict a person's disease risk using sleep data

A poor night's sleep portends a bleary-eyed next day, but it could also hint at diseases that will strike years down the road.

6 Jan 2026

New exercise-sensing pathway offers hope for osteoporosis treatment

A research team from the Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine at the University of Hong Kong (HKUMed) has uncovered a key biological mechanism that explains how exercise maintain strong bones, paving the way for novel treatments for osteoporosis and bone loss in people who are unable to engage.

6 Jan 2026

Repurposed drug combination shows strong promise against liver fibrosis

The study shows that this drug pair works far better together than either agent alone, offering a realistic and potentially fast path toward a new antifibrotic therapy.

6 Jan 2026

Nicotinic acid protects the liver from ischemia-reperfusion injury

In a new study published in Liver Research, a team of researchers in China discovered that nicotinic acid-a common form of vitamin B3-can dramatically reduce liver damage caused by ischemia-reperfusion injury (IRI), a major complication in liver surgery and transplantation.

5 Jan 2026

Can ketogenic diets help PCOS? New analysis points to weight and insulin gains

A systematic review and meta-analysis of 15 studies found that ketogenic diets were associated with short-term reductions in body weight, waist circumference, insulin resistance, and some reproductive hormones in women with polycystic ovary syndrome, primarily among those with overweight or obesity. However, substantial heterogeneity, low certainty of evidence, limited safety reporting, and short follow-up periods mean the clinical effectiveness and long-term sustainability of ketogenic diets in PCOS remain uncertain.

5 Jan 2026

Vitamin A derivative suppresses immune response and cancer vaccine efficacy

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response and, in a different context, the efficacy of a promising type of cancer vaccine.

5 Jan 2026

Jumping genes reshape cancer genomes through 3D chromatin interactions

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.

5 Jan 2026

Finger-prick blood tests enable remote detection of Alzheimer’s biomarkers

A groundbreaking international study has demonstrated that Alzheimer's disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to laboratories without refrigeration or prior processing.

5 Jan 2026

Diabetes could drain up to INT$78.8 trillion from the global economy by 2050, study finds

This global macroeconomic analysis estimates that diabetes mellitus will cost the world economy INT$10.2 trillion between 2020 and 2050, rising to INT$78.8 trillion when unpaid informal caregiving is included. Using a health-augmented economic model across 204 countries, the study shows that informal care is the dominant and most underestimated driver of diabetes-related economic losses worldwide.

5 Jan 2026

New guidelines aim to standardize diagnosis of canine dementia

An international working group of canine cognition experts has released a set of guidelines for veterinarians to use in diagnosing and monitoring canine cognitive dysfunction syndrome (CCDS), or canine dementia.

5 Jan 2026

Muscle loss may persist after weight recovery in anorexia nervosa

Anorexia nervosa is a psychiatric condition characterized by a fear of weight gain and reduced calorie consumption that can result in dangerous weight loss.

5 Jan 2026

Common blood signals explain why chronic diseases cluster as we age

This population-based study shows that shared and pattern-specific blood biomarkers reflect biological vulnerability underlying multimorbidity and the pace at which chronic diseases accumulate in older adults. Metabolic and systemic stress markers such as GDF15, HbA1c, cystatin C, and insulin consistently tracked higher disease burden and faster accumulation, with findings replicated across cohorts.

5 Jan 2026