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Combined physical frailty and depression may sharply raise dementia risk

Concurrent physical frailty and depression likely boost the risk of dementia in older people, with the interaction of these 2 factors alone contributing around 17% of the overall risk, suggest the findings of a large international study, published in the open access journal General Psychiatry.

16 Dec 2025

Specific gut bacterium reduces weight gain and improves metabolic health

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

16 Dec 2025

Alcohol-related liver disease deaths surge with widening socioeconomic gaps

Researchers at Saint Louis University School of Medicine say deaths from alcohol-related liver disease have surged in recent years, and the increase is hitting people without a college degree the hardest.

16 Dec 2025

Opposing protein forces fine tune mRNA stability in human cells

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders - including cancers, neurodegenerative diseases and immune disorders - originate, as well as how to potentially treat them, according to researchers at Penn State.

16 Dec 2025

Blocking a key cell pathway reduces muscle wasting in pancreatic cancer

Researchers at the University of Houston are pushing the boundaries of biomedical innovation with a discovery that could transform treatment for one of cancer's most devastating complications.

16 Dec 2025

New diagnostic chip enables rapid monitoring of brain cancer treatment

New diagnostic chip pulls packets released from tumor cells out of blood, showing whether cancer cells died during chemotherapy infusion.

16 Dec 2025

New rapid blood test enables early and accurate diagnosis of ALS

ALS is a debilitating paralytic disease characterized by the death of upper and lower motor neurons. Fortunately, ALS is relatively rare, with an incidence rate of 1.6 per 100,000 adults, resulting in about 30,000 cases in the United States at any one time.

16 Dec 2025

Targeted mRNA vaccines train the immune system to destroy cancer cells

No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation - which have undesirable side effects - what if we could train our own immune systems to kill the rogue cells?

16 Dec 2025

MEA-driven graph modeling identifies early connectivity changes linked to autism

Multi-electrode arrays (MEAs) provide a noninvasive interface with sub-millisecond temporal resolution and long-term, multi-site recordings, enabling mechanistic investigations of in vitro human brain development and disease-related dysfunction; nevertheless, conventional MEA pipelines largely rely on firing/burst statistics or channel-/waveform-level features, which can be insufficient to systematically characterize and interpret network-level organization and its subtle pathological deviations.

16 Dec 2025

AI enables rapid detection of coronary microvascular dysfunction from standard EKGs

Doctors may soon be able to diagnose an elusive form of heart disease within seconds by using an AI model developed at University of Michigan, according to a recent study.

16 Dec 2025

Traumatic brain injury disrupts brain drainage and accelerates Alzheimer’s risk

University of Virginia School of Medicine researchers have uncovered how and why traumatic brain injury (TBI) increases the risk for Alzheimer's disease, and their work suggests a potential way to prevent that increased risk.

16 Dec 2025

Pathology AI models show demographic bias in cancer diagnosis

Pathology has long been the cornerstone of cancer diagnosis and treatment. A pathologist carefully examines an ultrathin slice of human tissue under a microscope for clues that indicate the presence, type, and stage of cancer.

16 Dec 2025

A multi-gene mouse model reveals new mechanisms of Hirschsprung disease

During development of the digestive system, a complex network of nerves forms around it, creating a "second brain" - the enteric nervous system (ENS) - which controls the movement of food and waste through the gut.

16 Dec 2025

Global leaders adopt political declaration to combat NCDs and mental health challenges

Leaders from across the world at the Eightieth United Nations General Assembly (UNGA) have adopted the political declaration to combat noncommunicable diseases (NCDs) and mental health challenges through a fully integrated approach.

16 Dec 2025

Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment

A revolutionary quantum sensing project that could transform cancer treatment by tracking how immune cells interact with tumors has been awarded a prestigious £2 million Future Leaders Fellowship.

16 Dec 2025

Frog-derived bacteria offer dual-action anticancer effects and high safety

A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes.

16 Dec 2025

Bifunctional biomaterials for postoperative management of osteosarcoma

Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. The current standard treatment involves a combination of chemotherapy and radical surgical resection.

16 Dec 2025

Novel cryo-EM findings could revolutionize T cell immunotherapy design

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack dangerous cells. Yet a full understanding of how they actually work has eluded researchers.

16 Dec 2025

Relationship quality impacts heart health, study shows

With heart disease as the leading cause of death worldwide, there is growing recognition that recovery is not only physical but also emotional and social. A new study shows that strong and supportive relationships can indeed improve heart health for individuals with cardiovascular disease.

16 Dec 2025

First-of-its-kind mRNA system switches on therapeutic genes inside targeted cells

Researchers at the Icahn School of Medicine at Mount Sinai have developed a first-of-its-kind mRNA system that switches on therapeutic genes preferentially inside targeted cells-an advance demonstrated in studies in mice that could lay the groundwork for safer, more precise treatments for cancer and other diseases.

16 Dec 2025