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AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through changes in protein expression.

2 Dec 2025

Untreated restless legs syndrome may increase Parkinson's disease risk

Restless legs syndrome (RLS) is a common neurological sleep disorder characterized by an uncontrollable urge to move the legs, often worsening at night.

2 Dec 2025

Alzheimer's disease blood biomarkers increase up to 95% faster in obese individuals

Researchers have conducted the first study evaluating the impact of obesity on Alzheimer's disease blood biomarkers (BBMs).

2 Dec 2025

Study provides new hope for future treatment of intestinal condition IBS

Researchers at örebro University in Sweden have made a significant advance in understanding the intestinal condition IBS.

2 Dec 2025

Specific DNA sequences control spinal cord injury response

After a spinal cord injury, cells in the brain and spinal cord change to cope with stress and repair tissue. A new study from Karolinska Institutet, published in Nature Neuroscience, shows that this response is controlled by specific DNA sequences.

2 Dec 2025

WHO releases first guideline on the use of GLP-1 therapies for treating obesity

To address the growing global health challenge of obesity, which affects more than 1 billion people, the World Health Organization (WHO) has released its first guideline on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity as a chronic, relapsing disease.

2 Dec 2025

They need a ventilator to stay alive. Getting one can be a nightmare.

On vacation in Mexico last year, Michael DiPlacido passed out twice while scuba diving and again in his hotel. Back in St. Louis, doctors diagnosed him with amyotrophic lateral sclerosis, or ALS, an incurable disease that often requires mechanical ventilation.

2 Dec 2025

Unique stressors impact mental health of sexual minority individuals

A new study conducted by scientists at Åbo Akademi University, Finland, shows that sexual minority individuals continue to report higher levels of mental health symptoms compared to the rest of the population.

2 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Long COVID patients face more than double the healthcare costs after diagnosis

People with Long COVID use the health service significantly more than they did before their diagnosis. These patients need to use GP, outpatient, inpatient and emergency department services more than people in other control groups - and the costs of their healthcare use have more than doubled.

1 Dec 2025

Researchers receive NPB grant to develop online food allergy support tool

A team led by Aston University's Professor Rebecca Knibb in the School of Psychology has been awarded a grant by the US National Peanut Board (NPB) to develop an online food allergy support tool.

1 Dec 2025

Walking speed before hip replacement predicts long-term recovery success

Total hip arthroplasty (hip replacement) is a common treatment for hip osteoarthritis, a degenerative joint disease caused by cartilage in the hip joint wearing down.

1 Dec 2025

Study links endocrine-disrupting chemicals to hidradenitis suppurativa

A Johns Hopkins Medicine study involving a dozen people with the inflammatory skin disease hidradenitis suppurativa (HS), which mostly affects skin folds, is believed to be the first to provide evidence that hormone-disrupting chemicals commonly found in ultra-processed food and single-use water bottles may contribute to the development of or worsen the condition in some people.

1 Dec 2025

Researchers uncover GFAP’s role in mitochondrial dysfunction

Some brain disorders are straightforward, such as the direct frontal lobe assault of a concussion or traumatic brain injury. Others, like Alexander disease, are akin to guerilla warfare.

1 Dec 2025

New evidence supports ablation for high-risk patients with AFib and sleep apnea

Obstructive sleep apnea and atrial fibrillation are two conditions that share a potentially deadly link. Having one increases the odds of developing the other, and together, the breathing difficulties of sleep apnea combined with the irregular heartbeat of atrial fibrillation (AFib) can result in life-threatening cardiovascular risks.

1 Dec 2025

Epstein family support accelerates USC’s mission to end Alzheimer’s

The USC Alzheimer's Therapeutic Research Institute will be renamed the USC Epstein Family Alzheimer's Therapeutic Research Institute in honor of Life Trustee Daniel J. Epstein '62, his wife Phyllis and their family, who have been the philanthropic leaders behind the university's world-leading efforts to make Alzheimer's a memory.

1 Dec 2025

Rethinking community spaces and their impact on youth mental health

Parks, libraries, recreation centers, and sidewalks, ideally, would serve to improve the quality of living for residents, but it is not that simple, especially for youth. Research by Melissa Villodas, whose work focuses on understanding how social determinants of health impact the mental health of vulnerable young people, reveals that the relationship between neighborhood amenities and youth mental health is much more complex.

1 Dec 2025