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Biopsies of donated kidneys may not be useful for assessing organ quality prior to transplantation

A new study indicates that biopsies of donated kidneys are likely not useful for assessing organ quality prior to transplantation unless standards are set for how they should be performed and interpreted. The findings appear in an upcoming issue of CJASN.

24 Jan 2020

RB1 alterations in cancer cells may lead to treatment resistance

The Cancer Genetics Group of the Josep Carreras Leukaemia Research Institute, led by Montse Sánchez-Céspedes, together with Luis Montuenga from CIMA, and Enriqueta Felip from Vall d'Hebron Hospital, has revealed that inactivation of RB1 through intragenic rearrangements is frequent in lung cancer cells from non-smoking patients with EGFR mutations.

24 Jan 2020

Structural features of donated kidneys may influence their longevity in recipients

New research indicates that subtle structural features of donated kidneys from living donors may predict the risk of kidney transplant failure in recipients.

24 Jan 2020

Study: Weighted vests can help maintain bone density in older adults with obesity

Losing weight can be a tricky balance of risks and benefits for older adults: You want to shed fat to improve overall health, but preserve muscle and bone, which reduces risk of future injury.

23 Jan 2020

People with acquired paralysis later in life report higher rates of depression, anxiety

People with facial paralysis are more likely to face depression and anxiety than the general population, especially if the paralysis occurs later in life rather than at birth, according to a recent study from Oregon State University.

23 Jan 2020

Healing and hope for families affected by fragile X in Eastern Europe

Mothers and fathers and their young children crowded into an old, government-run children's hospital in Belgrade, Serbia, colorful, cartoonish drawings covering its hallway walls. Parents struggled to soothe their anxious, wriggly boys and girls. But they were patient, polite. It was, after all, a day unlike any other. A day for hope.

23 Jan 2020

Diabetes-related proteins seen in high-res for the first time

A team of researchers have reported, in an exciting study published in the journal Nature Communications, that they were able to examine an important receptor at high definition for the first time. This detailed visualization has helped them greatly to understand its mechanism of functioning. This could help develop better ways to treat Type 2 diabetes mellitus as well as other conditions.

23 Jan 2020

Researchers identify liver fibrosis ‘off switch’ in mice

Chronic alcohol abuse and hepatitis can injure the liver, often leading to a buildup of collagen and scar tissue.

23 Jan 2020

Lung microbes could help predict outcomes in the seriously ill

A new study published in the American Journal of Respiratory and Critical Care Medicine shows that recording the way the organisms living within the lungs change in type and numbers could reflect the response of the critically ill patient to medical care. Though changes in the lung microbiome have been known to exist even before this study, this research shows the clinical importance of this test.

23 Jan 2020

Living near major roads linked to higher incidence of neurological disorders

Living near major roads or highways is linked to higher incidence of dementia, Parkinson's disease, Alzheimer's disease and multiple sclerosis (MS), suggests new research published this week in the journal Environmental Health.

23 Jan 2020

Fetal surgery for spina bifida makes a huge difference 10 years later

A new study published in the journal Pediatrics shows that children with spina bifida, a congenital spinal disorder, who had corrective surgery in the womb, show significantly more benefit than those whose operations were performed after birth, even a decade later. These children have more of a chance to walk by themselves and a lower risk of needing more surgeries, compared to those whose condition is corrected only after birth.

23 Jan 2020

Long-term air pollution makes rhinitis symptoms worse

A new study published in the Journal of Allergy and Clinical Immunology reports that people exposed to polluted air out of doors show more severe symptoms of rhinitis, a very common condition also called a cold. This is due to an inflammation of the nasal mucosa.

23 Jan 2020

Being exposed to diesel exhaust particles raises pneumococcal disease risk

Air pollution is a long-standing global problem, which is responsible for 7 million deaths each year, with 7 percent of these attributed to pneumonia. A new study highlights how air pollution affects the airways making the body susceptible to developing the pneumococcal disease.

23 Jan 2020

Scientists discover small molecule that may slow or stop Parkinson's progression

A collaboration between scientists at Rutgers University and The Scripps Research Institute led to the discovery of a small molecule that may slow down or stop the progression of Parkinson's disease.

23 Jan 2020

Older refugees more likely to suffer from depression even decades after immigration

Most research on the mental health of refugees focuses on the first few years after resettlement in the host country, but little is known about their long-term mental health.

23 Jan 2020

Landmark study identifies 102 genes associated with autism risk

In the largest genetic sequencing study of autism spectrum disorder (ASD) to date, researchers have identified 102 genes associated with risk for autism. The study also shows significant progress towards teasing apart the genes associated with ASD from those associated with intellectual disability and developmental delay, conditions which often overlap.

23 Jan 2020

Novel drug can simultaneously help diagnose, treat gastric cancer

A novel drug, named "FerriIridium", can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is possible because of the higher amount of iron present there, report scientists in the journal Angewandte Chemie.

23 Jan 2020