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Low discontinuation rates confirm manageable safety of iza-bren

An investigational EGFR x HER3 antibody-drug conjugate demonstrated promising efficacy with a tolerable safety profile in patients with previously treated EGFR-mutated non-small cell lung cancer (NSCLC), supporting selection of the 2.5 mg/kg dose for evaluation in the global Phase 3 IZABRIGHT-Lung01 registrational study.

12 Sep 2026

Tumor DNA clearance reaches 39% in novel immunomodulator and ADC combination

The investigational combination of pumitamig and elfetabart drozuntecan (elfe-D) demonstrated a manageable safety profile and encouraging early antitumor activity in patients with small cell lung cancer (SCLC), according to first clinical data from the ongoing Phase 1b/2 BNT324-01 trial presented at the International Association for the Study of Lung Cancer (IASLC) 2026 World Conference on Lung Cancer (WCLC).

12 Sep 2026

Stricter glucose control may affect quality of life in people living with diabetes

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) shows that, in people living with diabetes (type 1 or 2) using data from continuous glucose monitoring (CGM) devices paired with daily quality-of-life ratings, days with more widely fluctuating glucose readings (while still within safe limits) are followed by days with a better quality life compared to days with more stricter control– suggesting the burden of that stricter control could be preventing those individuals with stricter control from enjoying various activities.

11 Sep 2026

Distinct EFEMP1 variants cause different forms of vision loss

Scientists identified a new vision condition linked to a gene already connected to a different vision-loss disease. While the previously identified disease causes loss of central vision, the new condition affects peripheral and night vision.

11 Sep 2026

FDA clears trial of dual-targeted CAR T-cell therapy for cancer

The U.S. Food and Drug Administration this week granted permission for investigators at the University of Colorado Anschutz to conduct a clinical trial testing genetically engineered immune cells in adults with advanced colorectal cancer and pediatric patients with solid cancers who have exhausted standard treatment options.

11 Sep 2026

Video game offers new insights into autistic perception

People with autism often come at life from a different angle-seeing details others miss, focusing on patterns rather than faces, experiencing heightened or dimmed physical sensations.

11 Sep 2026

Targeted nanoparticles strengthen anti-cancer immune responses in tumors

Adelaide University researchers have developed a new way of using mRNA technology to reprogram tumor-supporting immune cells and strengthen the body's anti-cancer immune response.

11 Sep 2026

Obesity suppresses natural protection against breast cancer growth

A research team at Huntsman Cancer Institute at the University of Utah (the U) has found that obesity prevents a biological process that kills cancerous cells, revealing a possible reason why obesity is a risk factor for breast cancer.

11 Sep 2026

Lupus-linked genetic variants may boost antiviral immunity

Why do genetic variants that increase the risk of autoimmune disease remain so common in the population?

11 Sep 2026

Giant-nucleus cells form the foundation of early-stage cancer

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous.

11 Sep 2026

Finnish study finds working from home increases sedentary behavior

According to a Finnish study, people sleep slightly longer when they work from home. However, they also sit more and are less physically active than on days when they work in the office.

11 Sep 2026

Early treatment significantly reduces joint damage in rheumatoid arthritis

Early and consistently managed treatment can have a decisive impact on the course of rheumatoid arthritis and prevent permanent joint damage.

11 Sep 2026

Neighborhood environments impact long-term health of 9/11 responders

Twenty-five years after the September 11 terrorist attacks, researchers at the Icahn School of Medicine at Mount Sinai have found that environmental conditions where World Trade Center responders live may influence their long-term physical and mental health.

11 Sep 2026

Cancer treatments alter the landscape of genetic mutations in healthy body tissues

Cancer treatments, including chemotherapy and radiotherapy, give a growth advantage to cells with particular genetic changes in healthy tissue, new research finds.

11 Sep 2026

McMaster researchers discover molecular switch causing dangerous blood clots

A cross-campus team of McMaster University researchers has identified why some patients develop dangerous blood clots after exposure to a common blood thinner – and a potential way to prevent it.

11 Sep 2026

AI identifies hidden biological patterns to accurately diagnose migraines

AI can trawl vast amounts of health data which is not specifically related to migraines, but which can be used to identify people predisposed to the condition.

11 Sep 2026

Early studies hint that ketones may affect pathways linked to PTSD

An integrative review found that ketogenic therapy may influence metabolic, inflammatory, oxidative stress, and neurotransmitter pathways implicated in PTSD, with animal studies and small human studies reporting early signs of symptom improvement. Human evidence remains limited to very small cohorts, case reports, and pilot studies, and controlled trials have yet to establish clinical efficacy.

11 Sep 2026

People with ADHD face higher odds of gastrointestinal problems

University of Warwick researchers have analyzed data from over 1.9 million people across 23 studies and found that ADHD is linked to an almost 50% increase in overall gastrointestinal symptoms compared with people without ADHD The association was even stronger for specific problems: nearly double the odds of constipation, a 58% increase in irritable bowel syndrome, and more than four times the odds of encopresis (loss of bowel control).

10 Sep 2026

Laser therapy offers new hope for inoperable pancreatic tumors

UCI Health, the clinical enterprise of the University of California, Irvine, is conducting a first-in-human, phase 1 clinical trial using laser light to target localized but inoperable pancreatic tumors to help patients become cancer free.

10 Sep 2026

Coffee after colorectal cancer? Decaf and caffeine show different links with mortality

In a prospective analysis of 1,098 people with colorectal cancer, researchers found no significant association between total or caffeinated coffee intake and all-cause or colorectal cancer-specific mortality in the cohort overall. Decaffeinated coffee was associated with lower all-cause mortality, while the highest quartile of caffeine intake was associated with lower all-cause and colorectal cancer-specific mortality, although the observational study cannot establish causation.

10 Sep 2026