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Unique strain of probiotic bacteria shows potential in combating inflammatory diseases

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.

23 Aug 2024

New treatment for rectal cancer offers hope in avoiding surgery

A new treatment for locally advanced rectal cancer shows favorable results in that surgery can sometimes be avoided completely.

23 Aug 2024

Understanding the health benefits of polyphenols through bitter taste receptors

Bioactive compounds like polyphenols and their health benefits have long captured public attention and interest.

23 Aug 2024

AI advances drug discovery for mental health disorders with new receptor models

Artificial intelligence (AI) can help identify molecules that could serve as new drugs for mental health disorders.

23 Aug 2024

Defective ZNRF3 gene causes opposing brain sizes and potential tumor risk

A gene called ZNRF3, known to be involved in cancer, also messes with the mind. The human brain relies on two copies of this gene to build a right-sized brain. If one of the copies is defective, the brain will be either too small or too large - known as mirror effect -, leading to various neurological symptoms.

23 Aug 2024

Advances in endoscopic treatment for inflammatory bowel disease complications

Inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions affecting the gastrointestinal tract.

23 Aug 2024

Study reveals bidirectional relationship between diabetes complications and mental health disorders

Heart attack, stroke, nerve damage. These are just some of the complications for which millions of Americans with diabetes are at greater risk.

23 Aug 2024

Innovative drug reduces inflammation in rats by inhibiting neutrophil activation

A newly developed compound that reduces harmful inflammation in rats caused by overactive neutrophils shows great potential as a safer treatment for various inflammatory diseases in humans.

23 Aug 2024

AmoyDx® Pan Lung Cancer PCR Panel approved in Japan as a companion diagnostic for Haiyitan® tablets (gumarontinib)

Riken Genesis Co., Ltd., Amoy Diagnostics Co., Ltd., and Precision Medicine Asia Co., Ltd. today announced that the Japanese Ministry of Health, Labour and Welfare has approved the AmoyDx® Pan Lung Cancer PCR Panel

From Amoy Diagnostics 23 Aug 2024

Cytek® Biosciences automates panel design with new intelligent algorithm

With the SpectroPanel tool, Cytek Cloud transforms flow cytometry panel design, enabling rapid optimization and enhancing research capabilities for scientists.

From Cytek Biosciences 23 Aug 2024

Maternal gut bacteria linked to changes in fetal brain metabolism

The impact of Bifidobacterium breve's presence in the maternal gut during pregnancy on fetal brain metabolism.

23 Aug 2024

Cognitive behavioral therapy enhances the mental well-being and life quality of cancer patients

The impact of cognitive-behavioral treatment on the mental health and quality of life of cancer patients.

23 Aug 2024

Risankizumab outperforms ustekinumab in treating moderate-to-severe Crohn’s disease

Researchers compare the therapeutic efficacy of risakizumab and ustekinumab for the treatment of moderate-to-severe Crohn’s disease.

23 Aug 2024

Maternal smoking increases risk of severe neonatal morbidity, even at low intensity

Researchers explore the association between severe neonatal morbidity and maternal smoking before or during pregnancy.

23 Aug 2024

Multimodal therapy shows promise for cancer treatment

Cancer remains one of the most challenging diseases to treat due to its complexity and tendency to metastasize (spread into or invade, nearby tissues or distant places in the body to form new tumors). Traditional therapies, such as chemotherapy and radiation, often face limitations like non-specific targeting and severe side effects. In response, researchers are turning to innovative approaches that combine multiple therapeutic modalities to address these issues. This study explores a cutting-edge solution involving CNHs to create a multimodal cancer phototheranostic platform integrating photothermal therapy (PTT), immunotherapy, and chemotherapy.

23 Aug 2024

New analytical method for identifying cancer cell targets

What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies. Scientists from the German Cancer Research Center (DKFZ) and the NCT Heidelberg are publishing a highly sensitive method based on mass spectroscopy to identify such tumor-specific "neoepitopes". The analytical method is designed to detect these low-abundance protein fragments and requires minimal amounts of sample material.

23 Aug 2024

Novel screening method for blood-brain barrier penetration

Scientists at Southwest Research Institute have developed a new screening method to identify drug formulations that can penetrate the blood-brain barrier (BBB), to facilitate treatment of brain diseases and conditions.

23 Aug 2024

Olaparib effective against BRCA2-mutated prostate cancer

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.

23 Aug 2024

FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

23 Aug 2024