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New discovery reveals how mutant RAS genes drive tumor growth

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.

11 Nov 2024

Targeted degradation of Pin1 shows promise for pancreatic cancer treatment

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins.

11 Nov 2024

Frailty increases a person's risk of dementia, study finds

An international study led by a University of Queensland researcher has found frailty increases a person's risk of dementia, but early intervention may be the key to prevention.

11 Nov 2024

Researchers develop new antibody with potential to treat several types of cancer

Researchers at Uppsala University and KTH Royal Institute of Technology have developed a new form of precision medicine, an antibody, with the potential to treat several types of cancer.

11 Nov 2024

VANCE trial marks milestone in t cell therapy for solid tumors

The largest ever clinical trial of T cell therapy for solid tumors has ended, heralding a new era for precision T cell therapy.

11 Nov 2024

Bystander CPR within 10 minutes of cardiac arrest increases survival chances and brain recovery

The sooner a lay rescuer (bystander) starts cardiopulmonary resuscitation (CPR) on a person having a cardiac arrest at home or in public, up to 10 minutes after the arrest, the better the chances of saving the person's life and protecting their brain function, according to preliminary research to be presented at the American Heart Association's Resuscitation Science Symposium 2024.

11 Nov 2024

Obesity-related heart disease deaths rise sharply in the U.S. between 1999 and 2020

Heart disease deaths related to obesity increased by 180% in the U.S. between 1999 and 2020, especially among middle-aged men, Black adults, residents of Midwestern states and non-metropolitan areas, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

COVID-19 pandemic led to significant decline in cardiac arrest survival rates

Out-of-hospital cardiac arrest survival rates dropped significantly at the onset of the COVID-19 pandemic in 2020 and have continued to remain lower than in the pre-pandemic years of 2015-2019, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

AI-based video system may offer quick, no-contact screenings for high blood pressure and diabetes

A new system that combines high-speed video and an artificial intelligence (AI)-powered algorithm may offer quick, no-contact screenings for high blood pressure and Type 1 or Type 2 diabetes without needing blood tests, blood pressure cuffs or expensive wearable devices, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

Just five minutes of activity a day could reduce blood pressure

Modest daily exercise, as little as five minutes, is linked to lower blood pressure, with significant benefits from longer activity durations.

11 Nov 2024

GLP-1 and SGLT2 inhibitors show promise in preventing recurrent stroke and heart attack

GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss, may reduce the risk of heart attack, second strokes and death in adults who had an initial stroke, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

Beta blockers linked to increased depression in heart attack patients

All patients who have had a heart attack are typically treated using beta blockers. According to a Swedish study conducted earlier this year, this drug is unlikely to be needed for those heart patients who have a normal pumping ability.

11 Nov 2024

911 telecommunicators improve CPR access for women during cardiac arrest

Women were less likely than men to receive cardiopulmonary resuscitation (CPR) in public, however, this disparity improved when 911 telecommunicators provided lifesaving instructions to callers seeking help for someone having a cardiac arrest, according to preliminary research to be presented at the American Heart Association's Resuscitation Science Symposium 2024.

11 Nov 2024

MESA heart disease risk score performs well even without race modifiers

A version of the MESA heart disease risk score that did not include race predicted heart disease risk just as well as the version that includes race, according to a preliminary study presented today at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

CKM syndrome leads to elevated cardiovascular disease risk earlier in life

People with chronic kidney disease, Type 2 diabetes or both were predicted to have elevated cardiovascular disease (CVD) risk 8 to 28 years sooner than someone without those conditions, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024

Redlining and its lasting impact on heart disease and diabetes

Heart disease, Type 2 diabetes, high blood pressure and obesity were more common and linked to reduced access to healthy foods among people who live in neighborhoods previously subjected to redlining, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024