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tAI could predict sensitivity to chemotherapy in patients with triple-negative breast cancer

Scientists have uncovered a marker of DNA damage that could predict who will respond to platinum-based chemotherapy drugs like cisplatin or carboplatin.

23 Mar 2012

Study provides important clue in type 1 diabetes

In type 1 diabetes (T1D), pancreatic beta cells die from a misguided autoimmune attack, but how and why that happens is still unclear. Now, JDRF-funded scientists from the Indiana University School of Medicine have found that a specific type of cellular stress takes place in pancreatic beta cells before the onset of T1D, and that this stress response in the beta cell may in fact help ignite the autoimmune attack.

23 Mar 2012

PFKFB4 gene leads to excessive growth of prostate cancer cells

Cancer cell metabolism may present a new target for therapy as scientists have uncovered a possible gene that leads to greater growth of prostate cancer cells.

23 Mar 2012

Verapamil drug may reverse diabetes-related death of pancreatic beta cells

A common high-blood-pressure medication appears to reverse the diabetes-related death of pancreatic beta cells, according to a University of Alabama at Birmingham study published today in the journal Diabetes.

23 Mar 2012

Study identifies abnormal brain gene expression patterns in autism

A study led by Eric Courchesne, PhD, director of the Autism Center of Excellence at the University of California, San Diego School of Medicine has, for the first time, identified in young autism patients genetic mechanisms involved in abnormal early brain development and overgrowth that occurs in the disorder. The findings suggest novel genetic and molecular targets that could lead to discoveries of new prevention strategies and treatment for the disorder.

23 Mar 2012

Researcher examines factors that influence injury rate among soccer players

All soccer players and fans know that it is better to win than to lose. Yet the fact that victory also means less risk of injury is not as obvious. New findings from researchers in sports medicine at Linköping University have aroused great interest among Europe's elite soccer teams.

23 Mar 2012

Hyperion acquires worldwide rights to Ucyclyd's Ravicti

Hyperion Therapeutics, Inc. today announced that it has acquired worldwide rights to the investigational drug Ravicti from Ucyclyd Pharma, Inc., a wholly owned subsidiary of Medicis Pharmaceutical Corporation.

23 Mar 2012

No added benefit from retigabine therapy in adults with epileptic seizures

The drug retigabine was approved in March 2011 as add-on therapy for adults with epileptic seizures. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether retigabine offers an added benefit compared with the present standard therapy.

23 Mar 2012

WCI technique uses MRS to detect oncometabolites

Researchers at Winship Cancer Institute have developed a technique for detecting an "oncometabolite", a chemical produced by some brain tumors' warped metabolism, via non-invasive imaging.

23 Mar 2012

Towards a more comprehensive view of brain-hand relationship

Research at Arizona State University and Columbia University to better understand the intricate sensory and cognitive connections between the brain and the hands has won support from the National Science Foundation. New discoveries about such connections could benefit people with neurological disorders such as Parkinson's disease and cerebral palsy, and those who need prosthetic hands.

22 Mar 2012

A rare forum on stem cell biology, engineering and clinical translation

On March 23, during the 41st Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 36th Annual Meeting of the Canadian Association for Dental Research, a symposium titled "TMJ: Stem Cell Biology and Engineering toward Clinical Translation" will provide a rare forum for multidisciplinary discussion of the biology, engineering and clinical translation of fundamental discoveries towards novel clinical therapy.

22 Mar 2012

EACP recommends minimum standards for emergency cardiovascular care at stadiums

Cardiac arrest during professional sports activities has occurred in the past. Unfortunately, this has not led to a general improvement of the situation in Europe. The recent case of British football player Fabrice Muamba is, regretfully, a sad reminder of the need to adhere to existing guidelines for the screening of athletes and for the safety in big gatherings, especially (but not only) in professional sports events.

22 Mar 2012

Reading Arabic is more challenging to the brain

Readers whose mother tongue is Arabic have more challenges reading in Arabic than native Hebrew or English speakers have reading their native languages, because the two halves of the brain divide the labor differently when the brain processes Arabic than when it processes Hebrew or English.

22 Mar 2012

Study uses Veridex CellSearch technology to capture CECs in MI patients

Veridex, LLC today announced the publication of a new, investigational study published this week in Science Translational Medicine that lays the foundation for research that may potentially result in a blood test to determine imminent risk of heart attack within high-risk populations.

22 Mar 2012

Study identifies ROS in the gaseous phase of cigarette smoke

A team of researchers led by A. K. Rajasekaran, PhD, Director of the Nemours Center for Childhood Cancer Research, has shown that a key protein involved in cell function and regulation is stopped by a substance present in cigarette smoke.

22 Mar 2012

CINJ clinical trials leader receives 2012 Award of Excellence from HOPA

Susan Goodin, PharmD, FCCP, BCOP, associate director of clinical trials and therapeutics at The Cancer Institute of New Jersey (CINJ) has received the 2012 Award of Excellence from the Hematology/Oncology Pharmacy Association.

22 Mar 2012

Antidepressants can play a key role in relieving pain associated with OA

Antidepressants can play a key role in alleviating painful conditions like osteoarthritis and may result in fewer side effects than traditionally prescribed drug regimes, such as anti-inflammatories and opioids, according to a perspective paper published online ahead of print publication by the International Journal of Clinical Practice.

22 Mar 2012

AACR to honor PU professor with Award for Outstanding Achievement in Cancer Research

A researcher from The Cancer Institute of New Jersey (CINJ) and Princeton University who is helping to advance the molecular understanding of cancer metastasis is being recognized for his work by cancer specialists from around the globe.

22 Mar 2012

Allen Institute for Brain Science receives $300M gift to expand scientific programs

The Allen Institute for Brain Science announced today that, given its achievements to date, Paul G. Allen has committed an additional $300 million to the Institute to significantly expand its scientific programs.

22 Mar 2012

State roundup: Oregon's coordinated care program moves ahead

Ten thousand more employees at five city agencies have signed on to Mayor Rahm Emanuel's plan to raise monthly health insurance premiums by $50 for employees who fail to participate in a "wellness program" to manage chronic health problems. Emanuel hopes to save $20 million in 2012 -- and $240 million over four years -- by riding herd over costly, but controllable problems like diabetes, high blood pressure, heart disease and asthma.

22 Mar 2012