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Oral Eliquis receives FDA approval for treatment of clots in non-valvular atrial fibrillation patients

The U.S. Food and Drug Administration today approved the anti-clotting drug Eliquis (apixaban), an oral tablet used to reduce the risk of stroke and dangerous blood clots (systemic embolism) in patients with atrial fibrillation that is not caused by a heart valve problem.

29 Dec 2012

Study reveals modest association between presence of tumor boards and types of cancer care

There is little association of multidisciplinary tumor boards with measures of use, quality, or survival, and measuring only the presence of tumor boards may not be adequate in determining their effects on cancer care, according to a study published December 28 in the Journal of the National Cancer Institute.

29 Dec 2012

Early problems in processing knowledge-based information linked to Alzheimer's disease

People who study or treat Alzheimer's disease and its earliest clinical stage, mild cognitive impairment (MCI), have focused attention on the obvious short-term memory problems. But a new study suggests that people on the road to Alzheimer's may actually have problems early on in processing semantic or knowledge-based information, which could have much broader implications for how patients function in their lives.

29 Dec 2012

Clinical approach to swallowing of foreign bodies

It is a well known fact that children often swallow things. Children aged 6 months to 6 years are most often affected, but even adults sometimes end up with a foreign body stuck in their throats-and not only there.

29 Dec 2012

Aeterna Zentaris reaches SPA agreement with FDA for AEZS-108 Phase 3 trial in endometrial cancer

Aeterna Zentaris Inc. today announced that it has reached an agreement with the U.S. Food and Drug Administration ("FDA") on a Special Protocol Assessment ("SPA") for an upcoming Phase 3 registration trial in endometrial cancer with its doxorubicin peptide conjugate, AEZS-108. The SPA agreement states that the proposed trial protocol design, clinical endpoints and planned analyses are acceptable to the FDA to support a regulatory submission.

29 Dec 2012

Behavioral changes and discipline needed to lose weight

Losing weight and saving money are perenially the top New Year's resolutions made by many Americans. But both require behavioral changes and a certain amount of discipline.

29 Dec 2012

Heart transplant patient becomes unexpected ambassador for organ donation

Kevin Riepl arrived at Cedars-Sinai in October 2010, suffering from sudden heart failure that left him fighting for his life. Surgeons swiftly installed a heart pump and later transplanted a new heart, saving his life and turning him into an unexpected ambassador for organ donation.

29 Dec 2012

Scientists identify molecular mechanism central to development of osteoarthritis pain

Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could have major implications for future treatment of this often-debilitating condition.

28 Dec 2012

New light on how epigenetic signals may function together to determine fate of stem cell

Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

28 Dec 2012

Group health approved for PCORI research awards to study care for back pain

Group Health has been approved for two research awards from the Patient-Centered Outcomes Research Institute (PCORI) to study ways to improve care for back pain and to connect patients with community resources. The projects are part of a portfolio of patient-centered comparative clinical effectiveness research that addresses PCORI's National Priorities for Research and Research Agenda.

28 Dec 2012

Key regulator of energy metabolism in cancer cells may play a crucial role in restricting cancer cell growth

Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; AMPK is turned on when it senses changes in energy levels, and helps to change metabolism when energy levels are low, such as during exercise or when fasting.

28 Dec 2012

Bariatric surgery succeeds when new year resolutions to lose weight fail

For years Blanca Ramirez, like many Americans, started each new year with a resolution to lose weight. But no more. "I lost 55 pounds this year and the weight is rolling off and will stay off," said the 42 year-old, married, mother of three. Ramirez underwent bariatric surgery at Loyola Center for Metabolic Surgery & Bariatric Care in August and has lost 55 pounds in four months.

28 Dec 2012

Novel approach to sort out good or bad mutations associated with lymphoma

As anyone familiar with the X-Men knows, mutants can be either very good or very bad - or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set them apart from other cells in the body; the scientific challenge has been to figure out which mutations are culprits and which are innocent bystanders.

28 Dec 2012

Immune-promoting drugs may control recurrent disease

Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease.

28 Dec 2012

Researchers develop unique approach to calpain inhibition

Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in muscular dystrophy, AIDS, Alzheimer's disease, multiple sclerosis, and cancer. As such, finding and exploiting calpain inhibitors is an important area of research.

28 Dec 2012

Scientists develop two novel model systems for human corneal endothelium

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants.

28 Dec 2012

New cost-effective, less invasive MRI method for diagnosis of dementia

A new way to use MRI scans may help determine whether dementia is Alzheimer's disease or another type of dementia, according to new research published in the December 26, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.

27 Dec 2012

Trovagene adds Duke University Health System to worldwide licensees of NPM1 marker for AML

Trovagene, Inc., a developer of transrenal molecular diagnostics, announced it has granted Duke University and Duke University Health Systems a non-exclusive license to incorporate nucleophosmin protein (NPM1) into research and clinical testing services for acute myelogenous leukemia (AML).

27 Dec 2012

Researchers reveal critical role of BRCA1 gene in maintenance of hair follicle stem cells

Our DNA, which stores our genetic information, is constantly submitted to damage. If not properly repaired, DNA damage can lead to cell death, which may in turn lead to tissue exhaustion and ageing, or induce mutations resulting in uncontrolled cell proliferation and cancer. Brca1 is a key gene that mediates DNA repair. Mutations in Brca1 lead to familial and sporadic breast and ovarian cancer in humans.

27 Dec 2012

Study reveals decline in cancer screening rates

The rate of people who seek preventive cancer screenings has fallen over the last ten years in the United States with wide variations between white-collar and blue-collar workers, according to a University of Miami Miller School of Medicine study published on December 27 in the open-access journal Frontiers in Cancer Epidemiology.

27 Dec 2012

Medical Condition News

Oral Eliquis receives FDA approval for treatment of clots in non-valvular atrial fibrillation patients

Study reveals modest association between presence of tumor boards and types of cancer care

Early problems in processing knowledge-based information linked to Alzheimer's disease

Clinical approach to swallowing of foreign bodies

Aeterna Zentaris reaches SPA agreement with FDA for AEZS-108 Phase 3 trial in endometrial cancer

Behavioral changes and discipline needed to lose weight

Heart transplant patient becomes unexpected ambassador for organ donation

Scientists identify molecular mechanism central to development of osteoarthritis pain

New light on how epigenetic signals may function together to determine fate of stem cell

Group health approved for PCORI research awards to study care for back pain

Key regulator of energy metabolism in cancer cells may play a crucial role in restricting cancer cell growth

Bariatric surgery succeeds when new year resolutions to lose weight fail

Novel approach to sort out good or bad mutations associated with lymphoma

Immune-promoting drugs may control recurrent disease

Researchers develop unique approach to calpain inhibition

Scientists develop two novel model systems for human corneal endothelium

New cost-effective, less invasive MRI method for diagnosis of dementia

Trovagene adds Duke University Health System to worldwide licensees of NPM1 marker for AML

Researchers reveal critical role of BRCA1 gene in maintenance of hair follicle stem cells

Study reveals decline in cancer screening rates

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

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