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Protein complex plays critical role in development of Alzheimer's disease

The Bonn site of the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn are leading contributors.

21 Dec 2012

OncoMed commences dosing in OMP-52M51 Phase 1 clinical trial for hematologic cancers

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today announced that patient dosing has begun in a Phase 1 clinical trial of OMP-52M51 in patients with hematologic cancers.

21 Dec 2012

Cubist seeks FDA sNDA approval for ENTEREG to accelerate GI recovery

Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) today announced that it has submitted a supplemental new drug application (sNDA) to the U.S. Food and Drug Administration (FDA) requesting approval for the use of ENTEREG® (alvimopan) to accelerate GI recovery following any surgery that includes a bowel resection with primary anastomosis; expanded from the current indication in patients requiring surgery for colorectal disease.

21 Dec 2012

Molecule imitating a virus may trigger inappropriate immune response

Why would our immune system turn against our own cells? This is the question that the combined Inserm/CNRS/ Pierre and Marie Curie University/Association Institut de Myologie have strived to answer in their "Therapies for diseases of striated muscle", concentrating in particular on the auto-immune disease known as myasthenia gravis.

21 Dec 2012

PCPs agree they may not be the best health care professionals to give weight related counseling

Your primary care physician may be your first choice for assistance with most health-related issues, but according a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health, primary care physicians agree they may not be the best health care professionals to give weight related counseling.

21 Dec 2012

Researchers create first ever atlas of immune cells in the human body

By analyzing tissues harvested from organ donors, Columbia University Medical Center (CUMC) researchers have created the first ever "atlas" of immune cells in the human body.

21 Dec 2012

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

A researcher with the Faculty of Medicine & Dentistry and the Mazankowski Alberta Heart Institute is looking closely at a molecule linked to aortic aneurysms in the abdomen, and her findings could lead to a treatment to reduce swelling of the aortic artery, which would be a life-saving treatment.

21 Dec 2012

Real estate businessman delivers $2.5M gift to University of Chicago Medicine for GI study

Real estate businessman Seymour "Sy" Taxman and his wife, Nancy, presented a gift of $2.5 million to the University of Chicago Medicine on Wednesday in honor of the late Joseph B. Kirsner, MD, PhD, the Louis Block Distinguished Service Professor of Medicine and a pioneer in the research and treatment of digestive disease.

21 Dec 2012

Study finds increased risk of cancers among rescue/recovery workers after WTC terrorist attack

Among rescue and recovery workers exposed to the dust, debris, and fumes following the World Trade Center terrorist attack, there was an increased incidence of prostate and thyroid cancers and multiple myeloma, although it is not clear how big a factor medical screening and non-WTC risk factors contributed to these increases, according to a study in the December 19 issue of JAMA.

21 Dec 2012

Iron oxide nanoparticles could help track transplanted human endothelial cells

A team of researchers from three medical institutions in Guangzhou, China, have found that iron oxide nanoparticles (INOPS) are a useful contrast agent for in vivo magnetic resonance tracking of transplanted human endothelial cells.

21 Dec 2012

Surgeons make thousands of errors every year

So-called 'never events' happen more than 4,000 times a year, according to a study by Johns Hopkins researchers. Another report finds health care workers just as likely as people they treat to be overweight, avoid the dentist, get sunburned and not wear seatbelts.

21 Dec 2012

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.

21 Dec 2012

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

My mortality wake-up call came in a hospital after knee surgery, when I flat-lined because of a heart arrhythmia and was resuscitated by a nurse. In response to columns about those events, stories have streamed in from people who are running out of time themselves, or enduring the pain of watching loved ones fade. The deaths they face are as different as the lives they've lived, but a steady refrain runs through their emails and letters.

21 Dec 2012

New MRI scans accurately measure damage to blood-brain barrier in stroke victims

Johns Hopkins researchers have developed a new way of looking at standard MRI scans that more accurately measures damage to the blood-brain barrier in stroke victims, a process they hope will lead to safer, more individualized treatment of blood clots in the brain and better outcomes.

21 Dec 2012

Updated U.S. prescribing information for Boehringer Ingelheim’s Pradaxa

Boehringer Ingelheim Pharmaceuticals, Inc. today announced that the U.S. prescribing information for Pradaxa (dabigatran etexilate mesylate) capsules was updated to include a contraindication related to use in patients with mechanical prosthetic heart valve replacement.

21 Dec 2012

Researchers reveal genetic basis for fundamental differences between humans and other vertebrates

University of Toronto Faculty of Medicine researchers have uncovered a genetic basis for fundamental differences between humans and other vertebrates that could also help explain why humans are susceptible to diseases not found in other species.

21 Dec 2012

NFKB gene variations could play a key role in helping to determine survival rate of sepsis patients

A study in the January 2013 issue of Anesthesiology offers evidence that variations in what is called the NFKB gene could play an important role in helping to determine the survival rate of patients who acquire sepsis, a condition in which the body is overwhelmed by infection, and which is the leading cause of death in hospitals.

21 Dec 2012

Addiction specialists co-edit new textbook to help Canadians stop smoking

Researchers from the University of Alberta are helping Canadian smokers butt out with a new textbook designed to give health professionals the right tools to treat tobacco addiction.

21 Dec 2012

Study examines role of race and ethnicity in stem cell donation

New research examining the role of race and ethnicity in an individual's decision to become a donor for hematopoietic cell transplantation (HCT) identifies several factors associated with varied participation rates in national donor registries across racial/ethnic groups. Results of this first-of-its-kind study are published online today in Blood, the Journal of the American Society of Hematology (ASH).

21 Dec 2012

Melanoma patients may benefit from microRNA-26a replacement therapy

A University of Colorado Cancer Center study in this month's edition of the Journal of Investigative Dermatology describes a new target and potential treatment for melanoma, the most dangerous form of skin cancer. MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent.

21 Dec 2012

Medical Condition News

Protein complex plays critical role in development of Alzheimer's disease

OncoMed commences dosing in OMP-52M51 Phase 1 clinical trial for hematologic cancers

Cubist seeks FDA sNDA approval for ENTEREG to accelerate GI recovery

Molecule imitating a virus may trigger inappropriate immune response

PCPs agree they may not be the best health care professionals to give weight related counseling

Researchers create first ever atlas of immune cells in the human body

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

Real estate businessman delivers $2.5M gift to University of Chicago Medicine for GI study

Study finds increased risk of cancers among rescue/recovery workers after WTC terrorist attack

Iron oxide nanoparticles could help track transplanted human endothelial cells

Surgeons make thousands of errors every year

Study shows how to prod stem cells to become 2 different types of blood vessel tissues

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

New MRI scans accurately measure damage to blood-brain barrier in stroke victims

Updated U.S. prescribing information for Boehringer Ingelheim’s Pradaxa

Researchers reveal genetic basis for fundamental differences between humans and other vertebrates

NFKB gene variations could play a key role in helping to determine survival rate of sepsis patients

Addiction specialists co-edit new textbook to help Canadians stop smoking

Study examines role of race and ethnicity in stem cell donation

Melanoma patients may benefit from microRNA-26a replacement therapy

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

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