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Amgen to pay $762 million fine for improper drug marketing

Biotech giant Amgen Inc. pleaded guilty in federal court to improper marketing of its anemia drug Aranesp and has agreed to pay $762 million in criminal fines and civil settlements to resolve complaints from company whistle-blowers. Federal prosecutors in New York said the Thousand Oaks company was "pursuing profits at the risk of patient safety" by encouraging doctors to use its popular anemia drug for unapproved uses to boost sales and to take market share from a rival drug maker.

20 Dec 2012

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) - and, in the process, have uncovered a possible therapeutic target as a novel strategy to treat both disorders.

20 Dec 2012

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

By all accounts, a combination of colon cancer, diabetes and high blood pressure can be a recipe for medical disaster. Now, a new study led by a surgical oncologist and researcher at Temple University School of Medicine and Fox Chase Cancer Center has shown just how deadly this mix can be.

20 Dec 2012

New clues in understanding how epithelial cells repair themselves following chlorine-related injury

Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

20 Dec 2012

GI bacteria exert some control over their hosts' appetites: Review

Over the last half decade, it has become increasingly clear that the normal gastrointestinal (GI) bacteria play a variety of very important roles in the biology of human and animals. Now Vic Norris of the University of Rouen, France, and coauthors propose yet another role for GI bacteria: that they exert some control over their hosts' appetites.

20 Dec 2012

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

As many as 50 percent of all human protein-coding genes are regulated by microRNA (miRNA) molecules. While some miRNAs impact onset and progression of cancer, others can actually suppress the development of malignant tumors and are useful in cancer therapy. They can also serve as potential biomarkers for early cancer detection. In a new issue of Cancer Biomarkers, investigators report on non-coding miRNAs as appealing biomarkers for malignancy.

20 Dec 2012

Hospitals with good work environment have low readmission rates

New research from the University of Pennsylvania School of Nursing has found that Medicare patients treated in hospitals with a good work environment for nurses had up to ten percent lower odds of readmission than those treated in hospitals with a poor work environment.

20 Dec 2012

Positive top-line results from Idera’s IMO-3100 Phase 2a trial on plaque psoriasis

Idera Pharmaceuticals today announced that 48% of patients with moderate-to-severe plaque psoriasis (12 of 25) treated with IMO-3100, a selective antagonist of Toll-like Receptors (TLRs) 7 and 9, demonstrated improvements in Psoriasis Area Severity Index (PASI) scores of 35% to 90% from baseline at the completion of a randomized, double-blind, placebo-controlled Phase 2a clinical trial of two dose levels of IMO-3100 administered for four weeks, with a four-week follow-up period.

20 Dec 2012

New therapeutic ultrasound approach could lead to an invisible knife for noninvasive surgery

A carbon-nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.

20 Dec 2012

Link made between muscular dystrophy and defective nerve wiring

Working with mice, Johns Hopkins scientists have discovered that a particular protein helps nerve cells extend themselves along the spinal cord during mammalian development. Their results shed light on the subset of muscular dystrophies that result from mutations in the gene that holds the code for the protein, called dystroglycan, and also show how the nerve and muscle failings of the degenerative diseases are related.

20 Dec 2012

Household rules can help parents resolve conflicts and guard children's mental health

Holiday presents will soon be under the tree for millions of adolescents. With those gifts may come sibling squabbles over violations of personal space, such as unwanted borrowing of a fashionable clothing item, or arguments over fairness, such as whose turn it is to play a new video game. Those squabbles represent two specific types of sibling conflict that can have different effects on a youth's emotional health, according to a multi-year study by a University of Missouri psychologist.

20 Dec 2012

Study helps reveal how nervous system modulates motor control patterns

Most people are impressed by how a toad jumps. UC Irvine biologist Emanuel Azizi is more impressed by how one lands. An assistant professor of ecology & evolutionary biology who specializes in muscle physiology and biomechanics, Azizi found that nature's favorite leapers possess a neuromuscular response that's specific to the intensity of a landing - a mechanism that protects muscles from injury upon impact.

20 Dec 2012

Researchers reveal role of dendritic cells in Type 1 diabetes

The researchers reveal the role of the innate immune cells, especially the dendritic cells, that cause the activation of the killer T-lymphocytes whose action is directed against the p pancreatic cells. The results obtained in mice make it possible to consider new ways of regulating the auto-immune reaction generated by the innate immune cells.

20 Dec 2012

Seattle Times examines partnership between Hutchinson Cancer Research Center, Uganda Cancer Institute

The Seattle Times examines a partnership between the Fred Hutchinson Cancer Research Center and the Uganda Cancer Institute (UCI). In 2008, "the two institutes formally agreed to collaborate on clinical care and research projects, and more recently a major building project at Uganda's only cancer-research center," the newspaper writes.

20 Dec 2012

Lou Gehrig's disease may be treatable using neural stem cells

Promising new research provides evidence that ALS, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be treatable using neural stem cells.

20 Dec 2012

Investigators assess efficacy of ORC vs. robotic-assisted laparoscopic radical cystectomy

About 30 percent of the more than 70,000 bladder cancer cases expected in 2012 are muscle invasive. In such cases, radical cystectomy is the preferred treatment. In a pilot trial, a team of investigators assessed the efficacy of open radical cystectomy (ORC) vs. robotic-assisted laparoscopic radical cystectomy (RARC).

20 Dec 2012

Few alcohol-related story ideas from The Methodist Hospital

The holidays are a time to consume -- food, gifts, and spirits. Here are a few alcohol-related story ideas from The Methodist Hospital. Because alcohol's effects on human physiology are complex, advice about is often contradictory.

20 Dec 2012

SR9238 compound can reverse effects of fatty liver disease

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed the first synthetic compound that can reverse the effects of a serious metabolic condition known as fatty liver disease. True to its name, the disease involves an abnormal buildup of fat in the liver.

20 Dec 2012

People with chronic shortness of breath may soon have new way to help alleviate their discomfort

People experiencing chronic shortness of breath may soon have a new way to help alleviate their discomfort, according to a Penn State College of Medicine pulmonology researcher.

20 Dec 2012

Researchers uncover mechanism that switches off cell transport regulating proteins

Researchers at the RUB and from the MPI Dortmund have uncovered the mechanism that switches off the cell transport regulating proteins. They were able to resolve in detail how the central switch protein Rab is down-regulated with two "protein fingers" by its interaction partners.

20 Dec 2012

Medical Condition News

Amgen to pay $762 million fine for improper drug marketing

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

New clues in understanding how epithelial cells repair themselves following chlorine-related injury

GI bacteria exert some control over their hosts' appetites: Review

Investigators report non-coding miRNAs as appealing biomarkers for cancer malignancy

Hospitals with good work environment have low readmission rates

Positive top-line results from Idera’s IMO-3100 Phase 2a trial on plaque psoriasis

New therapeutic ultrasound approach could lead to an invisible knife for noninvasive surgery

Link made between muscular dystrophy and defective nerve wiring

Household rules can help parents resolve conflicts and guard children's mental health

Study helps reveal how nervous system modulates motor control patterns

Researchers reveal role of dendritic cells in Type 1 diabetes

Seattle Times examines partnership between Hutchinson Cancer Research Center, Uganda Cancer Institute

Lou Gehrig's disease may be treatable using neural stem cells

Investigators assess efficacy of ORC vs. robotic-assisted laparoscopic radical cystectomy

Few alcohol-related story ideas from The Methodist Hospital

SR9238 compound can reverse effects of fatty liver disease

People with chronic shortness of breath may soon have new way to help alleviate their discomfort

Researchers uncover mechanism that switches off cell transport regulating proteins

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

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