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Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Researchers at Western University have made a breakthrough that could lead to a better understanding of a common form of arthritis that, until now, has eluded scientists.

4 Dec 2012

Certain SSRI medications fail to achieve same selectivity for prevention of SUDEP

Scientists from Southern Illinois University today reported the results of a study evaluating the potential effect of two selective serotonin reuptake inhibitors (SSRI) antidepressant medications in reducing the risk of sudden unexpected death in epilepsy (SUDEP).

4 Dec 2012

Researchers discover 15 new genetic regions linked with coronary artery disease

The University of Ottawa Heart Institute (UOHI) participated in the largest genetic study of Coronary Artery Disease (CAD) to date. Researchers from the CARDIoGRAMplusC4D Consortium report the identification of 15 genetic regions newly associated with the disease, bringing to 46 the number of regions associated with CAD risk.

3 Dec 2012

Enzalutamide shows promise in treating triple-negative and estrogen-positive breast cancer

Breast cancers are defined by their drivers - estrogen and progesterone receptors (ER and PR) and HER2 are the most common, and there are drugs targeting each. When breast cancer has an unknown driver, it also has fewer treatment options - this aggressive form of breast cancer without ER, PR or HER2, which was thought not to be driven by hormones, is known as triple negative.

3 Dec 2012

Prrx1 component prevents cancer cells from lodging in other organs

Researchers discover that the cellular component Prrx1 prevents cancer cells from lodging in other organs and, therefore, generating new focuses of cancer.

3 Dec 2012

Scientists discover new target molecule for development of treatment against Alzheimer's

Scientists from VIB and KU Leuven have discovered a new target molecule for the development of a treatment against Alzheimer's disease. There is currently no cure for this disease.

3 Dec 2012

Obstructive sleep apnea affects women more severely than men

Women suffering from sleep apnea have, on the whole, a higher degree of brain damage than men with the disorder, according to a first-of-its-kind study conducted by researchers at the UCLA School of Nursing.

3 Dec 2012

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Merck, known as MSD outside the United States and Canada, announced it has started a Phase II/III clinical trial designed to evaluate the safety and efficacy of MK-8931 versus placebo in patients with mild-to-moderate Alzheimer's disease.

3 Dec 2012

Diabetes tests: an interview with Dr. Danielle Stowasser

Diabetes is a serious condition that causes high levels of glucose (a type of sugar) in the blood. There are three main types of diabetes: type 1 and type 2 diabetes, which are lifelong conditions, and gestational diabetes, which only occurs in women during pregnancy.

3 Dec 2012

Researchers identify new genetic regions associated with heart attacks

In the largest genetic study of Coronary Artery Disease (CAD) to date, researchers from the CARDIoGRAMplusC4D Consortium report the identification of 15 genetic regions newly associated with the disease, bringing to 46 the number of regions associated with CAD risk.

3 Dec 2012

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charité - Universitätsmedizin Berlin and the Université Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

3 Dec 2012

Specific transporters could be exploited to deliver toxic substances into cancer cells

Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, the overexpression of specific transporters could be exploited to deliver toxic substances into cancer cells.

3 Dec 2012

NeuroVive announce results from CicloMulsion Phase I trial on cardiac reperfusion injury

NeuroVive announces publication of the results of a Phase I clinical trial of lead product CicloMulsion in the scientific journal Clinical Drug Investigation. The paper highlights that the intravenous cyclosporine formulation CicloMulsion demonstrates bioequivalence and improved tolerability when compared with Sandimmune Injection.

3 Dec 2012

GORE EXCLUDER AAA Endoprosthesis receives CE Mark

W. L. Gore & Associates, Inc. (Gore) has received CE Mark for the new large diameter 35 mm trunk-ipsilateral leg and 36 mm aortic extender components of the GORE EXCLUDER AAA Endoprosthesis.

3 Dec 2012

Heart attack centres: an interview with Dr Sayan Sen

Heart attack networks are designed to facilitate the rapid transfer of heart attack patients to centres with facilities that allow the manual unblocking of the coronary artery with angioplasty.

3 Dec 2012

Scientists identify 15 new genetic regions associated with coronary artery disease

Fifteen new genetic regions associated with coronary artery disease have been identified by a large, international consortium of scientists - including researchers at the Stanford University School of Medicine - taking a significant step forward in understanding the root causes of this deadly disease. The new research brings the total number of validated genetic links with heart disease discovered through genome-wide association studies to 46.

3 Dec 2012

New laser surgical technique appears to be safe and effective in treating epilepsy

A developing new laser surgical technique for epilepsy appears to be safe and effective and reduces hospital stays to one or two days, according to two research reports presented today during the American Epilepsy Society 66th Annual Meting at the San Diego Convention Center.

3 Dec 2012

Chronic focal brain cooling suppresses seizures during wakefulness

Neuroscientists from Japan's Yamaguchi University today reported during the 66th annual scientific meeting of the American Epilepsy Society (AES) that chronic focal brain cooling suppresses seizures during wakefulness and achieves the effect without significantly affecting brain function. Their research, and that of others in the field, provides critical evidence that this approach to seizure control has reached a stage where testing in humans will soon be possible.

3 Dec 2012

Long-term hippocampal DBS effectively reduces seizures in experimental models

The results of the first reported study of deep brain stimulation (DBS) in an animal model for temporal lobe epilepsy (TLE) presented today at the American Epilepsy Society (AES) 66th Annual Meeting suggests that DBS may have potential as therapy for this common and often difficult to treat form of epilepsy.

2 Dec 2012

TINCR molecule plays a master role in epidermal differentiation

The surface of your skin, called the epidermis, is a complex mixture of many different cell types - each with a very specific job. The production, or differentiation, of such a sophisticated tissue requires an immense amount of coordination at the cellular level, and glitches in the process can have disastrous consequences. Now, researchers at the Stanford University School of Medicine have identified a master regulator of this differentiation process.

2 Dec 2012

Medical Condition News

Researchers discover first-ever mouse model of diffuse idiopathic skeletal hyperostosis

Certain SSRI medications fail to achieve same selectivity for prevention of SUDEP

Researchers discover 15 new genetic regions linked with coronary artery disease

Enzalutamide shows promise in treating triple-negative and estrogen-positive breast cancer

Prrx1 component prevents cancer cells from lodging in other organs

Scientists discover new target molecule for development of treatment against Alzheimer's

Obstructive sleep apnea affects women more severely than men

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Diabetes tests: an interview with Dr. Danielle Stowasser

Researchers identify new genetic regions associated with heart attacks

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

Specific transporters could be exploited to deliver toxic substances into cancer cells

NeuroVive announce results from CicloMulsion Phase I trial on cardiac reperfusion injury

GORE EXCLUDER AAA Endoprosthesis receives CE Mark

Heart attack centres: an interview with Dr Sayan Sen

Scientists identify 15 new genetic regions associated with coronary artery disease

New laser surgical technique appears to be safe and effective in treating epilepsy

Chronic focal brain cooling suppresses seizures during wakefulness

Long-term hippocampal DBS effectively reduces seizures in experimental models

TINCR molecule plays a master role in epidermal differentiation

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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