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New CETP blockers continue to show promise as viable heart drugs

Mindful of lessons from a failed heart drug that cost $800 million to develop, drug companies are taking another shot at new medications that boost levels of so-called "good cholesterol," which removes cholesterol from the body.

23 Feb 2012

Surgery associated with brain atrophy in elderly patients with MCI

A study published in the March issue of Anesthesiology found that elderly patients with mild cognitive impairment (MCI), as well as normal elderly undergoing surgery experienced increased levels of brain atrophy beyond what is expected from normal aging.

23 Feb 2012

FDA, pharmaceutical companies announce solution to cancer drug shortage

The U.S. Food and Drug Administration and several pharmaceutical companies said Tuesday they have reached agreements to alleviate shortages for the drugs methotrexate and Doxil. Methotrexate is used to treat children with a form of leukemia and others with tumors of the breast and lungs. Doxil is used to treat ovarian cancer and multiple myeloma.

23 Feb 2012

AFA applauds nation's first National Alzheimer's Plan

The following is a statement by Eric J. Hall, president and CEO of the Alzheimer's Foundation of America (AFA), in response to the U.S. Department of Health and Human Services' release today of its "Draft National Plan To Address Alzheimer's Disease."

23 Feb 2012

Gonadal dysgenesis may also increase risk of gonadal tumors

Pediatric and Developmental Pathology - Gonadal dysgenesis—defective development of the ovaries or testes— may also bring with it an increased risk of gonadal tumors. A recent discovery at the histologic level could help identify cells at risk of conversion into a tumor.

23 Feb 2012

Intravenous ibuprofen: A key addition to perioperative pain management

Hendersonville Medical Center today announced that anesthesiologist Peter B. Kroll, M.D., has published an article in the January issue of peer-reviewed medical journal Pain Management.

23 Feb 2012

Environmental health risks low in the United Arab Emirates

By global standards, health risks caused by environmental factors are low in the United Arab Emirates (UAE), new studies by University of North Carolina at Chapel Hill researchers show.

23 Feb 2012

HHS releases first draft of National Alzheimer's Plan

The release of the first draft of the National Alzheimer's Plan is another positive step toward the nation's first ever strategic plan for Alzheimer's.

23 Feb 2012

AAOS calls for submission of stories of orthopaedic care

The American Academy of Orthopaedic Surgeons (AAOS) encourages patients of all ages to submit their stories of orthopaedic care at www.aNationinMotion.org

23 Feb 2012

Dual regulation by similar proteins may degenerate in heart failure

Sudden cardiac death is a risk for patients with heart failure because the calcium inside their heart cells is not properly controlled and this can lead to an irregular heartbeat. New findings published in PLoS ONE, which reveal mechanisms that underlie this life-threatening risk, provide new possibilities for fighting it.

23 Feb 2012

U-M Cardiovascular Center now offers Edwards aortic valve replacement

As the population ages, more Americans will be susceptible to aortic stenosis, but not all patients can tolerate surgery to treat it. Select U.S. hospitals are now performing minimally invasive procedures called transcatheter aortic valve replacement, or TAVR, to replace a patient's diseased aortic valve without heart bypass or open heart surgery.

From Medtronic 23 Feb 2012

DIRECT project to focus on stratification of patients with type 2 diabetes

Gathering experts from 21 European academic institutions and key players of the pharmaceutical industry, the DIRECT project (DIabetes REsearch for patient straTification) will focus on the stratification of patients with type 2 diabetes in order to develop personalized treatments, that would therefore be more efficient.

23 Feb 2012

Unknown facets of biological mechanism that immune cells use for creating free radicals

Sometimes our immune defence attacks our own cells. When this happens in the brain we see neurodegenerative diseases such as dementia, Alzheimer's and Parkinson's disease. But if the the immune defence is inhibited, the results could be disastrous.

23 Feb 2012

Elevated levels of two TLRs can trigger heart disease and diabetes

UC Davis scientists have uncovered a key suspect in the destructive inflammation that underlies heart disease and diabetes. The new research shows elevated levels of a receptor present on leucocytes of the innate immune response in people at risk for these chronic diseases.

23 Feb 2012

Assessing family medical history helps spot patients at high risk of heart disease

A new study by researchers at The University of Nottingham has proved that assessing family medical history is a significant tool in helping GPs spot patients at high risk of heart disease and its widespread use could save lives.

23 Feb 2012

Scientists design compounds that act against myotonic dystrophy type 1 RNA

While RNA is an appealing drug target, small molecules that can actually affect its function have rarely been found. But now scientists from the Florida campus of The Scripps Research Institute have for the first time designed a series of small molecules that act against an RNA defect directly responsible for the most common form of adult-onset muscular dystrophy.

23 Feb 2012

Varenicline improves walking ability in patients with SCA3

A nicotinic drug approved for smoking cessation significantly improved the walking ability of patients suffering from an inherited form of ataxia, reports a new clinical study led by University of South Florida researchers.

23 Feb 2012

Inven2, OGT enter license agreement for 12 colorectal cancer biomarkers

Oxford Gene Technology (OGT), provider of innovative clinical genetics and diagnostic solutions to advance molecular medicine, announced today that it has entered into an exclusive licensing agreement with Inven2, the technology transfer office at Oslo University Hospital (OUS) and University of Oslo (UiO), for 12 highly promising colorectal cancer tissue biomarkers.

From Oxford Gene Technology 23 Feb 2012

Vemurafenib nearly doubles survival for patients with metastatic melanoma

Investigators from Vanderbilt-Ingram Cancer Center (VICC) and 12 other centers in the United States and Australia have found that a new drug for patients with metastatic melanoma nearly doubled median overall survival.

23 Feb 2012

Actelion, Auxilium partner to develop and commercialize XIAFLEX

Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. announced today that they have entered into a long-term partnership for the development, supply and commercialization of XIAFLEX (collagenase clostridium histolyticum), a novel, first-in-class biologic for the potential treatment of Dupuytren's contracture and Peyronie's disease.

23 Feb 2012