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Studies examine how PML gene regulates the fatty acid oxidation pathway

Two papers led by scientific teams from the Cancer Genetics Program at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms underlying cellular energy and metabolism and, at the same time, highlight both the challenges and opportunities of genetic approaches to cancer treatment.

31 Aug 2012

Bayer submits regorafenib NDA with FDA for treatment of metastatic and/or unresectable GIST

Bayer HealthCare and Onyx Pharmaceuticals today announced that Bayer HealthCare has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the oral multi-kinase inhibitor regorafenib for the treatment of metastatic and/or unresectable gastrointestinal stromal tumors (GIST) in patients whose disease has progressed despite prior treatment.

31 Aug 2012

U.S. lags three other industrialized nations in potentially preventable death rates

The United States lags three other industrialized nations-France, Germany, and the United Kingdom-in its potentially preventable death rate, and in the pace of improvement in preventing deaths that could have been avoided with timely and effective health care, according to a Commonwealth Fund-supported study published as a web first online today in Health Affairs.

31 Aug 2012

Study explains how FPGS increases effectiveness of pemetrexed in mesothelioma patients

Previous studies have hypothesized that low levels of the enzyme thymidylate synthase (TS) likely mark patients who will benefit from the drug pemetrexed - but results have been inconclusive at best and at times contradictory. A University of Colorado Cancer Center study recently published in the Journal of Thoracic Oncology provides an explanation why: only in combination with high levels of a second enzyme, FPGS, does low TS predict response to pemetrexed in patients with malignant pleural mesothelioma.

31 Aug 2012

Researchers discover how tamoxifen-resistant breast-cancer cells grow and proliferate

A study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has discovered how tamoxifen-resistant breast-cancer cells grow and proliferate.

31 Aug 2012

Enrollment complete in Arrowhead’s CALAA-01 phase 1b trial on solid tumors

Arrowhead Research Corporation, a targeted therapeutics company, today announced that, through its Calando Pharmaceuticals subsidiary, it has completed enrollment of a phase 1b clinical trial of CALAA-01, its RNAi therapeutic candidate targeting solid tumors. All patients participating in the trial have completed dosing with the exception of one patient who is still receiving treatment and will continue to be monitored.

31 Aug 2012

Ironwood receives FDA approval for Linzess to treat chronic idiopathic constipation, IBS

The U.S. Food and Drug Administration today approved Linzess (linaclotide) to treat chronic idiopathic constipation and to treat irritable bowel syndrome with constipation (IBS-C) in adults.

31 Aug 2012

Grb10 plays a crucial role in increasing muscle mass during development

Scientists have moved closer toward helping people grow big, strong muscles without needing to hit the weight room. Australian researchers have found that by blocking the function of a protein called Grb10 while mice were in the womb, they were considerably stronger and more muscular than their normal counterparts.

31 Aug 2012

Sosei’s QVA149 Phase III study on COPD meets primary endpoint

Sosei Group Corporation confirms the information released today by Novartis that results from the fifth QVA149 (indacaterol maleate / glycopyrronium bromide) Phase III study, SPARK, met its primary endpoint of a reduced rate of moderate-to-severe COPD exacerbations compared to glycopyrronium bromide.

31 Aug 2012

Chronic nerve pain: an interview with Professor Sally Lawson

Chronic nerve pain results from pathological changes within a nerve that appear to be self-sustaining and thus the pain continues for a long time.

30 Aug 2012

Single serve packages may help reduce energy intake at breakfast

Mega-sized portions clearly have contributed to our nation's obesity problem, but it is not just the super-sized menu items that are a concern. Serving sizes at home have also crept up over recent decades, with plates and bowls much larger than the dishes used by our great-grandparents. Packaged foods that are available in portion packs might be an easy aid for reigning in portion sizes, but do they actually help us to eat fewer calories overall?

30 Aug 2012

Drug-resistant tuberculosis levels described as alarming by international study

A large, international study published Online First in The Lancet reveals alarming levels of tuberculosis (TB) that are resistant to both first-line and second-line drugs. The findings show high prevalence of resistance to at least one second-line drug (43.7%) among multidrug-resistant (MDR) TB patients from eight countries in Africa, Asia, Europe, and Latin America. Worse still, the study found higher than expected overall levels of extensively drug-resistant (XDR) TB.

30 Aug 2012

New book on medical screening to be launched on Sep. 4

Delegates from around the world will gather for the launch of a new book on medical screening edited by University of Leicester academics.

30 Aug 2012

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

Removing the entire pancreas in patients with cancer or precancerous cysts in part of the organ does not result in unmanageable diabetes — as many physicians previously believed, research at Mayo Clinic in Florida has found.

30 Aug 2012

Stowers investigators define factors that regulate size of cellular fat pools

As the national waistline expands, so do pools of intra-cellular fat known as lipid droplets. Although most of us wish our lipid droplets would vanish, they represent a cellular paradox: on the one hand droplets play beneficial roles by corralling fat into non-toxic organelles. On the other, oversized lipid droplets are associated with obesity and its associated health hazards.

30 Aug 2012

Residency cap may hamper efforts to expand number of doctors

Bloomberg examines the need for more primary care physicians and the limit on the number of slots for training doctors.

30 Aug 2012

UAB Center of Research Translation to improve health of patients with gout, hyperuricemia

The University of Alabama at Birmingham is establishing a Center of Research Translation to improve the health of an increasing number of patients with gout and hyperuricemia.

30 Aug 2012

New York State Department of Health issues license to Veracyte's Afirma Gene Expression Classifier

Veracyte, Inc., a molecular diagnostics company pioneering the emerging field of molecular cytology, and Genzyme, a Sanofi company, today announced that the New York State Department of Health has issued a license enabling Veracyte's Afirma Gene Expression Classifier to be offered to patients in the state.

30 Aug 2012

MU medicinal chemists create more potent, efficient weapon against cancer

Legend has it that Ralph Waldo Emerson once said, "Build a better mousetrap, and the world will beat a path to your door." University of Missouri researchers are doing just that, but instead of building mousetraps, the scientists are targeting cancer drugs. In a new study, MU medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer, added a special structure to it, and created a more potent, efficient weapon against cancer.

30 Aug 2012

EHRA White Book reports on current status of arrhythmia treatments in 54 ESC member countries

The analysis was conducted using five editions of the EHRA White Book, which is produced by the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC).

30 Aug 2012

Medical Condition News

Studies examine how PML gene regulates the fatty acid oxidation pathway

Bayer submits regorafenib NDA with FDA for treatment of metastatic and/or unresectable GIST

U.S. lags three other industrialized nations in potentially preventable death rates

Study explains how FPGS increases effectiveness of pemetrexed in mesothelioma patients

Researchers discover how tamoxifen-resistant breast-cancer cells grow and proliferate

Enrollment complete in Arrowhead’s CALAA-01 phase 1b trial on solid tumors

Ironwood receives FDA approval for Linzess to treat chronic idiopathic constipation, IBS

Grb10 plays a crucial role in increasing muscle mass during development

Sosei’s QVA149 Phase III study on COPD meets primary endpoint

Chronic nerve pain: an interview with Professor Sally Lawson

Single serve packages may help reduce energy intake at breakfast

Drug-resistant tuberculosis levels described as alarming by international study

New book on medical screening to be launched on Sep. 4

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

Stowers investigators define factors that regulate size of cellular fat pools

Residency cap may hamper efforts to expand number of doctors

UAB Center of Research Translation to improve health of patients with gout, hyperuricemia

New York State Department of Health issues license to Veracyte's Afirma Gene Expression Classifier

MU medicinal chemists create more potent, efficient weapon against cancer

EHRA White Book reports on current status of arrhythmia treatments in 54 ESC member countries

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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