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Repeated surgeries may improve survival for patients with glioblastomas

People who undergo repeated surgeries to remove glioblastomas - the most aggressive and deadliest type of brain tumors - may survive longer than those who have just a one-time operation, new Johns Hopkins research suggests.

2 Nov 2012

CD22 protein could prove to be important new target for anti-cancer therapy

A team of UC Davis investigators has discovered a protein on the surface of lung cancer cells that could prove to be an important new target for anti-cancer therapy. A series of experiments in mice with lung cancer showed that specific targeting of the protein with monoclonal antibodies reduced the size of tumors, lowered the occurrence of metastases and substantially lengthened survival time.

2 Nov 2012

New video-protocol details steps to generate human iPSCs from peripheral blood cells

Stem cells are a valuable resource for medical and biological research, but are difficult to study due to ethical and societal barriers. However, genetically manipulated cells from adults may provide a path to study stem cells that avoid any ethical concerns. A new video-protocol in JoVE (Journal of Visualized Experiments), details steps to generate human induced pluripotent stem cells (iPSC) from cells in the peripheral blood.

2 Nov 2012

XJB-5-131 compound suppresses symptoms of Huntington's in mice

There's new hope in the fight against Huntington's disease. A group of researchers that includes scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

2 Nov 2012

PET scans allow scientists to study link between caffeine and neurodegenerative disorders

Molecular imaging with positron emission tomography (PET) has enabled scientists for the first time to visualize binding sites of caffeine in the living human brain to explore possible positive and negative effects of caffeine consumption.

2 Nov 2012

Developing comorbid conditions post-liver transplant reduces donor quality of life

Researchers in Japan report that health-related quality of life (HRQOL) for donors following living donor liver transplantation (LDLT) was better than the general Japanese population (the norm). This study—one of the largest to date—found that donors who developed two or more medical problems (co-morbidities) after donation had significantly decreased long-term HRQOL.

2 Nov 2012

Lecture to examine how eating habits are influenced by physiology and psychology

The coming crisis for society caused by millions of people who are seriously overweight will be discussed at a University of Greenwich public lecture on 28 November.

2 Nov 2012

Australia's Generation X on the path to become more obese than baby boomers

New research from the University of Adelaide shows that Australia's Generation X is already on the path to becoming more obese than their baby boomer predecessors.

2 Nov 2012

Researchers unlock complex cellular mechanics that instruct glial progenitor cells to divide

In a new study appearing this month in the Journal of Neuroscience, researchers have unlocked the complex cellular mechanics that instruct specific brain cells to continue to divide. This discovery overcomes a significant technical hurdle to potential human stem cell therapies; ensuring that an abundant supply of cells is available to study and ultimately treat people with diseases.

2 Nov 2012

Takeda, Affymax announce data from OMONTYS Phase 3 studies on anemia due to CKD

Affymax, Inc. and Takeda Pharmaceuticals U.S.A., Inc. (TPUSA) today announced the presentation of post-hoc sub-group analyses of the EMERALD Phase 3 studies that evaluated OMONTYS (peginesatide) Injection, an erythropoiesis-stimulating agent (ESA), for the treatment of anemia due to chronic kidney disease (CKD) in adult dialysis patients.

2 Nov 2012

MH6 vaccine shows promise in treating meth addiction

Scientists at The Scripps Research Institute (TSRI) have performed successful tests of an experimental methamphetamine vaccine on rats. Vaccinated animals that received the drug were largely protected from typical signs of meth intoxication.

2 Nov 2012

Antipsychotic drugs associated with increased mortality among people with schizophrenia

Results of a Johns Hopkins study suggest that individuals with schizophrenia are significantly more likely to live longer if they take their antipsychotic drugs on schedule, avoid extremely high doses and also regularly see a mental health professional.

2 Nov 2012

Study describes role of TFIIB protein in helping cells repair DNA damage

In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.

2 Nov 2012

Insomnia and sleep apnoea turn us into major health service consumers

Insomnia and sleep apnoea are turning us into major health service consumers, causing us to be less productive at work, and may even lead to serious accidents.

2 Nov 2012

Study identifies monoacylglycerol lipase as new therapeutic target to treat Alzheimer's

Research led by Chu Chen, PhD, Associate Professor of Neuroscience at LSU Health Sciences Center New Orleans, has identified an enzyme called Monoacylglycerol lipase (MAGL) as a new therapeutic target to treat or prevent Alzheimer's disease.

2 Nov 2012

TransTech Pharma to complete TTP054 Phase 2 trial on type 2 diabetes

TransTech Pharma, Inc., announced today that recruitment of patients for its recently initiated, multi-center Phase 2 clinical trial of TTP054 in type 2 diabetics, is exceeding expectations with initial top line results available in early 2013. The 90-day proof of concept study is being conducted in type 2 diabetics not well controlled with approved oral anti-diabetic agents.

2 Nov 2012

Apolipoprotein E plays a major role in maintaining arterial softness

Arterial stiffening has long been considered a major risk factor for cardiovascular disease. Keeping arteries soft and supple might reduce disease risk, but the mechanisms of how arteries stave off hardening has remained elusive.

2 Nov 2012

Inotek announces final data from trabodenoson Phase 2 trial on PAOG or ocular hypertension

Inotek Pharmaceuticals Corp., a leader in the development of innovative drug candidates to address significant diseases of the eye, today announced that final data from a Phase 2 clinical trial of trabodenoson, also known as INO-8875, in patients with primary open-angle glaucoma or ocular hypertension will be presented at the Ophthalmology Innovation Summit on Thursday, November 8, 2012 at the Chicago Marriott Downtown Magnificent Mile in Chicago, IL.

2 Nov 2012

High blood cholesterol far more common than previously recognized

High blood cholesterol, a serious hereditary disease, is far more common than previously recognised and not treated sufficiently.

2 Nov 2012

NJH researchers discover novel target for treatment of food allergies

Researchers at National Jewish Health have discovered a novel target for the treatment of food allergies. Erwin Gelfand, MD, and his colleagues report in the October 2012 issue of the Journal of Allergy and Clinical Immunology that levels of the enzyme Pim 1 kinase rise in the small intestines of peanut-allergic mice. Inhibiting activity of Pim 1 markedly reduced the allergic response to peanuts.

2 Nov 2012

Medical Condition News

Repeated surgeries may improve survival for patients with glioblastomas

CD22 protein could prove to be important new target for anti-cancer therapy

New video-protocol details steps to generate human iPSCs from peripheral blood cells

XJB-5-131 compound suppresses symptoms of Huntington's in mice

PET scans allow scientists to study link between caffeine and neurodegenerative disorders

Developing comorbid conditions post-liver transplant reduces donor quality of life

Lecture to examine how eating habits are influenced by physiology and psychology

Australia's Generation X on the path to become more obese than baby boomers

Researchers unlock complex cellular mechanics that instruct glial progenitor cells to divide

Takeda, Affymax announce data from OMONTYS Phase 3 studies on anemia due to CKD

MH6 vaccine shows promise in treating meth addiction

Antipsychotic drugs associated with increased mortality among people with schizophrenia

Study describes role of TFIIB protein in helping cells repair DNA damage

Insomnia and sleep apnoea turn us into major health service consumers

Study identifies monoacylglycerol lipase as new therapeutic target to treat Alzheimer's

TransTech Pharma to complete TTP054 Phase 2 trial on type 2 diabetes

Apolipoprotein E plays a major role in maintaining arterial softness

Inotek announces final data from trabodenoson Phase 2 trial on PAOG or ocular hypertension

High blood cholesterol far more common than previously recognized

NJH researchers discover novel target for treatment of food allergies

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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