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Innovative dual-drug strategy for colorectal cancer treatment

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed.

27 Jul 2024

New biomarker helps determine the optimal treatment for colon cancer

Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn't improve the chances of survival for every patient. A study published July 25th, 2024 in Cell Reports Medicine identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy.

27 Jul 2024

New study highlights paternal influence on child's T1D risk

New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9-13 September) shows that a child is almost twice as likely to develop type 1 diabetes (T1D) if their father has the condition than if their mother has the condition.

27 Jul 2024

New guidelines expand BRCA testing and screening for men

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.

27 Jul 2024

Study finds stark differences in stroke center access by income

Low-income communities are up to 42% less likely to obtain stroke center certification.

27 Jul 2024

Moffitt study identifies predictive biomarkers for immunotherapy in merkel cell carcinoma

Merkel cell carcinoma is a rare but highly aggressive form of skin cancer known for its rapid growth and tendency to metastasize. Despite the promise of immune checkpoint blockade therapy, which can boost the body's immune response against cancer cells, nearly half of patients do not respond to this treatment.

26 Jul 2024

UCLA scientists awarded $300,000 grant to study glioblastoma microenvironment

Scientist Dr. Aparna Bhaduri, assistant professor of medicine and biological chemistry, and neurosurgeon Dr. Kunal Patel, assistant professor of neurosurgery, both part of the UCLA Health Jonsson Comprehensive Cancer Center, have received the 2024 Neurobiology of Brain Disorders Award from the McKnight Endowment Fund for Neuroscience, which supports innovative research by U.S. scientists who are studying neurological and psychiatric diseases.

26 Jul 2024

Anxiety’s Long-Term Impact on Dementia Development

The longitudinal relationship between chronic, resolved, and new onset anxiety and the risk of all-cause dementia (Progressive cognitive decline affecting memory and thinking).

26 Jul 2024

Machine learning models predict disability progression in multiple sclerosis

Machine learning models can reliably inform clinicians about the disability progression of multiple sclerosis, according to a new study published this week in the open-access journal PLOS Digital Health by Edward De Brouwer of KU Leuven, Belgium, and colleagues.

25 Jul 2024

Cordyceps sinensis shown to alleviate idiopathic pulmonary fibrosis in mice

A recent study from China has reported that Cordyceps sinensis (CS), a traditional Chinese medicinal fungus, can ameliorate idiopathic pulmonary fibrosis (IPF) in mice by inhibiting mitochondrion-mediated oxidative stress.

25 Jul 2024

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients, according to a new study by investigators at Weill Cornell Medicine, the University of Pennsylvania, and Medidata AI.

25 Jul 2024

Researchers identify a potential therapeutic target for advanced multiple sclerosis

Researchers from Kyushu University have identified a potential therapeutic target for the treatment of advanced multiple sclerosis (MS), a potentially disabling condition associated with the central nervous system.

25 Jul 2024

New review highlights advances in diabetes research and treatment

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

25 Jul 2024

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

UQ opens new facility for personalized mRNA cancer vaccine development

A new facility at The University of Queensland is set to provide Australian researchers with cancer vaccines tailored to individual patients.

25 Jul 2024

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

UK initiative aims to transform MND research through health data collaboration

MND is a devastating disease affecting the motor neurones in the brain and spinal cord, leading to progressive muscle weakness and paralysis.

25 Jul 2024

Can cutting back on extra virgin olive oil make your heart healthier?

Two levels of extra virgin olive oil intake in a plant-based diet both reduce LDL cholesterol, with lower intake showing a more significant effect.

25 Jul 2024

Research reveals Medicare's inadequate payments for lifesaving stroke procedures

Despite thrombectomy's high success rate in saving the lives of stroke patients, Medicare is paying lower rates over time for the procedure, according to research presented today at the Society of NeuroInterventional Surgery's (SNIS) 21st Annual Meeting.

25 Jul 2024

Posterior foraminotomy shows comparable results to anterior discectomy for cervical radiculopathy

For patients with cervical radiculopathy, posterior foraminotomy provides outcomes comparable to those of the more commonly performed anterior cervical discectomy, reports a randomized clinical trial in The Journal of Bone & Joint Surgery.

25 Jul 2024