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Unraveling gene regulation's role in pulmonary fibrosis

Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?

28 Mar 2024

AudioCure Pharma: Novel compound AC102 restores noise-induced hearing loss in preclinical models

A single application of the novel compound AC102 almost completely restores noise-induced hearing loss in preclinical models.

28 Mar 2024

Genetic and lifestyle factors linked to brain network aging, study reveals

Research highlights the impact of genetic and lifestyle factors on a brain network particularly sensitive to aging, schizophrenia, and Alzheimer's disease, using data from nearly 40,000 UK Biobank participants to investigate modifiable risk factors and genetic associations.

28 Mar 2024

Predicting treatment response in common blood cancer with DNA methylation profiling

A recent study led by Dr. Manel Esteller, Director of the Josep Carreras Institute, shows how DNA methylation profiling in a common type of blood cancer, myelodysplastic syndrome, predicts whether the patient will respond to treatment.

28 Mar 2024

Transformative epilepsy surgery gives artist new lease on life

Artist Syril Strickler was 47 when she had her first epileptic seizure, waking up in the hospital after neighbors found her unconscious in the street.

28 Mar 2024

New research advocates genetic screening in early onset atrial fibrillation

Although the vast majority of clinicians do not view atrial fibrillation (AF) as a genetic disorder, a White Paper in the Canadian Journal of Cardiology, published by Elsevier, analyzes the current understanding of genetics and the role of genetic testing in AF and concludes there is an increasing appreciation that genetic culprits for potentially life-threatening ventricular cardiomyopathies and channelopathies may initially present with AF.

28 Mar 2024

Early understanding of diabetes risk could help in better disease management

With diabetes increasing at an alarming rate in the United States, Diabetes Alert Day is meant to be a one-day "wake-up call" to the seriousness of diabetes and the importance of understanding your risk.

28 Mar 2024

Emergency departments prove fertile ground for smoking cessation success

The Cessation of Smoking Trial in the Emergency Department (COSTED) study demonstrates that a brief intervention including e-cigarette starter kits can significantly help smokers in emergency departments quit, offering a new avenue to tackle smoking rates and associated health inequalities.

28 Mar 2024

Clinical trial to test the feasibility of using at-home cancer immunotherapy

A clinical trial from Keck Medicine of USC will test the feasibility of treating non-small cell lung cancer with immunotherapy provided at home.

28 Mar 2024

Familial Alzheimer's transmissible through bone marrow transplants, study shows

Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show March 28 in the journal Stem Cell Reports.

28 Mar 2024

Researchers discover key drivers behind follicular lymphoma's aggressive transformation

A team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of blood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.

28 Mar 2024

Accredited hospitals demonstrate better outcomes for patients undergoing rectal cancer surgery

Hospitals accredited by the American College of Surgeons National Accreditation Program for Rectal Cancer demonstrate significantly better outcomes for patients undergoing rectal cancer surgery compared to non-accredited hospitals, according to a new study published in the Journal of the American College of Surgeons.

28 Mar 2024

Study finds changing trends in arterial disease risk among diabetics

There has been a redistribution in the risk of arterial disease in type 1 and 2 diabetes. The risks of heart attack and stroke have decreased significantly, while complications in more peripheral vessels have increased in relative importance, according to studies at the University of Gothenburg.

28 Mar 2024