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Stenting improves long term outcomes in CTO PCI patients

In patients undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI), stenting demonstrated improved long-term survival and fewer cardiac arrests at one year.

2 May 2025

Heat triggers sperm activation for fertilization in mammals

In mammals - including us humans - sperm are surprisingly picky about temperature, thriving best in conditions a few degrees cooler than normal body temperature.

2 May 2025

Early TAVR shows greatest stroke reduction in patients aged 65 to 70

New analysis from the EARLY TAVR trial showed patients between the age of 65 and 70 years old derived the most benefits of a strategy of early intervention with transcatheter aortic valve replacement (TAVR) compared to other age groups, especially in regards to stroke risk, and in regards to the composite of death, stroke, and heart failure hospitalization.

2 May 2025

HO-1 regulates liver fibrosis in NAFLD through the SIRT1 TGF-β Smad3 pathway

Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis.

2 May 2025

New albumin-based vaccine shows promise for mucosal immunity

Vaccines save millions of lives every year, but there is still an urgent need for more efficient vaccines. Strategies to combat serious outbreaks of viral infections are particularly important.

2 May 2025

Medicaid rollbacks could deepen health inequities

A new analysis provides evidence that reductions in access to Medicaid could increase deaths and cause financial hardship to people currently covered under an expansion of Medicaid that was implemented under the Affordable Care Act (ACA).

2 May 2025

New insights into facial bacteria may improve acne treatment strategies

The composition of bacterial populations living on our faces plays a significant role in the development of acne and other skin conditions such as eczema.

2 May 2025

Single antiplatelet therapy after TAVR linked to lower mortality and bleeding

Findings from the Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) registry demonstrate that single antiplatelet therapy (SAPT) after transcatheter aortic valve replacement (TAVR) is associated with a significantly lower incidence of six-month mortality and major bleeding risk compared to dual antiplatelet therapy (DAPT).

2 May 2025

Study shows safe outcomes for PCI performed in ambulatory surgery centers

The first study evaluating Medicare patients undergoing percutaneous coronary intervention (PCI) in ambulatory surgery centers (ASCs) demonstrated good safety outcomes, such as mortality and adverse event rates at 30 days, compared to outpatient hospital departments, but were less likely to use certain technologies.

2 May 2025

Study uncovers how a mobile genetic element hijacks human cells

Viruses are known to use the genetic machinery of the human cells they invade to make copies of themselves. As part of the process, viruses leave behind remnants throughout the genetic material (genomes) of humans.

2 May 2025

New studies link increased heart disease risk to tobacco and cannabis use

New clinical results from multiple studies show coronary heart disease death associated with tobacco use is anticipated to rise up to 40% in the next five years and people with cannabis use disorder are 50% more likely to experience cardiogenic shock, acute myocardial infarction, and arrhythmias.

2 May 2025

Lysosomal lipid peroxidation drives ferroptosis in cancer cells

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

2 May 2025

Learning from every patient: New radiotherapy technique aims to protect the heart during lung cancer treatment

A new study presented at ESTRO 2025 introduces the RAPID-RT study, which uses an innovative rapid-learning approach to evaluate the impact of treatment modifications in radiotherapy.

2 May 2025

Five major advances in anal and rectal cancer treatment with radiotherapy: A new era of organ-preserving options

Rectal cancer is a type of bowel cancer that develops in the last several centimeters of the large intestine, just before the anus.

2 May 2025

Study uses artificial intelligence to classify patient pain archetypes after knee replacement

A study using artificial intelligence to classify patient pain archetypes and identify risk for severe pain after knee replacement has earned a Best of Meeting award at the 50th Annual Meeting of the American Society of Regional Anesthesia and Pain Medicine.

2 May 2025

ZIP4 protein identified as driver of glioblastoma aggression

In a study published Wednesday in the Proceedings of the National Academy of Sciences (PNAS), University of Oklahoma researchers detail their discoveries about why the brain tumor glioblastoma is so aggressive.

2 May 2025

New drug technique targets gut inflammation with precision

A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments.

2 May 2025

Plasma activated medium shows promise against synovial sarcoma

Plasma-activated medium (PAM) shows tumor-fighting effects against the rare form of cancer known as synovial sarcoma, an Osaka Metropolitan University-led research team has found.

2 May 2025

Sapio Sciences introduces Biorepository Management solution in Sapio Release 25.4

Sapio Sciences, the science-aware™ lab informatics platform, today announced Sapio Release 25.4, introducing a new Biorepository Management solution, enhanced sample management capabilities, and platform-wide enhancements designed to streamline lab operations and support high-throughput research environments.

From Sapio Sciences 2 May 2025