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Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

A key hurdle in treating breast cancers is intratumoral heterogeneity, or the presence of multiple different cell populations within the same tumor that have distinct characteristics such as gene expression, metabolism and ability to divide, spread and grow.

29 Oct 2020

Researchers observe a rapid drop in average body temperature in tropical human population

In the nearly two centuries since German physician Carl Wunderlich established 98.6°F as the standard "normal" body temperature, it has been used by parents and doctors alike as the measure by which fevers -- and often the severity of illness -- have been assessed.

29 Oct 2020

Mouth may be primary route of SARS-CoV-2 infection and transmission

A new study published on the preprint server medRxiv in October 2020 shows that the virus also multiplies robustly in the oral cavity, indicating that saliva plays a role in viral transmission.

29 Oct 2020

Travel surges before lockdown undermine the SARS-CoV-2 containment effort

Recently, researchers from the Harvard T.H. Chan School of Public Health, Boston; the University of Illinois at Urbana Champaign; and the University of California, USA, assessed the impact of the announcement and implementation of restrictions such as lockdowns on mobility patterns of humans.

28 Oct 2020

REACT study shows 26% decline in SARS CoV-2 seroprevalence over 2-3 months

Their study titled, "Declining prevalence of antibody positivity to SARS-CoV-2: a community study of 365,000 adults," was released online as a pre-print on the medRxiv* server. This large study was funded by the Department of Health and Social Care in England.

28 Oct 2020

COVID-19 mortality rate declines significantly in Sweden

A new observational study by Swedish researchers shows a significant decline in death rates among hospitalized patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Their study titled, "Decline in mortality among hospitalized covid-19 patients in Sweden: a nationwide observational study," was released online as a preprint on the medRxiv* server.

28 Oct 2020

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

Tangles of misfolded tau proteins in the brain are closely associated with memory loss in patients with Alzheimer's disease. In order for this tau pathology to spread, the protein must interact with heparan sulfate, a sugar molecule found on the surface of neurons.

28 Oct 2020

High-sugar diet can damage the gut’s protective mucus layer, lead to worse colitis

Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut's protective mucus layer.

28 Oct 2020

Study finds no association between leisure activities and lower dementia risk

Studies have suggested that taking part in leisure activities such as playing cards or gardening may be associated with a lower risk of developing dementia.

28 Oct 2020

Antiseizure drug use during pregnancy linked with double the risk of having children with autism

Women with epilepsy who take the antiseizure drug valproic acid while pregnant are at more than double the risk of having children with autism spectrum disorder and nearly double the risk of having children with attention deficit hyperactivity disorder (ADHD), according to a study in the October 28, 2020, online issue of Neurology, the medical journal of the American Academy of Neurology.

28 Oct 2020

Researchers report outcomes of salvage low dose RT brachytherapy after EBRT for prostate cancer

Researchers involved in the phase II NRG Oncology RTOG 0526 trial studying low dose rate (LDR) prostate brachytherapy (BT) following local recurrence (LR) after external beam radiotherapy (EBRT) for patients with low-to-intermediate risk prostate cancer reported late Grade 3 gastrointestinal and genitourinary adverse events (AEs) occurring in 14% of trial participants.

28 Oct 2020

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

By leveraging nucleotide triphosphate analog-induced cell death, Chinese researchers unveiled genes that affect the import, export, and metabolism of pervasively used antiviral drugs in the treatment of coronavirus disease (COVID-19). This exciting study is currently available on the bioRxiv* preprint server.

28 Oct 2020

CAC scanning can help doctors decide which patients might benefit from aspirin therapy

An X-ray test commonly used to assess hardening of the arteries could help doctors decide whether the benefits of taking aspirin to prevent a first heart attack or stroke outweigh the risks of bleeding from its use, UT Southwestern research suggests.

28 Oct 2020

Studies suggest the need for a new home-time metric to judge hospital readmissions

Two new studies suggest Medicare's system of penalizing hospitals if too many patients are readmitted within 30 days should also look at whether the patients were well enough to remain in their home during that time.

28 Oct 2020

Study: Nearly 17% of recovered COVID-19 patients could still carry the virus

A new study in the American Journal of Preventive Medicine, published by Elsevier, presents new data that address important questions pertaining to the containment of the coronavirus pandemic: When should COVID-19 quarantine really end and which continuing symptoms may be more indicative of a positive test in recovered patients?

28 Oct 2020

Staff and families support use of COVID-19 mitigation measures in UK schools

Researchers in the UK have conducted a study showing that families and school staff support the use of coronavirus disease 2019 (COVID-19) mitigation measures in secondary schools as young people return to face-to-face education.

28 Oct 2020

Study finds persistence of racial disparities in treatment for common lung cancer

Lung cancer continues to be the most deadly solid cancer in the world, despite the fact that survival rates have been improving over the past decade.

28 Oct 2020

Study: COVID-19 vaccine nationalism could cost the global economy up to $1.2 trillion

Nationalistic behavior by governments may exclude some countries from gaining access to COVID-19 vaccines and cost the global economy up to $1.2 trillion a year in GDP, according to a new study from the not-for-profit research organization RAND Europe.

28 Oct 2020

Genomic analysis of early SARS-CoV-2 epidemic in the UK

By analyzing 50,887 SARS-CoV-2 genomes, the team has provided insights into the micro-epidemiological patterns underlying the features of one of the world's largest national COVID-19 epidemics.

28 Oct 2020

A systematic review and meta-analysis of stroke in COVID-19 patients

Fourteen out of every 1,000 COVID-19 patients admitted to hospital experience a stroke, a rate that is even higher in older patients and those with severe infection and pre-existing vascular conditions, according to a report published this week.

28 Oct 2020

Medical Research News

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

Researchers observe a rapid drop in average body temperature in tropical human population

Mouth may be primary route of SARS-CoV-2 infection and transmission

Travel surges before lockdown undermine the SARS-CoV-2 containment effort

REACT study shows 26% decline in SARS CoV-2 seroprevalence over 2-3 months

COVID-19 mortality rate declines significantly in Sweden

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

High-sugar diet can damage the gut’s protective mucus layer, lead to worse colitis

Study finds no association between leisure activities and lower dementia risk

Antiseizure drug use during pregnancy linked with double the risk of having children with autism

Researchers report outcomes of salvage low dose RT brachytherapy after EBRT for prostate cancer

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

CAC scanning can help doctors decide which patients might benefit from aspirin therapy

Studies suggest the need for a new home-time metric to judge hospital readmissions

Study: Nearly 17% of recovered COVID-19 patients could still carry the virus

Staff and families support use of COVID-19 mitigation measures in UK schools

Study finds persistence of racial disparities in treatment for common lung cancer

Study: COVID-19 vaccine nationalism could cost the global economy up to $1.2 trillion

Genomic analysis of early SARS-CoV-2 epidemic in the UK

A systematic review and meta-analysis of stroke in COVID-19 patients

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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