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Metastasis-free survival is strongly linked to overall survival of men treated for prostate cancer

An analysis of the phase III NRG Oncology clinical trial RTOG 9601 on men receiving salvage radiotherapy (SRT) following prostatectomy for recurrent prostate cancer indicated that, while biochemical failure (BF) was not a strong surrogate endpoint to determine overall survival (OS), metastasis-free survival (MFS) was in this patient population.

27 Oct 2020

Novel insights open up new avenues for treating autoimmune conditions

Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection. Regulatory T cells, or Tregs, are important players in striking this balance, acting as "brakes" on the immune response so it doesn't go overboard.

27 Oct 2020

New approach can prevent aggressive operation in certain rectal cancer patients

A nonsurgical treatment option for rectal cancer that preserves quality of life is safe for carefully selected patients, according to a new study comparing it with the standard operation.

27 Oct 2020

Study examines the long-term health effects of vaping, e-cigarettes on children

Adolescent use of e-cigarettes and vaping products is at epidemic proportions, yet the adverse health effects are understudied, with almost no data on younger patients.

27 Oct 2020

SARS-CoV-2 is mainly spread in households and household-like settings

Ten months into the coronavirus disease (COVID-19) pandemic, health experts have a good understanding of how the virus spreads. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads through respiratory droplets and aerosols and enters the body through the mouth, nose, and eyes.

27 Oct 2020

Scientists identify new target for developing novel drugs against several types of cancer

The Bcl-2 protein family comprises anti- and proapoptotic members, i.e. they protect the cell from death or favour it.

27 Oct 2020

Researchers develop low-cost, customizable, self-locking upper limb prosthesis

Upper limb forequarter amputations which involve the removal of the entire arm and scapula require highly customized prosthetic devices that are expensive but yet, usually underutilized due to their high maintenance and low comfort levels.

27 Oct 2020

Study analyzes link between clonal hematopoiesis and treatment-related blood cancer risk

In recent years, improvements in cancer therapy have led to a significant increase in cancer survivorship. Experts estimate that by 2022, the United States will have 18 million cancer survivors, but a subset of those survivors will have long-term health problems to be addressed.

27 Oct 2020

COVID-19 antibiotic risk factors

Now, a team of researchers at the University of Rochester Medical Center aimed to determine antibiotic prescribing rates and risk factors for antibiotic prescribing in hospitalized patients. They found that almost one-third of patients received more than one course of antibiotics.

27 Oct 2020

10-24-year-olds are as susceptible to COVID-19 as older adults

In an attempt to replicate the results of previous studies, a team of researchers performed statistical analyses on COVID-19 prevalence data from the U.S. to compare the number of cases in adolescents and youth to that in older adults. Their work is published on the preprint server medRxiv.

27 Oct 2020

New research on small non-coding RNAs and SARS-CoV-2

A recently published mini-review in the Frontiers in Microbiology on the altered expression of small non-coding RNAs during coronavirus-mediated infections.

26 Oct 2020

Phase 1 trial results of gorilla adenovirus vaccine for COVID-19

A recent study published on the preprint server bioRxiv* in October 2020 reports the development of a novel vaccine based on a simian adenoviral vector obtained from a group C gorilla isolate called GRAd32. This could help speed up vaccine development.

26 Oct 2020

Researchers generate a transcriptomic map of the COVID brain

COVID-19 is known to be associated with multiple changes in gene expression, but many of these are also seen in chronic brain conditions as well as in some abnormal mental conditions. A recent study published on the preprint server bioRxiv in October 2020 uncovers the molecular basis of this association.

26 Oct 2020

New peptide derivatives that target the SARS-CoV-2 spike protein

In a new study published in the journal Cellular and Molecular Bioengineering, researchers report peptide derivatives, or peptidomimetics, based on the circle residues involved in the interaction of the spike protein and ACE2.

26 Oct 2020

Transcriptomics identifies possible COVID-19 therapies

By using a diverse set of transcriptomic SARS-CoV-2 signatures, US researchers put to use their previously developed drug repositioning pipeline to pinpoint potential drug candidates for the treatment of coronavirus disease (COVID-19). The study is currently available on bioRxiv preprint server.

26 Oct 2020

Study suggests 5’UTR of SARS-CoV-2 might be of pangolin coronavirus origin

Findings from a new genomic sequencing study support the hypothesis that the pangolin was the intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that enabled transmission of the virus to humans.

26 Oct 2020

Nasal spray formulation of ivermectin for COVID-19 shows promise in pigs

Researchers in Argentina have conducted a pre-clinical study demonstrating the safety and pharmacokinetic performance of a new nasal spray formulation designed to suppress the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

26 Oct 2020

Joint Pathology Center selects Huron Digital Pathology’s image search engine to unlock vast knowledge contained in world’s largest human tissue repository

Huron Digital Pathology announced today that the Joint Pathology Center (JPC), the premier pathology reference center for the United States federal government and part of the US Defense Health Agency, has selected Huron’s artificial intelligence-enabled LagottoTM image search engine to index and search JPC’s growing digital image archive.

From Huron Technologies 26 Oct 2020

Research uncovers SARS-CoV-2 viral traits critical for the virus in human airways

A new study published on the preprint server bioRxiv* in October 2020 reports the discovery of important viral genomic features that are crucial to its replication in the human airway cells, and its enhancing mutations which increase the rate of replication and determine its target cells.

26 Oct 2020

Small molecules block SARS-CoV-2 spike-ACE2 attachment

The search includes immunological agents, enzyme inhibitors, and soluble competitive inhibitors. Now, a new study published on the preprint server bioRxiv in October 2020 provides preliminary evidence that small molecules can inhibit viral entry by inhibiting spike-ACE2 attachment.

26 Oct 2020