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Single-cell RNA sequencing sheds light on stroke-induced brain damage

Strokes lead to irreversible damage to the brain and are one of the most common causes of dependency or death.

1 Aug 2024

Highly inflammatory rheumatoid arthritis patients more susceptible to cognitive impairment

Researchers assessed cognitive function among rheumatoid arthritis patients with ongoing inflammatory activity.

1 Aug 2024

High-frequency eccentric resistance training decreases passive muscle stiffness

Resistance, or weight training, is widely recommended in sports and rehabilitation as an effective exercise to increase muscular strength and size. This form of exercise involves applying resistance to muscle contraction to build strength. However, some practitioners believe resistance training can increase passive muscle stiffness over time.

1 Aug 2024

New tool helps identify older adults at risk of falling

An aging society has posed a new global problem, the risk of falling. It is estimated that 1 in 3 adults over the age of 65 falls each year and the resulting injuries are becoming more prevalent.

1 Aug 2024

Study explores interplay between bone, adrenal glands, and aging

Figuring out how the tissues in our bones, adrenal glands, muscle and fat "talk" to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.

1 Aug 2024

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, even as people around the world live longer and the number of people with dementia is set to rise dramatically in all countries, according to the third Lancet Commission on dementia prevention, intervention, and care, which is being presented at the Alzheimer's Association International Conference (AAIC 2024).

1 Aug 2024

Novel anti-tuberculosis compound targets bacterial membrane protein

Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Duisburg-Essen (UDE) have together succeeded in identifying and synthesizing a group of molecules that can act against the cause of tuberculosis in a new way. In the scientific journal Cell Chemical Biology, they describe that the so-called callyaerins act against the infectious disease by employing a fundamentally different mechanism compared to antibiotic agents used to date.

1 Aug 2024

Researchers develop highly reactive RNA building blocks for enhanced chip production

An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical synthesis of these chips is now twice as fast and seven times more efficient. The results of the research were recently published in the prestigious journal Science Advances.

1 Aug 2024

New treatment option for endometrial cancer shows promise in phase II trial

The latest trial of a new antibody drug that delivers potent chemotherapy directly to cancer cells for patients with advanced or recurrent endometrial cancer moves ahead to be studied further in a phase III trial.

1 Aug 2024

Geographic analysis pinpoints areas for improved colorectal cancer screening in Hispanic/Latino populations

Cleveland Clinic-led research has identified geographic areas in the United States where strategic efforts to promote colorectal cancer screening could help reduce healthcare gaps affecting Hispanic/Latino communities.

1 Aug 2024

Masking policies prevalent in top cancer centers amid winter COVID wave

Nearly half of the nation's National Cancer Institute (NCI)-designated cancer centers required universal masking in key clinical areas during the winter 2023-2024 COVID-19 surge, according to a study by Tulane University researchers.

1 Aug 2024

Study reveals deepening mistrust in healthcare providers post-COVID

A cross-representative survey of adults in the United States showed decreasing levels of trust in physicians and hospitals during the COVID-19 pandemic - and the lower the trust, the less likely an individual was to get vaccinated against SARS-CoV-2 or influenza. The findings come from a survey study of more than 400,000 U.S. adults published in JAMA Network Open by a team co-led by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system.

1 Aug 2024

Study shows growing cancer burden in younger generations

A new large study led by researchers at the American Cancer Society (ACS) suggests incidence rates continued to rise in successively younger generations in 17 of the 34 cancer types, including breast, pancreatic, and gastric cancers.

1 Aug 2024

Scientists capture NMDAR protein's 'twist' motion, key to brain signaling

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These bindings control NMDAR's dance steps. When their routine is over, the NMDAR opens. This open ion channel generates electrical signals critical for cognitive functions like memory.

1 Aug 2024

Study: Many women unaware postmenopausal bleeding signals endometrial cancer

Despite the fact that endometrial cancer is the most common cancer of the female reproductive organs, a significant percentage of women do not know that postmenopausal bleeding is a key warning sign of the disease.

1 Aug 2024

Microbes play key role in carcinogenesis

At any given time, over 10 trillion microbes call our guts their home. From breaking down nutrients in our food to strengthening our immunity against pathogens, these microbes play an essential role in how we interact with the world. This includes – as shown in a new study by EMBL researchers and collaborators at the University of Split, Croatia – the way the body responds to carcinogens and develops cancer.

1 Aug 2024