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Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A new study preprint on the bioRxiv* server demonstrates the ability of a fatty acid synthase inhibitor to improve the survival of mice infected with murine hepatitis virus. In so doing, it adds to the sum of knowledge about the relationship of SARS-CoV-2 with cholesterol metabolism in the host cell.

24 Dec 2020

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

As the world struggles to contain the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for over 1.6 million deaths and 76 million infections globally, researchers are trying to pin down the determinants of lethality, of infectivity and of protection. Such data would help contain its spread and develop preventive and therapeutic antivirals and vaccines. A new preprint that appeared recently on the bioRxiv* server describes the high degree of protection afforded by antibodies that target the N-terminal domain (NTD) of the virus.

24 Dec 2020

Immunologic modeling of COVID-19 severity and chronicity

In a new study by researchers at Universidad de Costa Rica and other institutions, a bioinformatics approach is used to determine whether Chronic COVID-19 (CC) might have a distinct immunologic signature compared to the mild to moderate (MM) or the severe/critical COVID-19.

24 Dec 2020

Loss of taste and smell may be most reliable COVID-19 symptoms for digital surveillance

A team of researchers from various institutions in London, Israel, and the USA recently tested the existence of consistent links between COVID-19 symptoms and SARS-CoV-2 test status in 3 national surveillance platforms.

24 Dec 2020

Mental disorders highly prevalent during coronavirus pandemics

Researchers in the United States have conducted an analysis showing the high prevalence of mental disorders across populations impacted by coronavirus pandemics.

24 Dec 2020

Higher BMI linked to increased risk of SARS-CoV-2 infection

Researchers at the University of Miami Miller School of Medicine, USA, revealed that the spike-specific immunoglobulin G antibodies in obese people are negatively associated with body mass index (BMI) and serum levels of proinflammatory and metabolic markers of pulmonary inflammation.

24 Dec 2020

How has the COVID19 pandemic affected the well-being of pregnant women?

A new study by researchers at the Department of Women and Children’s Health at Uppsala University, Sweden, aimed to determine the effects of COVID-19 on pregnant women's mental health and well-being.

24 Dec 2020

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers found that cetylpyridinium chloride, found in most mouthwashes, lowers infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, likely by inhibiting viral fusion with target cells. With more tests to prove validity, mouthwashes could be a simple, cheap way of curbing transmission.

24 Dec 2020

Researchers review future directions of nanomedicine development

Announcing a new publication for BIO Integration journal. In this commentary the authors Phei Er Saw and Sangyong Jon from Sun Yat-Sen University, Guangzhou, China and the Korea Advanced Institute of Science and Technology, Daejeon, Korea, consider how the entry mechanism of nanoparticles into tumors determines the future direction of nanomedicine development.

24 Dec 2020

Study shows how human brains navigate physical space and keep track of others' location

For the first time, scientists have recorded how our brains navigate physical space and keep track of others' location. Researchers used a special backpack to wirelessly monitor the brain waves of epilepsy patients as each one walked around an empty room hunting for a hidden, two-foot spot.

24 Dec 2020

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer.

24 Dec 2020

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.

24 Dec 2020

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell.

24 Dec 2020

New tool may help monitor serotonin transmission with greater fidelity than current methods

Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings.

23 Dec 2020

Study reveals how our brains track where we and others go

As COVID cases rise, physically distancing yourself from other people has never been more important. Now a new UCLA study reveals how your brain navigates places and monitors someone else in the same location.

23 Dec 2020

Research demonstrates new mechanisms to control dental procedure spray emissions

Since the onset of COVID-19 the potential risk of dental procedure spray emissions for SARS-CoV-2 transmission has challenged care providers and policy makers alike.

23 Dec 2020

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

A team of scientists from the Centers for Disease Control and Prevention, United States, recently conducted a study to evaluate the effectiveness of serial testing and isolation of healthcare personnel in nursing homes in preventing the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Dec 2020

Public adherence to COVID-19 guidelines in Norway: a case study

To evaluate and understand the adherence to public health actions recommended by the government, a team in Norway undertook a study funded in part by the Norwegian Research Council’s Centres of Excellence Funding Scheme and by the project: A realtime analytical pipeline for preparedness, planning, and response during the COVID-19 pandemic in Norway.

23 Dec 2020

Genetic analysis reveals novel traits associated with COVID-19 severity

Researchers in the United States have conducted genetic correlation studies revealing novel traits associated with the development of severe coronavirus disease 2019 (COVID-19).

23 Dec 2020

Medical Science News

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

Immunologic modeling of COVID-19 severity and chronicity

Loss of taste and smell may be most reliable COVID-19 symptoms for digital surveillance

Mental disorders highly prevalent during coronavirus pandemics

Higher BMI linked to increased risk of SARS-CoV-2 infection

How has the COVID19 pandemic affected the well-being of pregnant women?

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers review future directions of nanomedicine development

Study shows how human brains navigate physical space and keep track of others' location

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

New tool may help monitor serotonin transmission with greater fidelity than current methods

Study reveals how our brains track where we and others go

Research demonstrates new mechanisms to control dental procedure spray emissions

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

Public adherence to COVID-19 guidelines in Norway: a case study

Genetic analysis reveals novel traits associated with COVID-19 severity

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

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