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Understanding the age gap in leukemia survival rates

Acute lymphoblastic leukemia (ALL) affects both children and adults, but children have better chances to be cured, with long-term survival rates over 85% compared to 50-75% in adults. Scientists at St. Jude Children's Research Hospital conducted a comprehensive study to understand the biological causes driving this difference. The work, published today in the Journal of Clinical Oncology, provides a blueprint for understanding B-cell acute lymphoblastic leukemia (B-ALL), the most common form of the disease.

7 Aug 2024

Surgery improves long-term outcomes for T-OPLL

Thoracic ossification of the posterior longitudinal ligament (TOPLL) is a rare condition associated with ectopic bone formation in the thoracic spine.

7 Aug 2024

Study highlights the need for language services in cancer trials

Underrepresentation of racial and ethnic minority populations in cancer clinical trials persists partly because translation and interpretation services and resources are unavailable or inadequate in the United States, according to a Children's Oncology Group (COG) study led by Columbia University School of Nursing. The updated study was published online in the Journal of the National Cancer Institute Cancer Spectrum on July 25, 2024, and will appear in the August 2024 journal issue.

7 Aug 2024

Artificial stone worktops pose serious health hazard

It may now be time to ban artificial stone - a firm favorite for kitchen worktops in the UK - to ward off the incurable lung disease caused by its manufacturing and fitting, say a team of doctors in the journal Thorax after treating the first 8 cases of artificial stone silicosis reported in the UK.

7 Aug 2024

Study uncovers roles of certain brain cells in Alzheimer's plaque formation

A study in Nature Neuroscience found that both neurons and oligodendrocytes contribute to amyloid-β plaque burden in Alzheimer's disease, highlighting new therapeutic targets.

7 Aug 2024

Online communities offer support but come with many risks, says new study

A review in Communications Psychology explores the motivations and diverse impacts of joining digital communities, highlighting both risks and opportunities for support and prevention.

6 Aug 2024

Yogurt with probiotics and honey boosts gut bacteria but no digestive or cognitive benefits

A study in The Journal of Nutrition found that yogurt with B. animalis and honey increases probiotic levels but doesn't affect digestion, cognition, or mood.

6 Aug 2024

Study uncovers how TREM2 R47H mutation affects Alzheimer's plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

6 Aug 2024

Study reveals distinct genetic risk factors for influenza and COVID-19

A recent study in Nature Genetics reports that genetic risk factors for influenza and COVID-19 are distinct, highlighting their unique genetic architectures.

6 Aug 2024

Innovative nasal spray and vaccine for respiratory virus protection

A team of researchers, led by the University of Houston, has discovered two new ways of preventing and treating respiratory viruses.

6 Aug 2024

Analyzing the impact of heart disease treatments on patients with CHIP

Nicholas A. Marston, MD, MPH, of the TIMI Study Group and Carl J. and Ruth Shapiro Cardiovascular Center at Brigham and Women's Hospital, is the corresponding author of a paper published in Nature Medicine, "Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials."

6 Aug 2024

Accelerated neuronal development linked to intellectual disabilities and autism

The mechanisms underlying intellectual disabilities or autism remain largely unknown. Researchers in the labs of Prof. Pierre Vanderhaeghen and Prof. Vincent Bonin at the VIB-KU Leuven Center for Brain & Disease Research and NERF have discovered that mutations in a gene called SYNGAP1 disrupt the prolonged development of human neurons, which is thought to be essential for normal cognitive function.

6 Aug 2024

Mental exertion and unpleasant feelings

If somebody complains that it hurts to think, they may be onto something, as mental exertion appears to be associated with unpleasant feelings in many situations, according to research published by the American Psychological Association.

6 Aug 2024

Potential liver risks from popular herbal supplements revealed in new study

A study in JAMA Network Open reveals that 5% of U.S. adults consume six potentially hepatotoxic botanicals, highlighting a significant need for increased regulatory oversight.

6 Aug 2024

Omega-3 fatty acids show potential in protecting brain health in older adults

Researchers assess the role of ω-3 polyunsaturated fatty acids (PUFAs) in reducing white matter lesion accumulation and neuronal integrity degeneration.

6 Aug 2024

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

Grab a drink with friends at happy hour and you're likely to feel chatty, friendly and upbeat. But grab a drink alone and you may experience feelings of depression.

6 Aug 2024

Enhancing nitrofurantoin solubility and bioavailability through solid dispersion formulation

Announcing a new article publication for BIO Integration journal. Nitrofurantoin is a BCS II drug with a low solubility and dissolution rate.

6 Aug 2024

Brain chemical orexin plays key role in choosing exercise over treats

Should I go and exercise, or would I rather go to the café and enjoy a delectable strawberry milkshake? Until now, what exactly happens in our brain when we make this decision has been a mystery to science, but researchers at ETH Zurich have found the solution.

6 Aug 2024

Breakthrough therapy enhances longevity and vitality in aging mice

Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, University of Connecticut researchers have demonstrated a treatment that could lengthen life - and vigor - up to the very end.

6 Aug 2024