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AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

8 Jan 2014

Fetal exposure to Bisphenol A can increase risk for prostate cancer later in life

Fetal exposure to a commonly used plasticizer found in products such as water bottles, soup can liners and paper receipts can increase the risk for prostate cancer later in life, according to a study from the University of Illinois at Chicago published Jan. 7 online in the journal Endocrinology.

8 Jan 2014

Erythropoietin may promote cancer cell proliferation and survival

In recent years, non-hematopoietic effects of erythropoietin (EPO), via its binding to the EPO receptor in non-hematopoietic tissues, including cancerous tissues, has been reported by many different laboratories worldwide.

7 Jan 2014

Study sheds light on the biological underpinnings of obesity

A new neuroscience study sheds light on the biological underpinnings of obesity. The in vivo study, published in the January 8 issue of the Journal of Neuroscience, reveals how a protein in the brain helps regulate food intake and body weight. The findings reveal a potential new avenue for the treatment of obesity and may help explain why medications that are prescribed for epilepsy and other conditions that interfere with this protein, such as gabapentin and pregabalin, can cause weight gain.

7 Jan 2014

Study finds link between common beliefs and e-cigarette use among young adults

Despite years of anti-smoking education and legislation, tobacco use still remains an important public health issue in the United States. In 2010, 25.2% of all adults and 35.6% of young adults reported current tobacco use.

7 Jan 2014

Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

Although brain growth slows as individuals age, some regions of the brain continue to develop for longer than others, creating new connections and remodeling existing circuitry.

7 Jan 2014

Memorial Sloan-Kettering to use Sutro's cell-free protein synthesis technology to produce bispecific antibodies

Sutro Biopharma, a biopharmaceutical company developing a new generation of protein therapeutics, including next-generation antibody drug conjugates and bispecific antibodies, today announced that it has entered into a collaboration agreement with Memorial Sloan-Kettering Cancer Center to use Sutro's proprietary cell-free protein synthesis technology to produce bispecific antibodies that were discovered by Memorial Sloan-Kettering for the treatment of neuroblastoma in children.

7 Jan 2014

Elderly people with high serum vitamin E levels less likely to suffer from memory disorders

Elderly people with high serum vitamin E levels are less likely to suffer from memory disorders than their peers with lower levels, according to a study published recently in Experimental Gerontology.

7 Jan 2014

Crowdsourcing fungal metabolites with antitumor activity: an interview with Dr. Robert H. Cichewicz, University of Oklahoma

Fungi have played a large role in the development of many important drugs that are in wide use today. The most well-known of these are the penicillins.

7 Jan 2014

Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Horizon Discovery and AstraZeneca have entered into a research, collaboration and license agreement to explore a range of oncology-relevant genotypes with the aim of identifying and validating a number of novel drug targets. This deal is the second collaboration between AstraZeneca and Horizon, and follows the announcement in April 2013 of an oncology discovery program to explore Horizon's first-in-class kinase target program, HD-001.

7 Jan 2014

Mannotriose regulates learning and memory signal transduction in hippocampus

The main component of the Chinese herb Rehmannia, mannotriose, can improve learning and memory. Dr. Lina Zhang and colleagues from Shanghai University of Traditional Chinese Medicine in China used 1 - 10 mol/L mannotriose to treat primary hippocampal neurons insulted with 1 - 10 mol/L corticosterone.

7 Jan 2014

Study quantifies photoactivation efficiency of fluorescent proteins

To know how many proteins assemble together at the nanoscale is fundamental for understanding protein function. Sometimes, proteins must be in an "oligomeric" state to be functional, although "oligomerization" of certain proteins can also lead to diseases. The ability to determine protein stoichiometry and monitor changes in the balance between monomeric, dimeric and multi-meric proteins can allow scientists to see the differences between a properly functioning cell and a diseased cell. Therefore, there is a great interest in being able to count proteins and determine their stoichiometry.

7 Jan 2014

Researchers work on alternative therapy to boost immune system of patients with lung cancer

Research from the National Institute of Respiratory Diseases informs that besides smoking, there are other factors associated to the development of lung cancer such as the smoke from burning lumber and coal, as well as pollutant particles.

7 Jan 2014

Mutations in small proteins that help convey electrical signals may influence nerve health

Mutations in small proteins that help convey electrical signals throughout the body may have a surprisingly large effect on health, according to results of a new Johns Hopkins study study published in Proceedings of the National Academy of Sciences in December using spider, scorpion and sea anemone venom.

7 Jan 2014

MD Anderson, Pfizer to advance development of immune-based treatment for cancer

The University of Texas MD Anderson Cancer Center and Pfizer will collaborate in the development of immune-based approaches to cancer treatment, the first such agreement made through MD Anderson's Moon Shots Program immunotherapy platform.

6 Jan 2014

Protein may be major culprit when breast cancer metastasizes to the brain

A cancer-research team at the University of Wisconsin-Madison has identified a protein that may be a major culprit when breast cancer metastasizes to the brain.

6 Jan 2014

Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore (NUS) have discovered a biomarker, called adenosine deaminase acting on RNA-1 (ADAR1), which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

New approach aims to prevent brain cancer recurrence by attacking tumors at the source

Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery identified immune system targets on cancer stem cells - cells from which malignant brain tumors are believed to originate and regenerate - and created an experimental vaccine to attack them.

6 Jan 2014

Researchers discover novel compounds that are hundreds of times more mutagenic

Researchers at Oregon State University have discovered novel compounds produced by certain types of chemical reactions - such as those found in vehicle exhaust or grilling meat - that are hundreds of times more mutagenic than their parent compounds which are known carcinogens.

6 Jan 2014

LA BioMed receives grant to study role of serum Vitamin A in people with multiple sclerosis

Some 2.5 million people around the world have multiple sclerosis (MS), a potentially debilitating disease in which the body's immune system destroys the protective sheath (myelin) that covers nerves.

6 Jan 2014

Medical Science News

AP-1 proteins modulate fat accumulation in liver, say researchers

Fetal exposure to Bisphenol A can increase risk for prostate cancer later in life

Erythropoietin may promote cancer cell proliferation and survival

Study sheds light on the biological underpinnings of obesity

Study finds link between common beliefs and e-cigarette use among young adults

Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

Memorial Sloan-Kettering to use Sutro's cell-free protein synthesis technology to produce bispecific antibodies

Elderly people with high serum vitamin E levels less likely to suffer from memory disorders

Crowdsourcing fungal metabolites with antitumor activity: an interview with Dr. Robert H. Cichewicz, University of Oklahoma

Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Mannotriose regulates learning and memory signal transduction in hippocampus

Study quantifies photoactivation efficiency of fluorescent proteins

Researchers work on alternative therapy to boost immune system of patients with lung cancer

Mutations in small proteins that help convey electrical signals may influence nerve health

MD Anderson, Pfizer to advance development of immune-based treatment for cancer

Protein may be major culprit when breast cancer metastasizes to the brain

Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

New approach aims to prevent brain cancer recurrence by attacking tumors at the source

Researchers discover novel compounds that are hundreds of times more mutagenic

LA BioMed receives grant to study role of serum Vitamin A in people with multiple sclerosis

Fluidics in Modern Healthcare & Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

How does norepinephrine influence anxiety-related behaviours?

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